4LT5
| Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA | 分子名称: | 1,2-ETHANEDIOL, DNA, MANGANESE (II) ION, ... | 著者 | Hashimoto, H, Pais, J.E, Zhang, X, Saleh, L, Fu, Z.Q, Dai, N, Correa, I.R, Roberts, R.J, Zheng, Y, Cheng, X. | 登録日 | 2013-07-23 | 公開日 | 2013-12-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.893 Å) | 主引用文献 | Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA. Nature, 506, 2014
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5EGB
| Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence II | 分子名称: | DNA (5'-D(*AP*CP*CP*AP*CP*GP*TP*GP*GP*CP*TP*AP*GP*GP*GP*AP*GP*GP*CP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*GP*CP*CP*TP*CP*CP*CP*TP*AP*GP*CP*CP*AP*CP*GP*TP*GP*G)-3'), Histone-lysine N-methyltransferase PRDM9, ... | 著者 | Patel, A, Horton, J.R, Wilson, G.G, Zhang, X, Cheng, X. | 登録日 | 2015-10-26 | 公開日 | 2016-02-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.977 Å) | 主引用文献 | Structural basis for human PRDM9 action at recombination hot spots. Genes Dev., 30, 2016
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4M9E
| Structure of Klf4 zinc finger DNA binding domain in complex with methylated DNA | 分子名称: | ACETATE ION, DNA (5'-D(*GP*AP*GP*GP*(5CM)P*GP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*(5CM)P*GP*CP*CP*TP*C)-3'), ... | 著者 | Liu, Y, Olanrewaju, Y.O, Blumenthal, R.M, Zhang, X, Cheng, X. | 登録日 | 2013-08-14 | 公開日 | 2014-02-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | 主引用文献 | Structural basis for Klf4 recognition of methylated DNA. Nucleic Acids Res., 42, 2014
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6O0S
| Crystal structure of the tandem SAM domains from human SARM1 | 分子名称: | Sterile alpha and TIR motif-containing protein 1 | 著者 | Horsefield, S, Burdett, H, Zhang, X, Manik, M.K, Shi, Y, Chen, J, Tiancong, Q, Gilley, J, Lai, J, Gu, W, Rank, M, Deerain, N, Casey, L, Ericsson, D.J, Foley, G, Hughes, R.O, Bosanac, T, von Itzstein, M, Rathjen, J.P, Nanson, J.D, Boden, M, Dry, I.B, Williams, S.J, Staskawicz, B.J, Coleman, M.P, Ve, T, Dodds, P.N, Kobe, B. | 登録日 | 2019-02-17 | 公開日 | 2019-09-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | NAD+cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365, 2019
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6O0T
| Crystal structure of selenomethionine labelled tandem SAM domains (L446M:L505M:L523M mutant) from human SARM1 | 分子名称: | Sterile alpha and TIR motif-containing protein 1 | 著者 | Horsefield, S, Burdett, H, Zhang, X, Manik, M.K, Shi, Y, Chen, J, Tiancong, Q, Gilley, J, Lai, J, Gu, W, Rank, M, Deerain, N, Casey, L, Ericsson, D.J, Foley, G, Hughes, R.O, Bosanac, T, von Itzstein, M, Rathjen, J.P, Nanson, J.D, Boden, M, Dry, I.B, Williams, S.J, Staskawicz, B.J, Coleman, M.P, Ve, T, Dodds, P.N, Kobe, B. | 登録日 | 2019-02-17 | 公開日 | 2019-09-04 | 最終更新日 | 2020-01-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | NAD+cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365, 2019
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7ZL9
| Crystal structure of human GPCR Niacin receptor (HCA2) | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, DI(HYDROXYETHYL)ETHER, Hydroxycarboxylic acid receptor 2,Soluble cytochrome b562, ... | 著者 | Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, Han, G.W, FiBerto, J.F, Wu, L.J, Tong, J.H, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J. | 登録日 | 2022-04-14 | 公開日 | 2023-04-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural insights into the human niacin receptor HCA2-G i signalling complex. Nat Commun, 14, 2023
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7ZLY
| Crystal structure of human GPCR Niacin receptor (HCA2) expressed from Spodoptera frugiperda | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Hydroxycarboxylic acid receptor 2,Soluble cytochrome b562, OLEIC ACID | 著者 | Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, FiBerto, J.F, Wu, L.J, Tong, J.H, Han, G.W, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J. | 登録日 | 2022-04-17 | 公開日 | 2023-04-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural insights into the human niacin receptor HCA2-G i signalling complex. Nat Commun, 14, 2023
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3EA1
| Crystal Structure of the Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis | 分子名称: | 1-phosphatidylinositol phosphodiesterase, ZINC ION | 著者 | Shi, X, Shao, C, Zhang, X, Zambonelli, C, Redfied, A.G, Head, J.F, Seaton, B.A, Roberts, M.F. | 登録日 | 2008-08-24 | 公開日 | 2009-04-14 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Modulation of bacillus thuringiensis phosphatidylinositol-specific phospholipase C activity by mutations in the putative dimerization interface. J.Biol.Chem., 284, 2009
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4MGG
| Crystal structure of an enolase (mandelate racemase subgroup) from labrenzia aggregata iam 12614 (target nysgrc-012903) with bound mg, space group p212121 | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Muconate lactonizing enzyme, ... | 著者 | Vetting, M.W, Zhang, X, Wasserman, S.R, Morisco, L.L, Sojitra, S, Bonanno, J.B, Gerlt, J.A, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2013-08-28 | 公開日 | 2013-10-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of an enolase (mandelate racemase subgroup) from labrenzia aggregata iam 12614 (target nysgrc-012903) with bound mg, space group p212121 To be Published
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8YDC
| Crystal structure of a hammerhead ribozyme with pseudoknot | 分子名称: | DNA/RNA (5'-R(*AP*CP*AP*UP*GP*UP*CP*U)-D(P*C)-R(P*UP*GP*GP*GP*A)-3'), GUANOSINE-5'-TRIPHOSPHATE, ribozyme strand | 著者 | Liu, Y, Zhan, X. | 登録日 | 2024-02-20 | 公開日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | The structure and catalytic mechanism of a pseudoknot-containing hammerhead ribozyme. Nat Commun, 15, 2024
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4M8M
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2W5R
| Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS. | 分子名称: | (2R)-2,3-dihydroxypropyl phosphate, ACETATE ION, MANGANESE (II) ION, ... | 著者 | Lu, D, Wormann, M.E, Zhang, X, Schneewind, O, Grundling, A, Freemont, P.S. | 登録日 | 2008-12-11 | 公開日 | 2009-02-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure-Based Mechanism of Lipoteichoic Acid Synthesis by Staphylococcus Aureus Ltas. Proc.Natl.Acad.Sci.USA, 106, 2009
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2W5S
| Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS. | 分子名称: | (2R)-2,3-dihydroxypropyl phosphate, ACETATE ION, MANGANESE (II) ION, ... | 著者 | Lu, D, Wormann, M.E, Zhang, X, Schneewind, O, Grundling, A, Freemont, P.S. | 登録日 | 2008-12-11 | 公開日 | 2009-02-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Based Mechanism of Lipoteichoic Acid Synthesis by Staphylococcus Aureus Ltas. Proc.Natl.Acad.Sci.USA, 106, 2009
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8IAB
| The Arabidopsis CLCa transporter bound with chloride, ATP and PIP2 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Chloride channel protein CLC-a, ... | 著者 | Yang, Z, Zhang, X, Zhang, P. | 登録日 | 2023-02-08 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids. Nat Commun, 14, 2023
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8IAD
| The Arabidopsis CLCa transporter bound with nitrate, ATP and PIP2 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Chloride channel protein CLC-a, MAGNESIUM ION, ... | 著者 | Yang, Z, Zhang, X, Zhang, P. | 登録日 | 2023-02-08 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids. Nat Commun, 14, 2023
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7BW7
| Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin. | 分子名称: | Insulin fusion, Insulin receptor | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | 登録日 | 2020-04-13 | 公開日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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7BW8
| Cryo-EM Structure for the Insulin Binding Region in the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin | 分子名称: | Insulin fusion, Insulin receptor | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | 登録日 | 2020-04-14 | 公開日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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4DFF
| The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia | 分子名称: | 8,9-dimethoxy-1-(1,3-thiazol-5-yl)-5,6-dihydroimidazo[5,1-a]isoquinoline, MAGNESIUM ION, ZINC ION, ... | 著者 | Ho, G.D, Seganish, W.M, Bercovici, A, Tulshian, D, Greenlee, W.J, Van Rijn, R, Hruza, A, Xiao, L, Rindgen, D, Mullins, D, Guzzi, M, Zhang, X, Bleichardt, C, Hodgson, R. | 登録日 | 2012-01-23 | 公開日 | 2012-03-14 | 最終更新日 | 2012-04-04 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg.Med.Chem.Lett., 22, 2012
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4DHI
| Structure of C. elegans OTUB1 bound to human UBC13 | 分子名称: | Ubiquitin thioesterase otubain-like, Ubiquitin-conjugating enzyme E2 N | 著者 | Wiener, R, Zhang, X, Wang, T, Wolberger, C. | 登録日 | 2012-01-27 | 公開日 | 2012-02-22 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature, 483, 2012
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8WCJ
| Crystal structure of GB3 penta mutation L5V/K10H/T16S/K19E/Y33I | 分子名称: | Immunoglobulin G-binding protein G | 著者 | Qin, M.M, Chen, X.X, Zhang, X.Y, Song, X.F, Yao, L.S. | 登録日 | 2023-09-12 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Protein Allostery Study in Cells Using NMR Spectroscopy. Anal.Chem., 96, 2024
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8XI4
| Structure of Eastern Equine Encephalitis VLP in complex with the receptor VLDLR LA1-2 | 分子名称: | CALCIUM ION, Capsid protein, Spike glycoprotein E1, ... | 著者 | Cao, D, Ma, B, Cao, Z, Xu, X, Zhang, X, Xiang, Y. | 登録日 | 2023-12-19 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes. Nat Commun, 15, 2024
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8XI5
| Structure of Eastern Equine Encephalitis VLP in complex with the receptor VLDLR LA3-5 | 分子名称: | CALCIUM ION, Capsid protein, Spike glycoprotein E1, ... | 著者 | Cao, D, Ma, B, Cao, Z, Xu, X, Zhang, X, Xiang, Y. | 登録日 | 2023-12-19 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes. Nat Commun, 15, 2024
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8WQL
| In situ PBS-PSII supercomplex from cyanobacterial Spirulina platensis | 分子名称: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | 著者 | You, X, Zhang, X, Xiao, Y.N, Sun, S, Sui, S.F. | 登録日 | 2023-10-11 | 公開日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of in situ PBS-PSII supercomplex at 3.5 Angstroms resolution. To Be Published
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8IHP
| Structure of Semliki Forest virus VLP in complex with the receptor VLDLR-LA3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Capsid protein, ... | 著者 | Cao, D, Ma, B, Cao, Z, Zhang, X, Xiang, Y. | 登録日 | 2023-02-23 | 公開日 | 2023-04-12 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of Semliki Forest virus in complex with its receptor VLDLR. Cell, 186, 2023
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5XPD
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