8IRO
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![BU of 8iro by Molmil](/molmil-images/mine/8iro) | trans-Zeatin bound state of Arabidopsis AZG1 at pH7.4 | Descriptor: | (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Adenine/guanine permease AZG1 | Authors: | Xu, L, Guo, J. | Deposit date: | 2023-03-19 | Release date: | 2024-01-17 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1. Nat.Plants, 10, 2024
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5F6T
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![BU of 5f6t by Molmil](/molmil-images/mine/5f6t) | Structure of calexcitin-Gd3+ complex. | Descriptor: | CALCIUM ION, Calexcitin, GADOLINIUM ATOM | Authors: | Chataigner, L, Guo, J, Erskine, P.T, Coker, A.R, Wood, S.P, Cooper, J.B. | Deposit date: | 2015-12-06 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.201 Å) | Cite: | Binding of Gd(3+) to the neuronal signalling protein calexcitin identifies an exchangeable Ca(2+)-binding site. Acta Crystallogr.,Sect.F, 72, 2016
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8JM9
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![BU of 8jm9 by Molmil](/molmil-images/mine/8jm9) | |
8JMI
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![BU of 8jmi by Molmil](/molmil-images/mine/8jmi) | |
8JMA
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![BU of 8jma by Molmil](/molmil-images/mine/8jma) | |
8JME
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![BU of 8jme by Molmil](/molmil-images/mine/8jme) | |
8JMH
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![BU of 8jmh by Molmil](/molmil-images/mine/8jmh) | |
5GOV
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![BU of 5gov by Molmil](/molmil-images/mine/5gov) | Crystal Structure of MCR-1, a phosphoethanolamine transferase, extracellular domain | Descriptor: | Probable phosphatidylethanolamine transferase Mcr-1, ZINC ION | Authors: | Hu, M, Guo, J, Chen, S, Hao, Q. | Deposit date: | 2016-07-29 | Release date: | 2016-12-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Crystal Structure of Escherichia coli originated MCR-1, a phosphoethanolamine transferase for Colistin Resistance. Sci Rep, 6, 2016
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8I5M
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![BU of 8i5m by Molmil](/molmil-images/mine/8i5m) | Rat Kir4.1 in complex with PIP2 | Descriptor: | ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Zhao, C, Guo, J. | Deposit date: | 2023-01-26 | Release date: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Pharmacological inhibition of astrocytic Kir4.1 channel evokes rapid-onset antidepressant responses To Be Published
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8I5N
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![BU of 8i5n by Molmil](/molmil-images/mine/8i5n) | Rat Kir4.1 in complex with PIP2 and Lys05 | Descriptor: | ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Zhao, C, Guo, J. | Deposit date: | 2023-01-26 | Release date: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Pharmacological inhibition of astrocytic Kir4.1 channel evokes rapid-onset antidepressant responses To Be Published
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6KKT
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![BU of 6kkt by Molmil](/molmil-images/mine/6kkt) | human KCC1 structure determined in KCl and lipid nanodisc | Descriptor: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Liu, S, Chang, S, Ye, S, Bai, X, Guo, J. | Deposit date: | 2019-07-27 | Release date: | 2019-10-23 | Last modified: | 2020-08-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science, 366, 2019
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6KKR
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![BU of 6kkr by Molmil](/molmil-images/mine/6kkr) | human KCC1 structure determined in KCl and detergent GDN | Descriptor: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Liu, S, Chang, S, Ye, S, Bai, X, Guo, J. | Deposit date: | 2019-07-27 | Release date: | 2019-10-23 | Last modified: | 2020-08-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science, 366, 2019
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6KKU
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![BU of 6kku by Molmil](/molmil-images/mine/6kku) | human KCC1 structure determined in NaCl and GDN | Descriptor: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Liu, S, Chang, S, Ye, S, Bai, X, Guo, J. | Deposit date: | 2019-07-27 | Release date: | 2019-10-23 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science, 366, 2019
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5WPQ
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![BU of 5wpq by Molmil](/molmil-images/mine/5wpq) | Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed I conformation at 3.64 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | Authors: | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | Deposit date: | 2017-08-07 | Release date: | 2017-10-18 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017
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5WPV
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![BU of 5wpv by Molmil](/molmil-images/mine/5wpv) | Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs at 3.59 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | Authors: | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | Deposit date: | 2017-08-07 | Release date: | 2017-10-18 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017
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5XM5
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![BU of 5xm5 by Molmil](/molmil-images/mine/5xm5) | |
7F6G
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![BU of 7f6g by Molmil](/molmil-images/mine/7f6g) | Cryo-EM structure of human angiotensin receptor AT1R in complex Gq proteins and Sar1-AngII | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin receptor AT1R, CHOLESTEROL, ... | Authors: | Zhang, D, Xu, L, Zhan, Y, Guo, J, Zhang, H. | Deposit date: | 2021-06-25 | Release date: | 2023-03-29 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists. Embo J., 42, 2023
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5ZAZ
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7F4H
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![BU of 7f4h by Molmil](/molmil-images/mine/7f4h) | Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein, Nb35 and scFv16 | Descriptor: | Afamelanotide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. | Deposit date: | 2021-06-18 | Release date: | 2021-09-08 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
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7F4I
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![BU of 7f4i by Molmil](/molmil-images/mine/7f4i) | Cryo-EM structure of SHU9119-bound melanocortin-1 receptor in complex with Gs protein and Nb35 | Descriptor: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. | Deposit date: | 2021-06-18 | Release date: | 2021-09-08 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
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7F4D
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![BU of 7f4d by Molmil](/molmil-images/mine/7f4d) | Cryo-EM structure of alpha-MSH-bound melanocortin-1 receptor in complex with Gs protein and Nb35 | Descriptor: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. | Deposit date: | 2021-06-18 | Release date: | 2021-09-08 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
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7F4F
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![BU of 7f4f by Molmil](/molmil-images/mine/7f4f) | Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein and scFv16 | Descriptor: | Afamelanotide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. | Deposit date: | 2021-06-18 | Release date: | 2021-09-08 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
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7FHN
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![BU of 7fhn by Molmil](/molmil-images/mine/7fhn) | Structure of AtTPC1 D240A/D454A/E528A mutant with 1 mM Ca2+ | Descriptor: | CALCIUM ION, Two pore calcium channel protein 1,GFP | Authors: | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | Deposit date: | 2021-07-29 | Release date: | 2021-12-01 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7FHO
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![BU of 7fho by Molmil](/molmil-images/mine/7fho) | Structure of AtTPC1 D240A/D454A/E528A mutant with 50 mM Ca2+ | Descriptor: | CALCIUM ION, Two pore calcium channel protein 1,GFP | Authors: | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | Deposit date: | 2021-07-29 | Release date: | 2021-12-01 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7FHL
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![BU of 7fhl by Molmil](/molmil-images/mine/7fhl) | Structure of AtTPC1 with 50 mM Ca2+ | Descriptor: | AtTPC1-Cter, CALCIUM ION, Two pore calcium channel protein 1,GFP | Authors: | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | Deposit date: | 2021-07-29 | Release date: | 2021-12-01 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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