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PDB: 39 件
3I9O
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Crystal structure of ADP ribosyl cyclase complexed with ribo-2'F-ADP ribose
分子名称: ADP-ribosyl cyclase, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
著者Graeff, R, Liu, Q, Kriksunov, I.A, Kotaka, M, Oppenheimer, N, Hao, Q, Lee, H.C.
登録日2009-07-12
公開日2009-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38
J.Biol.Chem., 284, 2009
3F6Y
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Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium
分子名称: ADP-ribosyl cyclase 1, CALCIUM ION
著者Liu, Q, Graeff, R, Kriksunov, I.A, Lam, C.M.C, Lee, H.C, Hao, Q.
登録日2008-11-07
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium
Biochemistry, 47, 2008
3ZWM
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Crystal structure of ADP ribosyl cyclase complexed with substrate NAD and product cADPR
分子名称: ADP-RIBOSYL CYLCASE, CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
登録日2011-08-02
公開日2011-11-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWO
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Crystal structure of ADP ribosyl cyclase complexed with reaction intermediate
分子名称: 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYD ROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2- YL]PYRIDINIUM, ADP-RIBOSYL CYCLASE, GUANOSINE DIPHOSPHATE RIBOSE
著者Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
登録日2011-08-02
公開日2011-11-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWY
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Crystal structure of ADP-ribosyl cyclase complexed with 8-bromo-ADP- ribose and cyclic 8-bromo-cyclic-ADP-ribose
分子名称: (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide, ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4S)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
著者Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
登録日2011-08-03
公開日2012-08-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
To be Published
3ZWW
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Crystal structure of ADP-ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.3 angstrom
分子名称: ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
著者Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
登録日2011-08-03
公開日2011-11-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWX
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Crystal structure of ADP-ribosyl cyclase complexed with 8-bromo-ADP- ribose
分子名称: ADP-RIBOSYL CYCLASE, CHLORIDE ION, [(2R,3S,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4S)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
著者Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
登録日2011-08-03
公開日2012-08-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
To be Published
1YH3
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Crystal structure of human CD38 extracellular domain
分子名称: ADP-ribosyl cyclase 1
著者Liu, Q, Kriksunov, I.A, Graeff, R, Munshi, C, Lee, H.C, Hao, Q.
登録日2005-01-06
公開日2005-09-27
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Crystal structure of human CD38 extracellular domain.
Structure, 13, 2005
2PGJ
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Catalysis associated conformational changes revealed by human cd38 complexed with a non-hydrolyzable substrate analog
分子名称: ADP-ribosyl cyclase 1, N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE
著者Liu, Q, Kriksunov, I.A, Moreau, C, Graeff, R, Potter, B.V.L, Lee, H.C, Hao, Q.
登録日2007-04-09
公開日2007-04-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Catalysis-associated Conformational Changes Revealed by Human CD38 Complexed with a Non-hydrolyzable Substrate Analog
J.Biol.Chem., 282, 2007
2PGL
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Catalysis associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog
分子名称: ADP-ribosyl cyclase 1, N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE
著者Liu, Q, Kriksunov, I.A, Moreau, C, Graeff, R, Potter, B.V.L, Lee, H.C, Hao, Q.
登録日2007-04-09
公開日2007-04-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Catalysis-associated Conformational Changes Revealed by Human CD38 Complexed with a Non-hydrolyzable Substrate Analog
J.Biol.Chem., 282, 2007
3U4H
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CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template
分子名称: 8-Amino-N1-Cyclic Inosine 5'-Diphosphoribose, ADP-ribosyl cyclase 1
著者Liu, Q, Hao, Q, Lee, H.C, Graeff, R.
登録日2011-10-08
公開日2012-10-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.878 Å)
主引用文献CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template
Plos One, 8, 2013
3U4I
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CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template
分子名称: ADP-ribosyl cyclase 1, Cyclic adenosine 5'-diphosphocarbocyclic ribose
著者Liu, Q, Hao, Q, Lee, H.C, Graeff, R.
登録日2011-10-08
公開日2012-10-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.118 Å)
主引用文献CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template
Plos One, 8, 2013
3ZWN
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Crystal structure of Aplysia cyclase complexed with substrate NGD and product cGDPR
分子名称: 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYD ROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2- YL]PYRIDINIUM, ADP-RIBOSYL CYCLASE, CYCLIC GUANOSINE DIPHOSPHATE-RIBOSE
著者Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
登録日2011-08-02
公開日2011-11-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWV
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Crystal structure of ADP-ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.3 angstrom
分子名称: ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
著者Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
登録日2011-08-03
公開日2011-11-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural studies of intermediates along the cyclization pathway of Aplysia ADP-ribosyl cyclase.
J. Mol. Biol., 415, 2012
3ZWP
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Crystal structure of ADP ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.1 angstrom
分子名称: ADP-RIBOSYL CYCLASE, GLYCEROL, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
著者Kotaka, M, Graeff, R, Zhang, L.H, Lee, H.C, Hao, Q.
登録日2011-08-02
公開日2011-11-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
2HCT
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Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities
分子名称: ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
著者Liu, Q, Kriksunov, I.A, Hao, Q, Graeff, R, Lee, H.C.
登録日2006-06-18
公開日2006-08-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities.
J.Biol.Chem., 281, 2006
2I67
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Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis
分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, ADP-ribosyl cyclase 1
著者Liu, Q, Kriksunov, I.A, Graeff, R, Munshi, C, Lee, H.C, Hao, Q.
登録日2006-08-28
公開日2006-09-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
J.Biol.Chem., 281, 2006
2I66
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Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis
分子名称: ADP-ribosyl cyclase 1, [(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4R,5S)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, [(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE
著者Liu, Q, Kriksunov, I.A, Graeff, R, Munshi, C, Lee, H.C, Hao, Q.
登録日2006-08-28
公開日2006-09-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
J.Biol.Chem., 281, 2006
2I65
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Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis
分子名称: ADP-ribosyl cyclase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Liu, Q, Kriksunov, I.A, Graeff, R, Munshi, C, Lee, H.C, Hao, Q.
登録日2006-08-28
公開日2006-09-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
J.Biol.Chem., 281, 2006
1R12
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Native Aplysia ADP ribosyl cyclase
分子名称: ADP-ribosyl cyclase
著者Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q.
登録日2003-09-23
公開日2004-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Structure, 12, 2004
1R0S
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BU of 1r0s by Molmil
Crystal structure of ADP-ribosyl cyclase Glu179Ala mutant
分子名称: ADP-ribosyl cyclase
著者Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q.
登録日2003-09-22
公開日2004-03-09
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Structure, 12, 2004
1R16
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Aplysia ADP ribosyl cyclase with bound pyridylcarbinol and R5P
分子名称: 3-PYRIDINYLCARBINOL, ADP-ribosyl cyclase, ANY 5'-MONOPHOSPHATE NUCLEOTIDE
著者Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q.
登録日2003-09-23
公開日2004-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Structure, 12, 2004
1R15
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Aplysia ADP ribosyl cyclase with bound nicotinamide and R5P
分子名称: ADP-ribosyl cyclase, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, NICOTINAMIDE
著者Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q.
登録日2003-09-23
公開日2004-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Structure, 12, 2004
2O3U
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Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38
分子名称: 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYD ROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2- YL]PYRIDINIUM, ADP-ribosyl cyclase 1
著者Liu, Q, Kriksunov, I.A, Graeff, R, Lee, H.C, Hao, Q.
登録日2006-12-01
公開日2006-12-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282, 2007
2O3S
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Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38
分子名称: ADP-ribosyl cyclase 1, CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE
著者Liu, Q, Kriksunov, I.A, Graeff, R, Lee, H.C, Hao, Q.
登録日2006-12-01
公開日2006-12-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282, 2007

 

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