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PDB: 300 件
5SVK
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Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, open state
分子名称: (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
登録日2016-08-06
公開日2016-09-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.773 Å)
主引用文献X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5SVT
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Anomalous Cs+ signal reveals the site of Na+ ion entry to the channel pore of the human P2X3 ion channel through the extracellular fenestrations
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, P2X purinoceptor 3, ...
著者Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
登録日2016-08-07
公開日2016-09-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.794 Å)
主引用文献X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5SVL
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Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, closed (desensitized) state
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
登録日2016-08-06
公開日2016-10-05
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5SVS
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Anomalous Mn2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated human P2X3 ion channel
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ...
著者Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
登録日2016-08-07
公開日2016-09-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (4.025 Å)
主引用文献X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5VOV
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Structure of AMPA receptor-TARP complex
分子名称: Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
著者Zhao, Y, Chen, S, Wang, Y.S, Shekhar, M, Tajkhorshid, E, Gouaux, E.
登録日2017-05-03
公開日2017-07-12
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (7.7 Å)
主引用文献Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM.
Cell, 170, 2017
1N0T
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X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution.
分子名称: (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID, ACETATE ION, Glutamate receptor 2, ...
著者Hogner, A, Greenwood, J.R, Liljefors, T, Lunn, M.-L, Egebjerg, J, Larsen, I.K, Gouaux, E, Kastrup, J.S.
登録日2002-10-15
公開日2003-03-04
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.
J.Med.Chem., 46, 2003
6AWQ
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Anomalous chloride signal reveals the position of sertraline complexed with the serotonin transporter at the central site
分子名称: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody FAB heavy chain, ...
著者Coleman, J.A, Gouaux, E.
登録日2017-09-06
公開日2017-10-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4.046 Å)
主引用文献Structural basis for recognition of diverse antidepressants by the human serotonin transporter.
Nat. Struct. Mol. Biol., 25, 2018
6AVE
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Structure of an acid sensing ion channel in a resting state at high pH
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1
著者Yoder, N, Yoshioka, C, Gouaux, E.
登録日2017-09-02
公開日2018-03-21
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Gating mechanisms of acid-sensing ion channels.
Nature, 555, 2018
6AWN
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X-ray structure of the S439T human serotonin transporter complexed with paroxetine at the central site
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody FAB heavy chain, 8B6 antibody FAB light chain, ...
著者Coleman, J.A, Gouaux, E.
登録日2017-09-06
公開日2017-10-25
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.62 Å)
主引用文献Structural basis for recognition of diverse antidepressants by the human serotonin transporter.
Nat. Struct. Mol. Biol., 25, 2018
6AWP
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X-ray structure of the ts3 human serotonin transporter complexed with fluvoxamine at the central site
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody FAB heavy chain, 8B6 antibody FAB light chain, ...
著者Coleman, J.A, Gouaux, E.
登録日2017-09-06
公開日2017-10-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural basis for recognition of diverse antidepressants by the human serotonin transporter.
Nat. Struct. Mol. Biol., 25, 2018
6AWO
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BU of 6awo by Molmil
X-ray structure of the ts3 human serotonin transporter complexed with sertraline at the central site
分子名称: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody FAB heavy chain, ...
著者Coleman, J.A, Gouaux, E.
登録日2017-09-06
公開日2017-10-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.534 Å)
主引用文献Structural basis for recognition of diverse antidepressants by the human serotonin transporter.
Nat. Struct. Mol. Biol., 25, 2018
6CMC
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BU of 6cmc by Molmil
Barium sites in the structure of a desensitized acid sensing ion channel
分子名称: Acid-sensing ion channel 1, CHLORIDE ION
著者Yoder, N, Gouaux, E.
登録日2018-03-03
公開日2018-08-08
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.671 Å)
主引用文献Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography.
PLoS ONE, 13, 2018
1MS7
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BU of 1ms7 by Molmil
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate
分子名称: (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID, Glutamate receptor subunit 2, ZINC ION
著者Kasper, C, Lunn, M.-L, Liljefors, T, Gouaux, E, Egebjerg, J, Kastrup, J.S.
登録日2002-09-19
公開日2003-07-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists
FEBS Lett., 531, 2002
1NNK
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BU of 1nnk by Molmil
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions.
分子名称: 3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE, CHLORIDE ION, Glutamate receptor 2, ...
著者Lunn, M.-L, Hogner, A, Stensbol, T.B, Gouaux, E, Egebjerg, J, Kastrup, J.S.
登録日2003-01-14
公開日2003-03-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Three-Dimensional Structure of the Ligand-Binding Core of GluR2 in Complex with the Agonist (S)-ATPA: Implications for Receptor Subunit Selectivity.
J.Med.Chem., 46, 2003
1XEZ
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BU of 1xez by Molmil
Crystal Structure Of The Vibrio Cholerae Cytolysin (HlyA) Pro-Toxin With Octylglucoside Bound
分子名称: hemolysin, octyl beta-D-glucopyranoside
著者Olson, R, Gouaux, E.
登録日2004-09-13
公開日2005-06-14
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of the Vibrio cholerae Cytolysin (VCC) Pro-toxin and its Assembly into a Heptameric Transmembrane Pore
J.Mol.Biol., 350, 2005
1XFH
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BU of 1xfh by Molmil
Structure of glutamate transporter homolog from Pyrococcus horikoshii
分子名称: proton glutamate symport protein
著者Yernool, D, Boudker, O, Jin, Y, Gouaux, E.
登録日2004-09-14
公開日2004-10-26
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structure of a glutamate transporter homologue from Pyrococcus horikoshii
Nature, 431, 2004
1Y20
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Crystal structure of the NR1 ligand-binding core in complex with ACPC
分子名称: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, Glutamate [NMDA] receptor subunit zeta 1
著者Inanobe, A, Gouaux, E.
登録日2004-11-19
公開日2005-07-12
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Mechanism of Partial Agonist Action at the NR1 Subunit of NMDA Receptors.
Neuron, 47, 2005
1Y1M
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Crystal structure of the NR1 ligand binding core in complex with cycloleucine
分子名称: 1-AMINOCYCLOPENTANECARBOXYLIC ACID, Glutamate [NMDA] receptor subunit zeta 1
著者Inanobe, A, Gouaux, E.
登録日2004-11-18
公開日2005-07-12
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Mechanism of Partial Agonist Action at the NR1 Subunit of NMDA Receptors.
Neuron, 47, 2005
1Y1Z
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Crystal structure of the NR1 ligand binding core in complex with ACBC
分子名称: 1-AMINOCYCLOBUTANECARBOXLIC ACID, Glutamate [NMDA] receptor subunit zeta 1
著者Inanobe, A, Gouaux, E.
登録日2004-11-19
公開日2005-07-12
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Mechanism of Partial Agonist Action at the NR1 Subunit of NMDA Receptors.
Neuron, 47, 2005
1NNP
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X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.
分子名称: 3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE, Glutamate receptor 2, SULFATE ION
著者Lunn, M.L, Hogner, A, Stensbol, T.B, Gouaux, E, Egebjerg, J, Kastrup, J.S.
登録日2003-01-14
公開日2003-03-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Three-Dimensional Structure of the Ligand-Binding Core of GluR2 in Complex with the Agonist (S)-ATPA: Implications for Receptor Subunit Selectivity.
J.Med.Chem., 46, 2003
2A65
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Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
分子名称: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ...
著者Yamashita, A, Singh, S.K, Kawate, T, Jin, Y, Gouaux, E.
登録日2005-07-01
公開日2005-08-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of a bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters.
Nature, 437, 2005
2A5S
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BU of 2a5s by Molmil
Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate
分子名称: GLUTAMIC ACID, N-methyl-D-aspartate receptor NMDAR2A subunit
著者Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E.
登録日2005-06-30
公開日2005-11-15
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
2Q6H
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Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and clomipramine
分子名称: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ...
著者Singh, S.K, Yamashita, A, Gouaux, E.
登録日2007-06-05
公開日2007-08-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
5IPT
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BU of 5ipt by Molmil
Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 5
分子名称: Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a
著者Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E.
登録日2016-03-09
公開日2016-04-20
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (14.1 Å)
主引用文献Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
5I66
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X-ray structure of the Fab fragment of 8B6, a murine monoclonal antibody specific for the human serotonin transporter
分子名称: 8B6 antibody, heavy chain, light chain
著者Coleman, J.A, Green, E.M, Gouaux, E.
登録日2016-02-16
公開日2016-04-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.624 Å)
主引用文献X-ray structures and mechanism of the human serotonin transporter.
Nature, 532, 2016

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