1LTX
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![BU of 1ltx by Molmil](/molmil-images/mine/1ltx) | Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid | 分子名称: | AAAA, CHLORIDE ION, FARNESYL, ... | 著者 | Pylypenko, O, Rak, A, Reents, R, Niculae, A, Thoma, N.H, Waldmann, H, Schlichting, I, Goody, R.S, Alexandrov, K. | 登録日 | 2002-05-21 | 公開日 | 2003-05-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of Rab Escort Protein-1 in Complex with Rab Geranylgeranyltransferase Mol.Cell, 11, 2003
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1VG9
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![BU of 1vg9 by Molmil](/molmil-images/mine/1vg9) | The crystal structures of the REP-1 protein in complex with C-terminally truncated Rab7 protein | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. | 登録日 | 2004-04-23 | 公開日 | 2004-07-20 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease Cell(Cambridge,Mass.), 117, 2004
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4OOJ
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![BU of 4ooj by Molmil](/molmil-images/mine/4ooj) | Crystal structure of the N-terminal domain of the Legionella pneumophila protein SidC at 2.4A resolution | 分子名称: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, SidC, ... | 著者 | Gazdag, E.M, Shoebel, S, Shkumatov, A.V, Goody, R.S, Itzen, A. | 登録日 | 2014-02-03 | 公開日 | 2014-02-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The structure of the N-terminal domain of the Legionella protein SidC J.Struct.Biol., 186, 2014
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3CPH
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![BU of 3cph by Molmil](/molmil-images/mine/3cph) | Crystal structure of Sec4 in complex with Rab-GDI | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rab GDP-dissociation inhibitor, ... | 著者 | Kravchenko, S, Ignatev, A, Goody, R.S, Rak, A, Pylypenko, O. | 登録日 | 2008-03-31 | 公開日 | 2008-05-06 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism. J.Biol.Chem., 283, 2008
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5O74
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![BU of 5o74 by Molmil](/molmil-images/mine/5o74) | Crystal structure of human Rab1b covalently bound to the GEF domain of DrrA/SidM from Legionella pneumophila in the presence of GDP | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Multifunctional virulence effector protein DrrA, Ras-related protein Rab-1B | 著者 | Cigler, M, Mueller, T, Horn-Ghetko, D, von Wrisberg, M.K, Fottner, M, Goody, R.S, Itzen, A, Mueller, M.P, Lang, K. | 登録日 | 2017-06-08 | 公開日 | 2017-10-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo. Angew. Chem. Int. Ed. Engl., 56, 2017
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3C72
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![BU of 3c72 by Molmil](/molmil-images/mine/3c72) | Engineered RabGGTase in complex with a peptidomimetic inhibitor | 分子名称: | CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... | 著者 | Guo, Z, Wu, Y.W, Tan, K.T, Bon, R.S, Guiu-Rozas, E, Delon, C, Nguyen, U.T, Wetzel, S, Arndt, S, Goody, R.S, Blankenfeldt, W, Alexandrov, K, Waldmann, H. | 登録日 | 2008-02-06 | 公開日 | 2008-07-22 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Angew.Chem.Int.Ed.Engl., 47, 2008
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5LPN
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![BU of 5lpn by Molmil](/molmil-images/mine/5lpn) | Structure of human Rab10 in complex with the bMERB domain of Mical-1 | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Protein-methionine sulfoxide oxidase MICAL1, ... | 著者 | Rai, A, Oprisko, A, Campos, J, Fu, Y, Friese, T, Itzen, A, Goody, R.S, Mueller, M.P, Gazdag, E.M. | 登録日 | 2016-08-14 | 公開日 | 2016-08-24 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | bMERB domains are bivalent Rab8 family effectors evolved by gene duplication. Elife, 5, 2016
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6FSF
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![BU of 6fsf by Molmil](/molmil-images/mine/6fsf) | Crystal structure of the tandem PX-PH-domains of Bem3 from Saccharomyces cerevisiae | 分子名称: | GTPase-activating protein BEM3 | 著者 | Ali, I, Eu, S, Koch, D, Bleimling, N, Goody, R.S, Mueller, M.P. | 登録日 | 2018-02-19 | 公開日 | 2018-05-02 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae. Acta Crystallogr F Struct Biol Commun, 74, 2018
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4EHM
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![BU of 4ehm by Molmil](/molmil-images/mine/4ehm) | RabGGTase in complex with covalently bound Psoromic acid | 分子名称: | 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid, CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, ... | 著者 | Guo, Z, Deraeve, C, Bon, R.S, Alexandrov, K, Waldmann, H, Wu, Y.W, Goody, R.S, Blankenfeldt, W. | 登録日 | 2012-04-02 | 公開日 | 2012-05-30 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase J.Am.Chem.Soc., 134, 2012
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3TMK
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![BU of 3tmk by Molmil](/molmil-images/mine/3tmk) | CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION | 分子名称: | P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, THYMIDYLATE KINASE | 著者 | Lavie, A, Schlichting, I, Konrad, M, Goody, R.S, Brundiers, R, Reinstein, J. | 登録日 | 1998-01-26 | 公開日 | 1999-02-16 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation. Biochemistry, 37, 1998
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821P
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![BU of 821p by Molmil](/molmil-images/mine/821p) | THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLYCINE-12 MUTANT OF P21H-RAS | 分子名称: | C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Scheidig, A.J, Krengel, U, Pai, E.F, Kabsch, W, Wittinghofer, A, Goody, R.S. | 登録日 | 1993-03-29 | 公開日 | 1994-01-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry, 32, 1993
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8A4C
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![BU of 8a4c by Molmil](/molmil-images/mine/8a4c) | Structure of human Rep15:Rab3B complex. | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Rab15 effector protein, ... | 著者 | Rai, A, Vetter, I.R, Goody, R.S. | 登録日 | 2022-06-10 | 公開日 | 2022-08-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector. Nat Commun, 13, 2022
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8A4B
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![BU of 8a4b by Molmil](/molmil-images/mine/8a4b) | Structure of human Rep15:Rab3B_Q81L complex. | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rab15 effector protein, ... | 著者 | Rai, A, Vetter, I.R, Goody, R.S. | 登録日 | 2022-06-10 | 公開日 | 2022-08-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector. Nat Commun, 13, 2022
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8A4A
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![BU of 8a4a by Molmil](/molmil-images/mine/8a4a) | Structure of human Rep15 in complex with bovine Rab3C. | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Rab15 effector protein, ... | 著者 | Rai, A, Vetter, I.R, Goody, R.S. | 登録日 | 2022-06-10 | 公開日 | 2022-08-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector. Nat Commun, 13, 2022
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1AGP
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![BU of 1agp by Molmil](/molmil-images/mine/1agp) | THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLY-12 MUTANT OF P21-H-RAS | 分子名称: | C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Franken, S.M, Scheidig, A.J, Wittinghofer, A, Goody, R.S. | 登録日 | 1993-03-29 | 公開日 | 1994-04-30 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry, 32, 1993
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1E99
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![BU of 1e99 by Molmil](/molmil-images/mine/1e99) | Human thymidylate kinase complexed with AZTMP and ADP | 分子名称: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reinstein, J, Goody, R.S, Konrad, M, Schlichting, I. | 登録日 | 2000-10-10 | 公開日 | 2001-10-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E9E
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![BU of 1e9e by Molmil](/molmil-images/mine/1e9e) | Mutant human thymidylate kinase (F105Y) complexed with dTMP and ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ... | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | 登録日 | 2000-10-11 | 公開日 | 2001-10-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E9D
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![BU of 1e9d by Molmil](/molmil-images/mine/1e9d) | Mutant human thymidylate kinase (F105Y) complexed with AZTMP and ADP | 分子名称: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | 登録日 | 2000-10-10 | 公開日 | 2001-10-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E98
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![BU of 1e98 by Molmil](/molmil-images/mine/1e98) | Wild type human thymidylate kinase complexed with AZTMP and ADP | 分子名称: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | 登録日 | 2000-10-10 | 公開日 | 2001-10-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E9F
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![BU of 1e9f by Molmil](/molmil-images/mine/1e9f) | Mutant human thymidylate kinase complexed with TMP and ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ... | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reinstein, J, Goody, R.S, Konrad, M, Schlichting, I. | 登録日 | 2000-10-11 | 公開日 | 2001-10-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E9C
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![BU of 1e9c by Molmil](/molmil-images/mine/1e9c) | Mutant human thymidylate kinase complexed with TMP and APPNP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | 登録日 | 2000-10-10 | 公開日 | 2001-10-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E9A
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![BU of 1e9a by Molmil](/molmil-images/mine/1e9a) | Human thymidylate kinase complexed with the bisubstrate inhibitor AZTP5A | 分子名称: | MAGNESIUM ION, P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE, THYMIDYLATE KINASE | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | 登録日 | 2000-10-10 | 公開日 | 2001-10-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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1E9B
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![BU of 1e9b by Molmil](/molmil-images/mine/1e9b) | Human thymidylate kinase complexed with AZTMP and APPNP | 分子名称: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I. | 登録日 | 2000-10-10 | 公開日 | 2001-10-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp J.Mol.Biol., 304, 2000
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3BW6
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![BU of 3bw6 by Molmil](/molmil-images/mine/3bw6) | Crystal structure of the longin domain of yeast Ykt6 | 分子名称: | SULFATE ION, Synaptobrevin homolog YKT6 | 著者 | Pylypenko, O, Schonichen, A, Ludwig, D, Ungermann, C, Goody, R.S, Rak, A, Geyer, M. | 登録日 | 2008-01-08 | 公開日 | 2008-04-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding. J.Mol.Biol., 377, 2008
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3N6O
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![BU of 3n6o by Molmil](/molmil-images/mine/3n6o) | Crystal structure of the GEF and P4M domain of DrrA/SidM from Legionella pneumophila | 分子名称: | SULFATE ION, guanine nucleotide exchange factor | 著者 | Schoebel, S, Blankenfeldt, W, Goody, R.S, Itzen, A. | 登録日 | 2010-05-26 | 公開日 | 2010-07-28 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA. Embo Rep., 11, 2010
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