1SOR
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![BU of 1sor by Molmil](/molmil-images/mine/1sor) | Aquaporin-0 membrane junctions reveal the structure of a closed water pore | Descriptor: | Aquaporin-0 | Authors: | Gonen, T, Sliz, P, Kistler, J, Cheng, Y, Walz, T. | Deposit date: | 2004-03-15 | Release date: | 2004-05-11 | Last modified: | 2023-08-23 | Method: | ELECTRON CRYSTALLOGRAPHY (3 Å) | Cite: | Aquaporin-0 membrane junctions reveal the structure of a closed water pore Nature, 429, 2004
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2B6P
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![BU of 2b6p by Molmil](/molmil-images/mine/2b6p) | X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state | Descriptor: | Lens fiber major intrinsic protein | Authors: | Gonen, T, Cheng, Y, Sliz, P, Hiroaki, Y, Fujiyoshi, Y, Harrison, S.C, Walz, T. | Deposit date: | 2005-10-03 | Release date: | 2005-12-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature, 438, 2005
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2B6O
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![BU of 2b6o by Molmil](/molmil-images/mine/2b6o) | Electron crystallographic structure of lens Aquaporin-0 (AQP0) (lens MIP) at 1.9A resolution, in a closed pore state | Descriptor: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Lens fiber major intrinsic protein | Authors: | Gonen, T, Cheng, Y, Sliz, P, Hiroaki, Y, Fujiyoshi, Y, Harrison, S.C, Walz, T. | Deposit date: | 2005-10-03 | Release date: | 2005-12-06 | Last modified: | 2023-08-23 | Method: | ELECTRON CRYSTALLOGRAPHY (1.9 Å) | Cite: | Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature, 438, 2005
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6M9I
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![BU of 6m9i by Molmil](/molmil-images/mine/6m9i) | L-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | Descriptor: | Ice nucleation protein | Authors: | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | Deposit date: | 2018-08-23 | Release date: | 2019-03-27 | Last modified: | 2024-03-13 | Method: | ELECTRON CRYSTALLOGRAPHY (0.9 Å) | Cite: | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ. IUCrJ, 6, 2019
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7SKW
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![BU of 7skw by Molmil](/molmil-images/mine/7skw) | Ab initio structure of triclinic lysozyme from electron-counted MicroED data | Descriptor: | Lysozyme C, NITRATE ION | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Hattne, J, Gonen, T. | Deposit date: | 2021-10-21 | Release date: | 2022-06-08 | Last modified: | 2022-06-22 | Method: | ELECTRON CRYSTALLOGRAPHY (0.87 Å) | Cite: | Ab initio phasing macromolecular structures using electron-counted MicroED data. Nat.Methods, 19, 2022
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7SKX
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![BU of 7skx by Molmil](/molmil-images/mine/7skx) | Ab initio structure of proteinase K from electron-counted MicroED data | Descriptor: | 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, CALCIUM ION, Proteinase K | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Hattne, J, Gonen, T. | Deposit date: | 2021-10-21 | Release date: | 2022-06-08 | Last modified: | 2022-06-22 | Method: | ELECTRON CRYSTALLOGRAPHY (1.5 Å) | Cite: | Ab initio phasing macromolecular structures using electron-counted MicroED data. Nat.Methods, 19, 2022
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8FYO
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![BU of 8fyo by Molmil](/molmil-images/mine/8fyo) | MicroED structure of Proteinase K from lamellae milled from multiple plasma sources | Descriptor: | CALCIUM ION, NITRATE ION, Proteinase K | Authors: | Martynowycz, M.W, Shiriaeva, A, Clabbers, M.T.B, Nicolas, W.J, Weaver, S.J, Hattne, J, Gonen, T. | Deposit date: | 2023-01-26 | Release date: | 2023-05-24 | Method: | ELECTRON CRYSTALLOGRAPHY (1.39 Å) | Cite: | A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals. Nat Commun, 14, 2023
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4ZNN
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![BU of 4znn by Molmil](/molmil-images/mine/4znn) | MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56 | Descriptor: | Alpha-synuclein | Authors: | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | Deposit date: | 2015-05-05 | Release date: | 2015-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON CRYSTALLOGRAPHY (1.41 Å) | Cite: | Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525, 2015
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5A3E
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![BU of 5a3e by Molmil](/molmil-images/mine/5a3e) | |
5I9S
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![BU of 5i9s by Molmil](/molmil-images/mine/5i9s) | MicroED structure of proteinase K at 1.75 A resolution | Descriptor: | Proteinase K, SULFATE ION | Authors: | Hattne, J, Shi, D, de la Cruz, M.J, Reyes, F.E, Gonen, T. | Deposit date: | 2016-02-20 | Release date: | 2016-06-08 | Last modified: | 2023-08-30 | Method: | ELECTRON CRYSTALLOGRAPHY (1.75 Å) | Cite: | Modeling truncated pixel values of faint reflections in MicroED images. J.Appl.Crystallogr., 49, 2016
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6EEX
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![BU of 6eex by Molmil](/molmil-images/mine/6eex) | L-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | Descriptor: | L-GSTSTA from ice nucleaction protein, inaZ | Authors: | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | Deposit date: | 2018-08-15 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ. IUCrJ, 6, 2019
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4UOT
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![BU of 4uot by Molmil](/molmil-images/mine/4uot) | Thermodynamic hyperstability in parametrically designed helical bundles | Descriptor: | DESIGNED HELICAL BUNDLE 5H2L | Authors: | Oberdorfer, G, Huang, P, Pei, X.Y, Xu, C, Gonen, T, Nannenga, B, DiMaio, D, Rogers, J, Luisi, B.F, Baker, D. | Deposit date: | 2014-06-09 | Release date: | 2014-11-05 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | High Thermodynamic Stability of Parametrically Designed Helical Bundles Science, 346, 2014
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4UOS
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![BU of 4uos by Molmil](/molmil-images/mine/4uos) | Thermodynamic hyperstability in parametrically designed helical bundles | Descriptor: | DESIGNED HELICAL BUNDLE | Authors: | Oberdorfer, G, Huang, P, Pei, X.Y, Xu, C, Gonen, T, Nannenga, B, DiMaio, D, Rogers, J, Luisi, B.F, Baker, D. | Deposit date: | 2014-06-09 | Release date: | 2014-11-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | High Thermodynamic Stability of Parametrically Designed Helical Bundles Science, 346, 2014
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8VD7
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![BU of 8vd7 by Molmil](/molmil-images/mine/8vd7) | MicroED structure of SARS-CoV-2 main protease (MPro/3CLPro) with missing cone eliminated by suspended drop | Descriptor: | 3C-like proteinase nsp5, CHLORIDE ION | Authors: | Bu, G, Gillman, C, Danelius, E, Hattne, J, Nannenga, B.L, Gonen, T. | Deposit date: | 2023-12-14 | Release date: | 2024-07-17 | Method: | ELECTRON CRYSTALLOGRAPHY (2.15 Å) | Cite: | Eliminating the missing cone challenge through innovative approaches. J Struct Biol X, 9, 2024
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7RM5
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![BU of 7rm5 by Molmil](/molmil-images/mine/7rm5) | MicroED structure of the human adenosine receptor at 2.8A | Descriptor: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a/Soluble cytochrome b562 chimera, CHOLESTEROL, ... | Authors: | Martynowycz, M.W, Shiriaeva, A, Ge, X, Hattne, J, Nannenga, B.L, Cherezov, V, Gonen, T. | Deposit date: | 2021-07-26 | Release date: | 2021-09-08 | Last modified: | 2023-10-18 | Method: | ELECTRON CRYSTALLOGRAPHY (2.79 Å) | Cite: | MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP. Proc.Natl.Acad.Sci.USA, 118, 2021
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8SDK
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![BU of 8sdk by Molmil](/molmil-images/mine/8sdk) | The MicroED structure of proteinase K crystallized by suspended drop crystallization | Descriptor: | CALCIUM ION, Proteinase K, SULFATE ION | Authors: | Gillman, C, Nicolas, W.J, Martynowycz, M.W, Gonen, T. | Deposit date: | 2023-04-06 | Release date: | 2023-05-31 | Last modified: | 2023-07-12 | Method: | ELECTRON CRYSTALLOGRAPHY (2.1 Å) | Cite: | Design and implementation of suspended drop crystallization. Iucrj, 10, 2023
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6U5G
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![BU of 6u5g by Molmil](/molmil-images/mine/6u5g) | MicroED structure of a FIB-milled CypA Crystal | Descriptor: | Peptidyl-prolyl cis-trans isomerase A | Authors: | Wolff, A.M, Martynowycz, M.W, Zhao, W, Gonen, T, Fraser, J.S, Thompson, M.C. | Deposit date: | 2019-08-27 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | ELECTRON CRYSTALLOGRAPHY (2.5 Å) | Cite: | Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals Iucrj, 7, 2020
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4RIL
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![BU of 4ril by Molmil](/molmil-images/mine/4ril) | Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 68-78, determined by electron diffraction | Descriptor: | Alpha-synuclein | Authors: | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | Deposit date: | 2014-10-06 | Release date: | 2015-08-26 | Last modified: | 2023-09-20 | Method: | ELECTRON CRYSTALLOGRAPHY (1.43 Å) | Cite: | Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525, 2015
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4JRE
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![BU of 4jre by Molmil](/molmil-images/mine/4jre) | Crystal structure of nitrate/nitrite exchanger NarK with nitrite bound | Descriptor: | Immunoglobulin Gamma-2a, Heavy chain, Immunoglobulin Kappa, ... | Authors: | Zheng, H, Wisedchaisri, G, Gonen, T. | Deposit date: | 2013-03-21 | Release date: | 2013-05-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of a nitrate/nitrite exchanger. Nature, 497, 2013
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4JR9
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![BU of 4jr9 by Molmil](/molmil-images/mine/4jr9) | Crystal structure of nitrate/nitrite exchanger NarK | Descriptor: | Immunoglobulin Gamma-2a, Heavy chain, Immunoglobulin Kappa, ... | Authors: | Zheng, H, Wisedchaisri, G, Gonen, T. | Deposit date: | 2013-03-21 | Release date: | 2013-05-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of a nitrate/nitrite exchanger. Nature, 497, 2013
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7KGV
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![BU of 7kgv by Molmil](/molmil-images/mine/7kgv) | Crystal structure of sodium-coupled neutral amino acid transporter SLC38A9 in the N-terminal plugged form | Descriptor: | Monoclonal antibody Fab heavy chain, Monoclonal antibody Fab light chain, Sodium-coupled neutral amino acid transporter 9 | Authors: | Lei, H, Mu, X, Hattne, J, Gonen, T. | Deposit date: | 2020-10-19 | Release date: | 2020-12-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | A conformational change in the N terminus of SLC38A9 signals mTORC1 activation. Structure, 29, 2021
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4QIQ
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![BU of 4qiq by Molmil](/molmil-images/mine/4qiq) | Crystal structure of D-xylose-proton symporter | Descriptor: | D-xylose-proton symporter, ZINC ION | Authors: | Wisedchaisri, G, Park, M, Iadanza, M.G, Zheng, H, Gonen, T. | Deposit date: | 2014-06-01 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.51 Å) | Cite: | Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE. Nat Commun, 5, 2014
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4TQL
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![BU of 4tql by Molmil](/molmil-images/mine/4tql) | Computationally designed three helix bundle | Descriptor: | Three helix bundle | Authors: | Nannenga, B.L, Oberdorfer, G, DiMaio, F, Baker, D, Gonen, T. | Deposit date: | 2014-06-11 | Release date: | 2014-10-15 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | High thermodynamic stability of parametrically designed helical bundles. Science, 346, 2014
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6MXF
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![BU of 6mxf by Molmil](/molmil-images/mine/6mxf) | MicroED structure of thiostrepton at 1.9 A resolution | Descriptor: | Thiostrepton | Authors: | Jones, C.G, Martynowycz, M.W, Hattne, J, Fulton, T, Stoltz, B.M, Rodriguez, J.A, Nelson, H.M, Gonen, T. | Deposit date: | 2018-10-30 | Release date: | 2018-11-21 | Last modified: | 2023-11-15 | Method: | ELECTRON CRYSTALLOGRAPHY (1.91 Å) | Cite: | The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination. ACS Cent Sci, 4, 2018
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6C9I
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![BU of 6c9i by Molmil](/molmil-images/mine/6c9i) | Single-Particle reconstruction of DARP14 - A designed protein scaffold displaying ~17kDa DARPin proteins - Scaffold | Descriptor: | DARP14 - Subunit A with DARPin, DARP14 - Subunit B | Authors: | Gonen, S, Liu, Y, Yeates, T.O, Gonen, T. | Deposit date: | 2018-01-26 | Release date: | 2018-03-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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