4EQ1
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![BU of 4eq1 by Molmil](/molmil-images/mine/4eq1) | Crystal Structure of the ARNT PAS-B homodimer | Descriptor: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Aryl hydrocarbon receptor nuclear translocator | Authors: | Gardner, K.H, Key, J.M. | Deposit date: | 2012-04-17 | Release date: | 2013-04-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules. Acs Chem.Biol., 8, 2013
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1CLD
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![BU of 1cld by Molmil](/molmil-images/mine/1cld) | DNA-binding protein | Descriptor: | CADMIUM ION, CD2-LAC9 | Authors: | Gardner, K.H, Coleman, J.E. | Deposit date: | 1995-06-06 | Release date: | 1995-09-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the Kluyveromyces lactis LAC9 Cd2 Cys6 DNA-binding domain. Nat.Struct.Biol., 2, 1995
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4PKY
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![BU of 4pky by Molmil](/molmil-images/mine/4pky) | ARNT/HIF transcription factor/coactivator complex | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, SULFATE ION, ... | Authors: | Tomchick, D.R, Partch, C.L, Gardner, K.H. | Deposit date: | 2014-05-15 | Release date: | 2015-02-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Coiled-coil Coactivators Play a Structural Role Mediating Interactions in Hypoxia-inducible Factor Heterodimerization. J.Biol.Chem., 290, 2015
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2VLG
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![BU of 2vlg by Molmil](/molmil-images/mine/2vlg) | KinA PAS-A domain, homodimer | Descriptor: | ACETATE ION, CHLORIDE ION, SPORULATION KINASE A | Authors: | Lee, J, Tomchick, D.R, Brautigam, C.A, Machius, M, Kort, R, Hellingwerf, K.J, Gardner, K.H. | Deposit date: | 2008-01-14 | Release date: | 2008-03-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Changes at the Kina Pas-A Dimerization Interface Influence Histidine Kinase Function. Biochemistry, 47, 2008
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4GS9
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![BU of 4gs9 by Molmil](/molmil-images/mine/4gs9) | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with an inactive benzoxadiazole antagonist | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, ... | Authors: | Scheuermann, T.H, Gardner, K.H. | Deposit date: | 2012-08-27 | Release date: | 2013-04-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Development of Inhibitors of the PAS-B Domain of the HIF-2 alpha Transcription Factor J.Med.Chem., 56, 2013
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2BYC
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![BU of 2byc by Molmil](/molmil-images/mine/2byc) | BlrB - a BLUF protein, dark state structure | Descriptor: | BLUE-LIGHT RECEPTOR OF THE BLUF-FAMILY, FLAVIN MONONUCLEOTIDE | Authors: | Jung, A, Domratcheva, T, Tarutina, M, Wu, Q, Ko, W.H, Shoeman, R.L, Gomelsky, M, Gardner, K.H, Schlichting, I. | Deposit date: | 2005-07-29 | Release date: | 2005-08-24 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of a Bacterial Bluf Photoreceptor: Insights Into Blue Light-Mediated Signal Transduction. Proc.Natl.Acad.Sci.USA, 102, 2005
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2N9U
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![BU of 2n9u by Molmil](/molmil-images/mine/2n9u) | |
2MSW
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![BU of 2msw by Molmil](/molmil-images/mine/2msw) | |
2F9S
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![BU of 2f9s by Molmil](/molmil-images/mine/2f9s) | 2nd Crystal Structure Of A Soluble Domain Of ResA In The Oxidised Form | Descriptor: | Thiol-disulfide oxidoreductase resA | Authors: | Colbert, C.L, Wu, Q, Erbel, P.J.A, Gardner, K.H, Deisenhofer, J. | Deposit date: | 2005-12-06 | Release date: | 2006-04-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.401 Å) | Cite: | Mechanism of substrate specificity in Bacillus subtilis ResA, a thioredoxin-like protein involved in cytochrome c maturation Proc.Natl.Acad.Sci.USA, 103, 2006
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3P4K
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![BU of 3p4k by Molmil](/molmil-images/mine/3p4k) | The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution | Descriptor: | MAP kinase 14, Mitogen-activated protein kinase 14 | Authors: | Akella, R, Min, X, Wu, Q, Gardner, K.H, Goldsmith, E.J. | Deposit date: | 2010-10-06 | Release date: | 2011-01-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.304 Å) | Cite: | The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution Structure, 18, 2010
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2KB2
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![BU of 2kb2 by Molmil](/molmil-images/mine/2kb2) | BlrP1 BLUF | Descriptor: | BlrP1, FLAVIN MONONUCLEOTIDE | Authors: | Wu, Q, Gardner, K.H. | Deposit date: | 2008-11-19 | Release date: | 2009-04-07 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure and insight into blue light-induced changes in the BlrP1 BLUF domain Biochemistry, 48, 2009
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2K7S
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![BU of 2k7s by Molmil](/molmil-images/mine/2k7s) | |
5KIZ
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![BU of 5kiz by Molmil](/molmil-images/mine/5kiz) | |
4XT2
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![BU of 4xt2 by Molmil](/molmil-images/mine/4xt2) | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a tetrazole-containing antagonist | Descriptor: | (5S,7R)-5,7-bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | Authors: | Scheuermann, T.H, Gardner, K.H. | Deposit date: | 2015-01-22 | Release date: | 2015-12-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.698 Å) | Cite: | Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2. J.Med.Chem., 58, 2015
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1X0O
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![BU of 1x0o by Molmil](/molmil-images/mine/1x0o) | human ARNT C-terminal PAS domain | Descriptor: | Aryl hydrocarbon receptor nuclear translocator | Authors: | Card, P.B, Erbel, P.J, Gardner, K.H. | Deposit date: | 2005-03-25 | Release date: | 2005-10-25 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural Basis of ARNT PAS-B Dimerization: Use of a Common Beta-sheet Interface for Hetero- and Homodimerization. J.Mol.Biol., 353, 2005
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1YMZ
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![BU of 1ymz by Molmil](/molmil-images/mine/1ymz) | CC45, An Artificial WW Domain Designed Using Statistical Coupling Analysis | Descriptor: | CC45 | Authors: | Socolich, M, Lockless, S.W, Russ, W.P, Lee, H, Gardner, K.H, Ranganathan, R. | Deposit date: | 2005-01-22 | Release date: | 2005-09-27 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Evolutionary information for specifying a protein fold. Nature, 437, 2005
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2A24
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![BU of 2a24 by Molmil](/molmil-images/mine/2a24) | HADDOCK Structure of HIF-2a/ARNT PAS-B Heterodimer | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain protein 1 | Authors: | Card, P.B, Erbel, P.J, Gardner, K.H. | Deposit date: | 2005-06-21 | Release date: | 2006-01-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization. J.Mol.Biol., 353, 2005
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8G4A
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![BU of 8g4a by Molmil](/molmil-images/mine/8g4a) | |
2HV1
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![BU of 2hv1 by Molmil](/molmil-images/mine/2hv1) | HADDOCK structure of ARNT PAS-B Homodimer | Descriptor: | Aryl hydrocarbon receptor nuclear translocator | Authors: | Card, P.B, Gardner, K.H. | Deposit date: | 2006-07-27 | Release date: | 2007-08-07 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Practical aspects of using paramagnetic relaxation enhancements for protein docking: Application to the ARNT PAS-B homodimer To be Published
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2LRU
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![BU of 2lru by Molmil](/molmil-images/mine/2lru) | Solution Structure of the WNK1 Autoinhibitory Domain | Descriptor: | Serine/threonine-protein kinase WNK1 | Authors: | Moon, T.M, Correa, F, Gardner, K.H, Goldsmith, E.J. | Deposit date: | 2012-04-13 | Release date: | 2012-05-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure of the WNK1 Autoinhibitory Domain, a WNK-Specific PF2 Domain. J.Mol.Biol., 425, 2013
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4R39
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![BU of 4r39 by Molmil](/molmil-images/mine/4r39) | |
4R38
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![BU of 4r38 by Molmil](/molmil-images/mine/4r38) | |
4R3A
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![BU of 4r3a by Molmil](/molmil-images/mine/4r3a) | Erythrobacter litoralis EL346 blue-light activated histidine kinase | Descriptor: | Blue-light-activated histidine kinase 2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Tomchick, D.R, Rivera-Cancel, G, Gardner, K.H. | Deposit date: | 2014-08-14 | Release date: | 2014-12-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation. Proc.Natl.Acad.Sci.USA, 111, 2014
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4GHI
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![BU of 4ghi by Molmil](/molmil-images/mine/4ghi) | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a benzoxadiazole antagonist | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine | Authors: | Scheuermann, T.H, Key, J, Tambar, U.K, Bruick, R.K, Gardner, K.H. | Deposit date: | 2012-08-07 | Release date: | 2013-02-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat.Chem.Biol., 9, 2013
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3F1P
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![BU of 3f1p by Molmil](/molmil-images/mine/3f1p) | Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | Authors: | Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H. | Deposit date: | 2008-10-28 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.17 Å) | Cite: | Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc.Natl.Acad.Sci.USA, 106, 2009
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