8J8K
| Membrane bound PRTase, C3 symmetry, acceptor bound | Descriptor: | Decaprenyl-phosphate phosphoribosyltransferase, MONO-TRANS, OCTA-CIS DECAPRENYL-PHOSPHATE | Authors: | Wu, F.Y, Gao, S, Zhang, L, Rao, Z.H. | Deposit date: | 2023-05-01 | Release date: | 2024-02-07 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis. Nat Microbiol, 9, 2024
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8Q71
| Crystal structure of SARS-CoV-2 main protease (MPro) in complex with the inhibitor GC-67 | Descriptor: | (2~{S})-1-(3,4-dichlorophenyl)-4-(4-methoxypyridin-3-yl)carbonyl-~{N}-(thiophen-2-ylmethyl)piperazine-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Strater, N, Muller, C.E, Sylvester, K, Weisse, R.H, Useini, A, Gao, S, Song, L, Liu, Z, Zhan, P. | Deposit date: | 2023-08-15 | Release date: | 2023-12-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.322 Å) | Cite: | Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability. J.Med.Chem., 66, 2023
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5XDP
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7EGQ
| Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading | Descriptor: | Helicase, MAGNESIUM ION, Non-structural protein 10, ... | Authors: | Yan, L.M, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. | Deposit date: | 2021-03-25 | Release date: | 2021-07-21 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Cell, 184, 2021
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7EIZ
| Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading | Descriptor: | Helicase, MAGNESIUM ION, Non-structural protein 10, ... | Authors: | Yan, L, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. | Deposit date: | 2021-04-01 | Release date: | 2021-09-22 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY | Cite: | Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading Cell, 184, 2021
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6JFK
| GDP bound Mitofusin2 (MFN2) | Descriptor: | CITRIC ACID, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Li, Y.J, Cao, Y.L, Feng, J.X, Qi, Y.B, Meng, S.X, Yang, J.F, Zhong, Y.T, Kang, S.S, Chen, X.X, Lan, L, Luo, L, Yu, B, Chen, S.D, Chan, D.C, Hu, J.J, Gao, S. | Deposit date: | 2019-02-10 | Release date: | 2019-11-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.997 Å) | Cite: | Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nat Commun, 10, 2019
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6JFL
| Nucleotide-free Mitofusin2 (MFN2) | Descriptor: | CALCIUM ION, GLYCEROL, Mitofusin-2,cDNA FLJ57997, ... | Authors: | Li, Y.J, Cao, Y.L, Feng, J.X, Qi, Y.B, Meng, S.X, Yang, J.F, Zhong, Y.T, Kang, S.S, Chen, X.X, Lan, L, Luo, L, Yu, B, Chen, S.D, Chan, D.C, Hu, J.J, Gao, S. | Deposit date: | 2019-02-10 | Release date: | 2019-11-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.806 Å) | Cite: | Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nat Commun, 10, 2019
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6JFM
| Mitofusin2 (MFN2)_T111D | Descriptor: | ACETATE ION, CALCIUM ION, Mitofusin-2,Mitofusin-2 | Authors: | Li, Y.J, Cao, Y.L, Feng, J.X, Qi, Y.B, Meng, S.X, Yang, J.F, Zhong, Y.T, Kang, S.S, Chen, X.X, Lan, L, Luo, L, Yu, B, Chen, S.D, Chan, D.C, Hu, J.J, Gao, S. | Deposit date: | 2019-02-10 | Release date: | 2019-11-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nat Commun, 10, 2019
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5GTM
| Modified human MxA, nucleotide-free form | Descriptor: | Interferon-induced GTP-binding protein Mx1 | Authors: | Chen, Y, Gao, S. | Deposit date: | 2016-08-22 | Release date: | 2017-05-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.896 Å) | Cite: | Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET Nat Commun, 8, 2017
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5HWH
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5HWG
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7CQZ
| crystal structure of mouse FAM46C (TENT5C) | Descriptor: | CHLORIDE ION, GLYCEROL, Terminal nucleotidyltransferase 5C | Authors: | Hu, J.L, Zhang, H, Gao, S. | Deposit date: | 2020-08-12 | Release date: | 2021-06-09 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.34969759 Å) | Cite: | Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C. Cancer Commun (Lond), 41, 2021
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5YD0
| Crystal structure of Schlafen 13 (SLFN13) N'-domain | Descriptor: | Schlafen 8, ZINC ION | Authors: | Yang, J.-Y, Gao, S. | Deposit date: | 2017-09-09 | Release date: | 2018-03-28 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.182 Å) | Cite: | Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control Nat Commun, 9, 2018
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6LBJ
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6LBK
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7WNN
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7WNW
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7KH0
| Cryo-EM structure of the human arginine vasopressin AVP-vasopressin receptor V2R-Gs signaling complex | Descriptor: | Arg-vasopressin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, L, Xu, J, Gao, S, Sun, D, Liu, H, Liu, Z, Du, Y, Zhang, C. | Deposit date: | 2020-10-19 | Release date: | 2021-05-26 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structure of the AVP-vasopressin receptor 2-G s signaling complex. Cell Res., 31, 2021
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7CUX
| Crystal structure of human Schlafen 5 N'-terminal domain (SLFN5-N) involved in ssRNA cleaving and DNA binding | Descriptor: | Schlafen family member 5, ZINC ION | Authors: | Yang, J.Y, Luo, M, Ou, J.Y, Wang, Z.W, Gao, S. | Deposit date: | 2020-08-25 | Release date: | 2021-08-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.29477072 Å) | Cite: | Crystal structure of human Schlafen 5 N'-terminal domain (SLFN5-N) involved in ssRNA cleaving and DNA binding To Be Published
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7E8L
| The structure of Spodoptera litura chemosensory protein | Descriptor: | Putative chemosensory protein CSP8 | Authors: | Xie, W, Jia, Q, Zeng, H, Xiao, N, Tang, J, Gao, S, Zhang, J. | Deposit date: | 2021-03-02 | Release date: | 2022-03-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Crystal Structure of the Spodoptera litura Chemosensory Protein CSP8. Insects, 12, 2021
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6KZF
| Racemic X-ray Structure of Calcicludine | Descriptor: | D-calcicludine, Kunitz-type serine protease inhibitor homolog calcicludine | Authors: | Qu, Q, Gao, S, Liu, L. | Deposit date: | 2019-09-24 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy Angew.Chem.Int.Ed.Engl., 59, 2020
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6M49
| cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol. | Descriptor: | 25-HYDROXYCHOLESTEROL, Insulin-induced gene 2 protein, Sterol regulatory element-binding protein cleavage-activating protein,Sterol regulatory element-binding protein cleavage-activating protein | Authors: | Yan, R, Cao, P, Song, W, Qian, H, Du, X, Coates, H.W, Zhao, X, Li, Y, Gao, S, Gong, X, Liu, X, Sui, J, Lei, J, Yang, H, Brown, A.J, Zhou, Q, Yan, C, Yan, N. | Deposit date: | 2020-03-06 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science, 371, 2021
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6LQN
| EBV tegument protein BBRF2 | Descriptor: | Cytoplasmic envelopment protein 1, NITRATE ION, SULFATE ION | Authors: | He, H.P, Luo, M, Cao, Y.L, Gao, S. | Deposit date: | 2020-01-14 | Release date: | 2020-10-07 | Last modified: | 2021-04-21 | Method: | X-RAY DIFFRACTION (1.600022 Å) | Cite: | Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment. Nat Commun, 11, 2020
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6LQO
| EBV tegument protein BBRF2/BSRF1 complex | Descriptor: | ACETATE ION, Cytoplasmic envelopment protein 1, GLYCEROL, ... | Authors: | He, H.P, Luo, M, Cao, Y.L, Gao, S. | Deposit date: | 2020-01-14 | Release date: | 2020-10-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.0911262 Å) | Cite: | Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment. Nat Commun, 11, 2020
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