7CQZ

crystal structure of mouse FAM46C (TENT5C)

Summary for 7CQZ

• Entry DOI: 10.2210/pdb7cqz/pdb
• Descriptor: Terminal nucleotidyltransferase 5C, CHLORIDE ION, GLYCEROL, ... (4 entities in total)
• Functional Keywords: non-canonical poly(a) polymerase, gene regulation
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 1
• Total formula weight: 40145.09

Authors

Hu, J.L.,Zhang, H.,Gao, S. (deposition date: 2020-08-12, release date: 2021-06-09, Last modification date: 2024-03-27)

Primary citation

Zhang, H.,Zhang, S.H.,Hu, J.L.,Wu, Y.T.,Ma, X.Y.,Chen, Y.,Yu, B.,Liao, S.,Huang, H.,Gao, S.
Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C.
Cancer Commun (Lond), 41:615-630, 2021

PubMed Abstract: Multiple myeloma (MM) is a hematologic malignancy characterized by the accumulation of aberrant plasma cells within the bone marrow. The high frequent mutation of family with sequence similarity 46, member C (FAM46C) is closely related with the occurrence and progression of MM. Recently, FAM46C has been identified as a non-canonical poly(A) polymerase (PAP) that functions as a tumor suppressor in MM. This study aimed to elucidate the structural features of this novel non-canonical PAP and how MM-related mutations affect the structural and biochemical properties of FAM46C, eventually advancing our understandings towards FAM46C mutation-related MM occurrence.

PubMed: 34048638
DOI: 10.1002/cac2.12163

Experimental method

X-RAY DIFFRACTION (2.34969764777 Å)