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PDB: 148 件
5WKW
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Crystal structure of apo wild type peptidylglycine alpha-hydroxylating monooxygenase (PHM)
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Peptidyl-glycine alpha-amidating monooxygenase
著者Maheshwari, S, Rudzka, K, Gabelli, S.B, Amzel, L.M.
登録日2017-07-25
公開日2018-07-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Effects of copper occupancy on the conformational landscape of peptidylglycine alpha-hydroxylating monooxygenase.
Commun Biol, 1, 2018
5WM0
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Crystal structure of apo wild type peptidylglycine alpha-hydroxylating monooxygenase (PHM) soaked with peptide (peptide not observed)
分子名称: Peptidyl-glycine alpha-amidating monooxygenase
著者Maheshwari, S, Rudzka, K, Gabelli, S.B, Amzel, L.M.
登録日2017-07-28
公開日2018-07-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Effects of copper occupancy on the conformational landscape of peptidylglycine alpha-hydroxylating monooxygenase.
Commun Biol, 1, 2018
4DWB
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BU of 4dwb by Molmil
Crystal structure of Trypanosoma cruzi farnesyl diphosphate synthase in complex with [2-(n-pentylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+
分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ACETATE ION, Farnesyl pyrophosphate synthase, ...
著者Aripirala, S, Amzel, L.M, Gabelli, S.B.
登録日2012-02-24
公開日2013-01-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.
J.Med.Chem., 55, 2012
4DXJ
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BU of 4dxj by Molmil
Crystal structure of Trypanosome cruzi farnesyl diphosphate synthase in complex with [2-(n-propylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+
分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ACETATE ION, DI(HYDROXYETHYL)ETHER, ...
著者Aripirala, S, Amzel, L.M, Gabelli, S.B.
登録日2012-02-27
公開日2013-01-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.
J.Med.Chem., 55, 2012
5WJI
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BU of 5wji by Molmil
Crystal structure of the F61S mutant of HsNUDT16
分子名称: ACETIC ACID, CHLORIDE ION, SULFATE ION, ...
著者Thirawatananond, P, Gabelli, S.B.
登録日2017-07-23
公開日2018-10-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins.
Sci Rep, 9, 2019
7UUX
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BU of 7uux by Molmil
ATP binds to Cyclic GMP AMP synthase (cGAS) through Mg coordination
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, MAGNESIUM ION, ...
著者Wu, S, Gabelli, S.B, Sohn, J.
登録日2022-04-29
公開日2023-05-03
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Nat Commun, 15, 2024
7V0W
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Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2,5 )pA
分子名称: ADENOSINE MONOPHOSPHATE, Cyclic GMP-AMP synthase, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Wu, S, Gabelli, S.B, Sohn, J.
登録日2022-05-11
公開日2023-05-17
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Nat Commun, 15, 2024
7V0C
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Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
分子名称: Cyclic GMP-AMP synthase, MANGANESE (II) ION, Palindromic DNA18, ...
著者Wu, S, Gabelli, S.B, Sohn, J.
登録日2022-05-10
公開日2023-05-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
To Be Published
7V0R
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Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -ppcpG(2 ,5 )pA
分子名称: Cyclic GMP-AMP synthase, MAGNESIUM ION, Palindromic DNA18, ...
著者Wu, S, Gabelli, S.B, Sohn, J.
登録日2022-05-10
公開日2023-05-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -ppcpG(2 ,5 )pA
To Be Published
6MC9
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BU of 6mc9 by Molmil
Crystal Structure of Human Nav1.4 C-Terminal (1599-1754) domain in complex with calcium-bound calmodulin
分子名称: CALCIUM ION, Calmodulin-1, Sodium channel protein type 4 subunit alpha
著者Yoder, J.B, Gabelli, S.B, Amzel, L.M.
登録日2018-08-30
公開日2019-04-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.
Nat Commun, 10, 2019
4E1E
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BU of 4e1e by Molmil
Crystal structure of Trypanosome cruzi farnesyl diphosphate synthase in complex with [2-(n-hexylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+
分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ...
著者Aripirala, S, Amzel, L.M, Gabelli, S.B.
登録日2012-03-06
公開日2013-01-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.
J.Med.Chem., 55, 2012
8E0P
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BU of 8e0p by Molmil
Crystal structure of mouse APCDD1 in fusion with engineered MBP
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, CHLORIDE ION, ...
著者Hsieh, F.L, Chang, T.H, Gabelli, S.B, Nathans, J.
登録日2022-08-09
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein.
Proc.Natl.Acad.Sci.USA, 120, 2023
6NPZ
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BU of 6npz by Molmil
Crystal structure of Akt1 (aa 123-480) kinase with a bisubstrate
分子名称: GLYCEROL, MANGANESE (II) ION, RAC-alpha serine/threonine-protein kinase, ...
著者Chu, N, Cole, P.A, Gabelli, S.B.
登録日2019-01-18
公開日2019-01-30
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.
Cell, 174, 2018
7UXW
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BU of 7uxw by Molmil
Structure of ATP and GTP bind to Cyclic GMP AMP synthase (cGAS) through Mg coordination
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Wu, S, Gabelli, S.B, Sohn, J.
登録日2022-05-06
公開日2023-05-10
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Nat Commun, 15, 2024
7UYQ
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BU of 7uyq by Molmil
Structure of GTP binds to Cyclic GMP AMP synthase (cGAS) through Mg coordination
分子名称: Cyclic GMP-AMP synthase, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Wu, S, Gabelli, S.B, Sohn, J.
登録日2022-05-07
公開日2023-05-10
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Nat Commun, 15, 2024
7UYZ
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BU of 7uyz by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
分子名称: Cyclic GMP-AMP synthase, GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Wu, S, Gabelli, S.B, Sohn, J.
登録日2022-05-07
公開日2023-05-10
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Nat Commun, 15, 2024
7UZR
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BU of 7uzr by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
分子名称: Cyclic GMP-AMP synthase, MANGANESE (II) ION, Palindromic DNA18, ...
著者Wu, S, Gabelli, S.B, Sohn, J.
登録日2022-05-09
公開日2023-05-10
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Nat Commun, 15, 2024
6UJ8
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BU of 6uj8 by Molmil
Crystal structure of HLA-B*07:02 with wild-type IDH2 peptide
分子名称: Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, HLA class I histocompatibility antigen, ...
著者Miller, M.S, Thirawatananond, P, Gabelli, S.B.
登録日2019-10-02
公開日2021-05-05
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens.
Nat Commun, 12, 2021
6UJ9
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Crystal structure of HLA-B*07:02 with R140Q mutant IDH2 peptide in complex with Fab
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ...
著者Miller, M.S, Thirawatananond, P, Aytenfisu, T.Y, Wright, K, Gabelli, S.B.
登録日2019-10-02
公開日2021-05-05
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens.
Nat Commun, 12, 2021
6UJ7
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BU of 6uj7 by Molmil
Crystal structure of HLA-B*07:02 with R140Q mutant IDH2 peptide
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-7 alpha chain, ...
著者Miller, M.S, Thirawatananond, P, Gabelli, S.B.
登録日2019-10-02
公開日2021-05-05
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens.
Nat Commun, 12, 2021
6W51
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BU of 6w51 by Molmil
Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H
分子名称: Beta-2-microglobulin, Cellular tumor antigen p53 peptide, Immunoglobulin heavy chain H2, ...
著者Wright, K.M, Gabelli, S.B.
登録日2020-03-12
公開日2021-03-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.53 Å)
主引用文献Targeting a neoantigen derived from a common TP53 mutation.
Science, 371, 2021
6BUU
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BU of 6buu by Molmil
Crystal structure of AKT1 (aa 144-480) with a bisubstrate
分子名称: GLY-ARG-PRO-ARG-THR-THR-ZXW-PHE-ALA-GLU, MANGANESE (II) ION, RAC-alpha serine/threonine-protein kinase, ...
著者Chu, N, Gabelli, S.B, Cole, P.A.
登録日2017-12-11
公開日2018-08-22
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.
Cell, 174, 2018
1NQY
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BU of 1nqy by Molmil
The structure of a CoA pyrophosphatase from D. Radiodurans
分子名称: CoA pyrophosphatase (MutT/nudix family protein)
著者Kang, L.W, Gabelli, S.B, Bianchet, M.A, Xu, W.L, Bessman, M.J, Amzel, L.M.
登録日2003-01-23
公開日2003-05-13
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family.
J.Bacteriol., 185, 2003
1NQZ
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The structure of a CoA pyrophosphatase from D. Radiodurans complexed with a magnesium ion
分子名称: CoA pyrophosphatase (MutT/nudix family protein), MAGNESIUM ION
著者Kang, L.W, Gabelli, S.B, Bianchet, M.A, Xu, W.L, Bessman, M.J, Amzel, L.M.
登録日2003-01-23
公開日2003-05-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family.
J.Bacteriol., 185, 2003
6ALV
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BU of 6alv by Molmil
Crystal structure of H107A-peptidylglycine alpha-hydroxylating monooxygenase (PHM) mutant (no CuH bound)
分子名称: AZIDE ION, COPPER (II) ION, GLYCEROL, ...
著者Maheshwari, S, Rudzka, K, Gabelli, S.B, Amzel, L.M.
登録日2017-08-08
公開日2018-07-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Effects of copper occupancy on the conformational landscape of peptidylglycine alpha-hydroxylating monooxygenase.
Commun Biol, 1, 2018

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