8IHH
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![BU of 8ihh by Molmil](/molmil-images/mine/8ihh) | Cryo-EM structure of HCA2-Gi complex with LUF6283 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-butyl-1~{H}-pyrazole-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | Deposit date: | 2023-02-22 | Release date: | 2023-08-30 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun, 14, 2023
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8IHF
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![BU of 8ihf by Molmil](/molmil-images/mine/8ihf) | Cryo-EM structure of HCA2-Gi complex with MK6892 | Descriptor: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | Deposit date: | 2023-02-22 | Release date: | 2023-08-30 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun, 14, 2023
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8IHJ
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![BU of 8ihj by Molmil](/molmil-images/mine/8ihj) | Cryo-EM structure of HCA3-Gi complex with acifran | Descriptor: | (5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | Deposit date: | 2023-02-22 | Release date: | 2023-08-30 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun, 14, 2023
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8IHB
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![BU of 8ihb by Molmil](/molmil-images/mine/8ihb) | Cryo-EM structure of HCA2-Gi complex with GSK256073 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | Deposit date: | 2023-02-22 | Release date: | 2023-09-13 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun, 14, 2023
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2AT9
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![BU of 2at9 by Molmil](/molmil-images/mine/2at9) | STRUCTURE OF BACTERIORHODOPSIN AT 3.0 ANGSTROM BY ELECTRON CRYSTALLOGRAPHY | Descriptor: | 3-[[3-METHYLPHOSPHONO-GLYCEROLYL]PHOSPHONYL]-[1,2-DI[2,6,10,14-TETRAMETHYL-HEXADECAN-16-YL]GLYCEROL, BACTERIORHODOPSIN, RETINAL | Authors: | Mitsuoka, K, Hirai, T, Murata, K, Miyazawa, A, Kidera, A, Kimura, Y, Fujiyoshi, Y. | Deposit date: | 1998-12-17 | Release date: | 1999-04-27 | Last modified: | 2024-06-05 | Method: | ELECTRON CRYSTALLOGRAPHY (3 Å) | Cite: | The structure of bacteriorhodopsin at 3.0 A resolution based on electron crystallography: implication of the charge distribution. J.Mol.Biol., 286, 1999
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4BGN
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![BU of 4bgn by Molmil](/molmil-images/mine/4bgn) | cryo-EM structure of the NavCt voltage-gated sodium channel | Descriptor: | VOLTAGE-GATED SODIUM CHANNEL | Authors: | Tsai, C.J, Tani, K, Irie, K, Hiroaki, Y, Shimomura, T, Mcmillan, D.G, Cook, G.M, Schertler, G, Fujiyoshi, Y, Li, X.D. | Deposit date: | 2013-03-28 | Release date: | 2013-07-10 | Last modified: | 2023-12-20 | Method: | ELECTRON CRYSTALLOGRAPHY (9 Å) | Cite: | Two Alternative Conformations of a Voltage-Gated Sodium Channel. J.Mol.Biol., 425, 2013
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2ZW3
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![BU of 2zw3 by Molmil](/molmil-images/mine/2zw3) | Structure of the connexin-26 gap junction channel at 3.5 angstrom resolution | Descriptor: | Gap junction beta-2 protein | Authors: | Maeda, S, Nakagawa, S, Suga, M, Yamashita, E, Oshima, A, Fujiyoshi, Y, Tsukihara, T. | Deposit date: | 2008-12-01 | Release date: | 2009-04-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of the connexin 26 gap junction channel at 3.5 A resolution Nature, 458, 2009
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2B6P
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![BU of 2b6p by Molmil](/molmil-images/mine/2b6p) | X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state | Descriptor: | Lens fiber major intrinsic protein | Authors: | Gonen, T, Cheng, Y, Sliz, P, Hiroaki, Y, Fujiyoshi, Y, Harrison, S.C, Walz, T. | Deposit date: | 2005-10-03 | Release date: | 2005-12-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature, 438, 2005
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2B6O
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![BU of 2b6o by Molmil](/molmil-images/mine/2b6o) | Electron crystallographic structure of lens Aquaporin-0 (AQP0) (lens MIP) at 1.9A resolution, in a closed pore state | Descriptor: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Lens fiber major intrinsic protein | Authors: | Gonen, T, Cheng, Y, Sliz, P, Hiroaki, Y, Fujiyoshi, Y, Harrison, S.C, Walz, T. | Deposit date: | 2005-10-03 | Release date: | 2005-12-06 | Last modified: | 2023-08-23 | Method: | ELECTRON CRYSTALLOGRAPHY (1.9 Å) | Cite: | Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature, 438, 2005
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3IXZ
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![BU of 3ixz by Molmil](/molmil-images/mine/3ixz) | Pig gastric H+/K+-ATPase complexed with aluminium fluoride | Descriptor: | Potassium-transporting ATPase alpha, Potassium-transporting ATPase subunit beta | Authors: | Abe, K, Tani, K, Nishizawa, T, Fujiyoshi, Y. | Deposit date: | 2009-03-09 | Release date: | 2009-06-23 | Last modified: | 2024-02-21 | Method: | ELECTRON CRYSTALLOGRAPHY (6.5 Å) | Cite: | Inter-subunit interaction of gastric H+,K+-ATPase prevents reverse reaction of the transport cycle Embo J., 28, 2009
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6ACF
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![BU of 6acf by Molmil](/molmil-images/mine/6acf) | structure of leucine dehydrogenase from Geobacillus stearothermophilus by cryo-EM | Descriptor: | Leucine dehydrogenase | Authors: | Yamaguchi, H, Kamegawa, A, Nakata, K, Kashiwagi, T, Mizukoshi, T, Fujiyoshi, Y, Tani, K. | Deposit date: | 2018-07-26 | Release date: | 2018-12-26 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into thermostabilization of leucine dehydrogenase from its atomic structure by cryo-electron microscopy J. Struct. Biol., 205, 2019
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6ACH
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![BU of 6ach by Molmil](/molmil-images/mine/6ach) | Structure of NAD+-bound leucine dehydrogenase from Geobacillus stearothermophilus by cryo-EM | Descriptor: | Leucine dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Yamaguchi, H, Kamegawa, A, Nakata, K, Kashiwagi, T, Mizukoshi, T, Fujiyoshi, Y, Tani, K. | Deposit date: | 2018-07-26 | Release date: | 2018-12-26 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into thermostabilization of leucine dehydrogenase from its atomic structure by cryo-electron microscopy J. Struct. Biol., 205, 2019
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2D57
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![BU of 2d57 by Molmil](/molmil-images/mine/2d57) | Double layered 2D crystal structure of AQUAPORIN-4 (AQP4M23) at 3.2 a resolution by electron crystallography | Descriptor: | Aquaporin-4 | Authors: | Hiroaki, Y, Tani, K, Kamegawa, A, Gyobu, N, Nishikawa, K, Suzuki, H, Walz, T, Sasaki, S, Mitsuoka, K, Kimura, K, Mizoguchi, A, Fujiyoshi, Y. | Deposit date: | 2005-10-29 | Release date: | 2006-01-31 | Last modified: | 2023-11-08 | Method: | ELECTRON CRYSTALLOGRAPHY (3.2 Å) | Cite: | Implications of the Aquaporin-4 Structure on Array Formation and Cell Adhesion J.Mol.Biol., 355, 2005
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5GLH
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![BU of 5glh by Molmil](/molmil-images/mine/5glh) | Human endothelin receptor type-B in complex with ET-1 | Descriptor: | Endothelin Receptor Subtype-B, Peptide from Endothelin-1 | Authors: | Shihoya, W, Nishizawa, T, Okuta, A, Tani, K, Fujiyoshi, Y, Dohmae, N, Nureki, O, Doi, T. | Deposit date: | 2016-07-11 | Release date: | 2016-09-07 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Activation mechanism of endothelin ETB receptor by endothelin-1. Nature, 537, 2016
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5H1R
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![BU of 5h1r by Molmil](/molmil-images/mine/5h1r) | |
5GLI
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![BU of 5gli by Molmil](/molmil-images/mine/5gli) | Human endothelin receptor type-B in the ligand-free form | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Endothelin Receptor Subtype-B, OLEIC ACID, ... | Authors: | Shihoya, W, Nishizawa, T, Okuta, A, Tani, K, Fujiyoshi, Y, Dohmae, N, Nureki, O, Doi, T. | Deposit date: | 2016-07-11 | Release date: | 2016-09-07 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Activation mechanism of endothelin ETB receptor by endothelin-1. Nature, 537, 2016
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5H1Q
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![BU of 5h1q by Molmil](/molmil-images/mine/5h1q) | |
4AQ5
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![BU of 4aq5 by Molmil](/molmil-images/mine/4aq5) | |
4AQ9
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![BU of 4aq9 by Molmil](/molmil-images/mine/4aq9) | |
7F8J
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![BU of 7f8j by Molmil](/molmil-images/mine/7f8j) | Cryo-EM structure of human pannexin-1 in a nanodisc | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Pannexin-1 | Authors: | Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2021-07-02 | Release date: | 2022-01-26 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci.Signal., 15, 2022
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7F8O
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![BU of 7f8o by Molmil](/molmil-images/mine/7f8o) | Cryo-EM structure of the C-terminal deletion mutant of human PANX1 in a nanodisc | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Pannexin-1 | Authors: | Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2021-07-02 | Release date: | 2022-01-26 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci.Signal., 15, 2022
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7F8N
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![BU of 7f8n by Molmil](/molmil-images/mine/7f8n) | Human pannexin-1 showing a conformational change in the N-terminal domain and blocked pore | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Pannexin-1 | Authors: | Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2021-07-02 | Release date: | 2022-01-26 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci.Signal., 15, 2022
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8GCL
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![BU of 8gcl by Molmil](/molmil-images/mine/8gcl) | Cryo-EM structure of hAQP2 in DDM | Descriptor: | Aquaporin-2 | Authors: | Kamegawa, A, Suzuki, S, Nishikawa, K, Numoto, N, Suzuki, H, Fujiyoshi, Y. | Deposit date: | 2023-03-02 | Release date: | 2023-06-21 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structural analysis of the water channel AQP2 by single-particle cryo-EM. J.Struct.Biol., 215, 2023
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8HUJ
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![BU of 8huj by Molmil](/molmil-images/mine/8huj) | Cryo-EM structure of the J-K-St region of EMCV IRES in complex with eIF4G-HEAT1 and eIF4A | Descriptor: | Eukaryotic initiation factor 4A-I, Eukaryotic translation initiation factor 4 gamma 1, IRES RNA (J-K-St), ... | Authors: | Suzuki, H, Fujiyoshi, Y, Imai, S, Shimada, I. | Deposit date: | 2022-12-24 | Release date: | 2023-08-02 | Last modified: | 2023-09-13 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Dynamically regulated two-site interaction of viral RNA to capture host translation initiation factor. Nat Commun, 14, 2023
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6KFF
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![BU of 6kff by Molmil](/molmil-images/mine/6kff) | Undocked INX-6 hemichannel in a nanodisc | Descriptor: | Innexin-6 | Authors: | Burendei, B, Shinozaki, R, Watanabe, M, Terada, T, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2019-07-07 | Release date: | 2020-02-12 | Last modified: | 2020-03-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids. Sci Adv, 6, 2020
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