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PDB: 94 件
1II6
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Crystal Structure of the Mitotic Kinesin Eg5 in Complex with Mg-ADP.
分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-RELATED MOTOR PROTEIN Eg5, MAGNESIUM ION, ...
著者Turner, J, Anderson, R, Guo, J, Beraud, C, Sakowicz, R, Fletterick, R.
登録日2001-04-20
公開日2001-07-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.
J.Biol.Chem., 276, 2001
1T65
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Crystal structure of the androgen receptor ligand binding domain with DHT and a peptide derived form its physiological coactivator GRIP1 NR box 2 bound in a non-helical conformation
分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, Nuclear receptor coactivator 2
著者Estebanez-Perpina, E, Moore, J.M.R, Mar, E, Nguyen, P, Delgado-Rodrigues, E, Baxter, J.D, Webb, P, Fletterick, R.J, Guy, R.K.
登録日2004-05-05
公開日2005-01-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor.
J.Biol.Chem., 280, 2005
1NQ1
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BU of 1nq1 by Molmil
TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD
分子名称: ARSENIC, Thyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID
著者Huber, B.R, Desclozeaux, M, West, B.L, Cunha-Lima, S.T, Nguyen, H.T, Baxter, J.D, Ingraham, H.A, Fletterick, R.J.
登録日2003-01-20
公開日2003-04-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain
Mol.Endocrinol., 17, 2003
1FI8
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BU of 1fi8 by Molmil
RAT GRANZYME B [N66Q] COMPLEXED TO ECOTIN [81-84 IEPD]
分子名称: ECOTIN, NATURAL KILLER CELL PROTEASE 1
著者Waugh, S.M, Harris, J.L, Fletterick, R.J, Craik, C.S.
登録日2000-08-03
公開日2000-09-13
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity
Nat.Struct.Biol., 7, 2000
1SLW
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BU of 1slw by Molmil
RAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN; NICKEL-BOUND
分子名称: ACETATE ION, ANIONIC TRYPSIN, CALCIUM ION, ...
著者Brinen, L.S, Fletterick, R.J.
登録日1996-02-07
公開日1996-07-11
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Biochemistry, 35, 1996
2PKL
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BU of 2pkl by Molmil
Androgen receptor LBD with small molecule
分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, ARA70 peptide, Androgen receptor, ...
著者Estebanez-Perpina, E, Arnold, A.A, Baxter, J.D, Guy, K.R, Webb, P, Fletterick, R.J.
登録日2007-04-17
公開日2007-09-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献A surface on the androgen receptor that allosterically regulates coactivator binding.
Proc.Natl.Acad.Sci.Usa, 104, 2007
1SLX
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BU of 1slx by Molmil
RAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN; ZINC-BOUND
分子名称: ACETATE ION, ANIONIC TRYPSIN, CALCIUM ION, ...
著者Brinen, L.S, Fletterick, R.J.
登録日1996-02-07
公開日1996-07-11
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Biochemistry, 35, 1996
1SLU
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BU of 1slu by Molmil
RAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN
分子名称: ACETATE ION, ANIONIC TRYPSIN, CALCIUM ION, ...
著者Brinen, L.S, Fletterick, R.J.
登録日1996-02-07
公開日1996-07-11
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Biochemistry, 35, 1996
1SLV
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BU of 1slv by Molmil
RAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN; COPPER-BOUND
分子名称: ACETATE ION, ANIONIC TRYPSIN, CALCIUM ION, ...
著者Brinen, L.S, Fletterick, R.J.
登録日1996-02-07
公開日1996-07-11
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Biochemistry, 35, 1996
1HGX
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BU of 1hgx by Molmil
HYPOXANTHINE-GUANINE-XANTHINE PHOSPHORIBOSYLTRANSFERASE (HGXPRTASE)
分子名称: GUANOSINE-5'-MONOPHOSPHATE, HYPOXANTHINE-GUANINE-XANTHINE PHOSPHORIBOSYLTRANSFERASE, SULFATE ION
著者Somoza, J.R, Wang, C.C, Fletterick, R.J.
登録日1996-03-12
公開日1996-08-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus.
Biochemistry, 35, 1996
1NUO
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BU of 1nuo by Molmil
Two RTH Mutants with Impaired Hormone Binding
分子名称: Thyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID
著者Huber, B.R, Sandler, B, West, B.L, Cunha-Lima, S.T, Nguyen, H.T, Apriletti, J.W, Baxter, J.D, Fletterick, R.J.
登録日2003-01-31
公開日2003-04-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Two resistance to thyroid hormone mutants with impaired hormone binding
Mol.Endocrinol., 17, 2003
1TC1
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BU of 1tc1 by Molmil
A 1.4 ANGSTROM CRYSTAL STRUCTURE FOR THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE OF TRYPANOSOMA CRUZI
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FORMYCIN B, PROTEIN (HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE)
著者Focia, P.J, Craig III, S.P, Nieves-Alicea, R, Fletterick, R.J, Eakin, A.E.
登録日1998-09-30
公開日1999-10-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi.
Biochemistry, 37, 1998
1L5Q
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Human liver glycogen phosphorylase a complexed with caffeine, N-Acetyl-beta-D-glucopyranosylamine, and CP-403700
分子名称: CAFFEINE, Glycogen phosphorylase, liver form, ...
著者Ekstrom, J.L, Pauly, T.A, Carty, M.D, Soeller, W.C, Culp, J, Danley, D.E, Hoover, D.J, Treadway, J.L, Gibbs, E.M, Fletterick, R.J, Day, Y.S.N, Myszka, D.G, Rath, V.L.
登録日2002-03-07
公開日2002-12-04
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
1BF6
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BU of 1bf6 by Molmil
PHOSPHOTRIESTERASE HOMOLOGY PROTEIN FROM ESCHERICHIA COLI
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, PHOSPHOTRIESTERASE HOMOLOGY PROTEIN, ...
著者Buchbinder, J.L, Stephenson, R.C, Scanlan, T.S, Fletterick, R.J.
登録日1998-05-27
公開日1999-06-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Biochemical characterization and crystallographic structure of an Escherichia coli protein from the phosphotriesterase gene family.
Biochemistry, 37, 1998
1L5R
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BU of 1l5r by Molmil
Human liver glycogen phosphorylase a complexed with riboflavin, N-Acetyl-beta-D-Glucopyranosylamine and CP-403,700
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, N-acetyl-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE, ...
著者Ekstrom, J.L, Pauly, T.A, Carty, M.D, Soeller, W.C, Culp, J, Danley, D.E, Hoover, D.J, Treadway, J.L, Gibbs, E.M, Fletterick, R.J, Day, Y.S.N, Myszka, D.G, Rath, V.L.
登録日2002-03-07
公開日2002-12-04
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
1L7X
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Human liver glycogen phosphorylase b complexed with caffeine, N-acetyl-beta-D-glucopyranosylamine, and CP-403,700
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, CAFFEINE, Glycogen phosphorylase, ...
著者Ekstrom, J.L, Pauly, T.A, Carty, M.D, Soeller, W.C, Culp, J, Danley, D.E, Hoover, D.J, Treadway, J.L, Gibbs, E.M, Fletterick, R.J, Day, Y.S.N, Myszka, D.G, Rath, V.L.
登録日2002-03-18
公開日2002-12-04
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
1L5S
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BU of 1l5s by Molmil
Human liver glycogen phosphorylase complexed with uric acid, N-Acetyl-beta-D-glucopyranosylamine, and CP-403,700
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Glycogen phosphorylase, liver form, ...
著者Ekstrom, J.L, Pauly, T.A, Carty, M.D, Soeller, W.C, Culp, J, Danley, D.E, Hoover, D.J, Treadway, J.L, Gibbs, E.M, Fletterick, R.J, Day, Y.S.N, Myszka, D.G, Rath, V.L.
登録日2002-03-07
公開日2002-12-04
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
2PIN
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BU of 2pin by Molmil
Thyroid receptor beta in complex with inhibitor
分子名称: 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE, SULFATE ION, Thyroid hormone receptor beta-1, ...
著者Estebanez-Perpina, E, Jouravel, N, Baxter, J.D, Guy, L.R, Webb, P, Fletterick, R.J.
登録日2007-04-13
公開日2008-02-26
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor.
Mol.Endocrinol., 21, 2007
1NT3
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BU of 1nt3 by Molmil
HUMAN NEUROTROPHIN-3
分子名称: PROTEIN (NEUROTROPHIN-3)
著者Butte, M.J, Hwang, P.K, Mobley, W.C, Fletterick, R.J.
登録日1999-05-17
公開日1999-06-06
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors.
Biochemistry, 37, 1998
1EWL
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BU of 1ewl by Molmil
CRYSTAL STRUCTURE OF CRUZAIN BOUND TO WRR-99
分子名称: CRUZAIN, N-[3-CARBOXY-2-HYDROXY-PROPIONYL]-D-HOMOPHENYLALANYL-AMINO-2-METHYLBUTANE
著者Brinen, L.S, Gillmor, S.A, Fletterick, R.J.
登録日2000-04-26
公開日2003-06-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Cruzain bound to WRR-99
To be Published
1EWM
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THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-112
分子名称: CRUZAIN, N-[3-CARBOXY-2-HYDROXY-PROPIONYL]-L-HOMOPHENYLALANYL-AMINO-2-METHYLBUTANE
著者Brinen, L.S, Gillmor, S.A, Fletterick, R.J.
登録日2000-04-26
公開日2003-06-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Cruzain bound to WRR-112
To be Published
1EWO
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BU of 1ewo by Molmil
THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204
分子名称: CRUZAIN, N-[N'-BENZYLOXYCARBONYL-PHENYLALANINYL]-3-AMINO-5-PHENYL-PENTANE-1-SULFONIC ACID PHENYL ESTER
著者Brinen, L.S, Gillmor, S.A, Fletterick, R.J.
登録日2000-04-26
公開日2003-06-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of Cruzain bound to WRR-204
To be Published
1A0Q
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BU of 1a0q by Molmil
29G11 COMPLEXED WITH PHENYL [1-(1-N-SUCCINYLAMINO)PENTYL] PHOSPHONATE
分子名称: 29G11 FAB (HEAVY CHAIN), 29G11 FAB (LIGHT CHAIN), PHENYL[1-(N-SUCCINYLAMINO)PENTYL]PHOSPHONATE, ...
著者Buchbinder, J.L, Stephenson, R.C, Scanlan, T.S, Fletterick, R.J.
登録日1997-12-05
公開日1999-03-02
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A comparison of the crystallographic structures of two catalytic antibodies with esterase activity.
J.Mol.Biol., 282, 1998
1BRC
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BU of 1brc by Molmil
RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN
分子名称: AMYLOID BETA-PROTEIN PRECURSOR INHIBITOR DOMAIN (APPI), TRYPSIN
著者Perona, J.J, Fletterick, R.J.
登録日1992-12-17
公開日1994-05-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Relocating a negative charge in the binding pocket of trypsin.
J.Mol.Biol., 230, 1993
1P0S
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BU of 1p0s by Molmil
Crystal Structure of Blood Coagulation Factor Xa in Complex with Ecotin M84R
分子名称: Coagulation factor X precursor, Ecotin precursor, MAGNESIUM ION, ...
著者Wang, S.X, Hur, E, Sousa, C.A, Brinen, L, Slivka, E.J, Fletterick, R.J.
登録日2003-04-10
公開日2003-08-26
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The Extended Interactions and Gla Domain of Blood Coagulation Factor Xa
Biochemistry, 42, 2003

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