1NUO
Two RTH Mutants with Impaired Hormone Binding
Summary for 1NUO
Entry DOI | 10.2210/pdb1nuo/pdb |
Descriptor | Thyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID (2 entities in total) |
Functional Keywords | alpha helix, nuclear receptor, ligand binding domain, hormone-growth factor receptor complex, hormone/growth factor receptor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P10828 |
Total number of polymer chains | 1 |
Total formula weight | 30131.06 |
Authors | Huber, B.R.,Sandler, B.,West, B.L.,Cunha-Lima, S.T.,Nguyen, H.T.,Apriletti, J.W.,Baxter, J.D.,Fletterick, R.J. (deposition date: 2003-01-31, release date: 2003-04-15, Last modification date: 2024-04-03) |
Primary citation | Huber, B.R.,Sandler, B.,West, B.L.,Cunha-Lima, S.T.,Nguyen, H.T.,Apriletti, J.W.,Baxter, J.D.,Fletterick, R.J. Two resistance to thyroid hormone mutants with impaired hormone binding Mol.Endocrinol., 17:643-652, 2003 Cited by PubMed: 12554782DOI: 10.1210/me.2002-0095 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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