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PDB: 17 results

7OA4
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BU of 7oa4 by Molmil
Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound L-742,001
Descriptor: (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, FORMIC ACID, MANGANESE (II) ION, ...
Authors:Feracci, M, Hernandez, S, Vincentelli, R, Ferron, F, Reguera, J, Canard, B, Alvarez, K.
Deposit date:2021-04-19
Release date:2022-08-03
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options.
Iucrj, 11, 2024
6R9H
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BU of 6r9h by Molmil
Crystal structure of the PDZ tandem of syntenin in complex with fragment C58
Descriptor: (2~{S})-2-[2-(4-chlorophenyl)sulfanylethanoylamino]-3-methyl-butanoic acid, ACETATE ION, PHOSPHATE ION, ...
Authors:Feracci, M, Barral, K.
Deposit date:2019-04-03
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loadifing with syndecan and EpCAM cargo.
J Extracell Vesicles, 10, 2020
6RLC
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BU of 6rlc by Molmil
Crystal structure of the PDZ tandem of syntenin in complex with fragment F13
Descriptor: (2~{S})-2-[3-(4-chlorophenyl)sulfanylpropanoylamino]-3-methyl-butanoic acid, ACETATE ION, Syntenin-1
Authors:Feracci, M, Barral, K.
Deposit date:2019-05-02
Release date:2021-02-03
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loadifing with syndecan and EpCAM cargo.
J Extracell Vesicles, 10, 2020
7PLR
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BU of 7plr by Molmil
Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound Baloxavir
Descriptor: Baloxavir acid, FORMIC ACID, GLYCEROL, ...
Authors:Feracci, M, Hernandez, S, Vincentelli, R, Ferron, F, Reguera, J, Canard, B, Alvarez, K.
Deposit date:2021-09-01
Release date:2022-09-14
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options.
Iucrj, 11, 2024
8PIE
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BU of 8pie by Molmil
Crystal structure of the human nucleoside diphosphate kinase B domain in complex with the product AT-8500 formed by catalysis of compound AT-9010
Descriptor: GLYCEROL, Nucleoside diphosphate kinase B, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate
Authors:Feracci, M, Chazot, A, Ferron, F, Alvarez, K, Canard, B.
Deposit date:2023-06-21
Release date:2024-07-31
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution.
Plos Biol., 22, 2024
8PYW
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BU of 8pyw by Molmil
Crystal structure of the human Nucleoside-diphosphate kinase B domain bound to compound diphosphate form of AT-9052-Sp.
Descriptor: GLYCEROL, Nucleoside diphosphate kinase B, [[(2R,3R,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-sulfanyl-phosphoryl] dihydrogen phosphate
Authors:Feracci, M, Chazot, A.
Deposit date:2023-07-26
Release date:2023-12-27
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.553 Å)
Cite:An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex.
Nucleic Acids Res., 52, 2024
8AAK
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BU of 8aak by Molmil
Crystal structure of the PDZ tandem of syntenin in complex with compound 29
Descriptor: (2~{S})-2-[[(2~{S})-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)-3-phenyl-propanoyl]amino]propanoic acid, GLYCEROL, Syntenin-1
Authors:Feracci, M, Barral, K.
Deposit date:2022-07-01
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.554 Å)
Cite:Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
8AAP
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BU of 8aap by Molmil
Crystal structure of the PDZ tandem of syntenin in complex with compound SYNTi
Descriptor: (2S)-2-[[(2S)-2-(6-bromanyl-3-oxidanylidene-1H-isoindol-2-yl)-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]propanoyl]amino]propanoic acid, Syntenin-1
Authors:Feracci, M, Barral, K.
Deposit date:2022-07-01
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.174 Å)
Cite:Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
8AAO
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BU of 8aao by Molmil
Crystal structure of the PDZ tandem of syntenin in complex with compound 95
Descriptor: (2~{S})-2-[[(2~{S})-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanoyl]amino]propanoic acid, Syntenin-1
Authors:Feracci, M, Barral, K.
Deposit date:2022-07-01
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.469 Å)
Cite:Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
8AAI
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BU of 8aai by Molmil
Crystal structure of the PDZ tandem of syntenin in complex with fragment E5
Descriptor: (2~{S})-2-[[(2~{S})-3-methyl-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)butanoyl]amino]propanoic acid, Syntenin-1
Authors:Feracci, M, Barral, K.
Deposit date:2022-07-01
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
7ED5
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BU of 7ed5 by Molmil
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Shannon, A, Fattorini, V, Sama, B, Selisko, B, Feracci, M, Falcou, C, Gauffre, P, El Kazzi, P, Delpal, A, Decroly, E, Alvarez, K, Eydoux, C, Guillemot, J.-C, Moussa, A, Good, S, Colla, P, Lin, K, Sommadossi, J.-P, Zhu, Y.X, Yan, X.D, Shi, H, Ferron, F, Canard, B.
Deposit date:2021-03-15
Release date:2022-02-16
Last modified:2024-04-10
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
Nat Commun, 13, 2022
2LKQ
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BU of 2lkq by Molmil
NMR structure of the lambda 5 22-45 peptide
Descriptor: Immunoglobulin lambda-like polypeptide 1
Authors:Elantak, L, Espeli, M, Boned, A, Bornet, O, Breton, C, Feracci, M, Roche, P, Guerlesquin, F, Schiff, C.
Deposit date:2011-10-19
Release date:2012-10-24
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation.
J.Biol.Chem., 287, 2012
5ELR
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BU of 5elr by Molmil
Structure of the KH-QUA2 domain of T-STAR in complex with AAUAAU RNA
Descriptor: KH domain-containing, RNA-binding, signal transduction-associated protein 3, ...
Authors:Dominguez, C, Feracci, M.
Deposit date:2015-11-05
Release date:2016-01-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Nat Commun, 7, 2016
5EL3
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BU of 5el3 by Molmil
Structure of the KH domain of T-STAR
Descriptor: KH domain-containing, RNA-binding, signal transduction-associated protein 3, ...
Authors:Dominguez, C, Feracci, M.
Deposit date:2015-11-04
Release date:2016-01-13
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Nat Commun, 7, 2016
5ELT
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BU of 5elt by Molmil
Structure of the QUA1-KH domain of T-STAR in complex with UAAU RNA
Descriptor: KH domain-containing, RNA-binding, signal transduction-associated protein 3, ...
Authors:Dominguez, C, Feracci, M.
Deposit date:2015-11-05
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Nat Commun, 7, 2016
5EMO
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BU of 5emo by Molmil
Structure of the star domain of T-STAR in complex with AUUAAA RNA
Descriptor: KH domain-containing, RNA-binding, signal transduction-associated protein 3, ...
Authors:Dominguez, C, Feracci, M.
Deposit date:2015-11-06
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Nat Commun, 7, 2016
5ELS
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BU of 5els by Molmil
Structure of the KH domain of T-STAR in complex with AAAUAA RNA
Descriptor: KH domain-containing, RNA-binding, signal transduction-associated protein 3, ...
Authors:Dominguez, C, Feracci, M.
Deposit date:2015-11-05
Release date:2016-01-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.873 Å)
Cite:Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Nat Commun, 7, 2016

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PDB entries from 2024-11-20

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