6R9H

Crystal structure of the PDZ tandem of syntenin in complex with fragment C58

Summary for 6R9H

Entry DOI	10.2210/pdb6r9h/pdb
Descriptor	Syntenin-1, PHOSPHATE ION, (2~{S})-2-[2-(4-chlorophenyl)sulfanylethanoylamino]-3-methyl-butanoic acid, ... (5 entities in total)
Functional Keywords	signaling protein cell adhesion pdz domain syntenin syndecan drug design, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	73235.35
Authors	Feracci, M.,Barral, K. (deposition date: 2019-04-03, release date: 2021-02-03, Last modification date: 2024-01-24)
Primary citation	Leblanc, R.,Kashyap, R.,Barral, K.,Egea-Jimenez, A.L.,Kovalskyy, D.,Feracci, M.,Garcia, M.,Derviaux, C.,Betzi, S.,Ghossoub, R.,Platonov, M.,Roche, P.,Morelli, X.,Hoffer, L.,Zimmermann, P. Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loadifing with syndecan and EpCAM cargo. J Extracell Vesicles, 10:e12039-e12039, 2020 Cited by PubMed: 33343836 DOI: 10.1002/jev2.12039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation