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PDB: 88 件
5ETJ
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BU of 5etj by Molmil
Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human complexed with DADMe-ImmG and phosphate
分子名称: 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Cameron, S.A, Suarez, J, Schramm, V.L, Almo, S.C.
登録日2015-11-17
公開日2016-09-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics.
J.Am.Chem.Soc., 138, 2016
4X24
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BU of 4x24 by Molmil
Crystal structure of Vibrio cholerae 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with methylthio-DADMe-Immucillin-A
分子名称: (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, TRIETHYLENE GLYCOL
著者Cameron, S.A, Thomas, K, Almo, S.C, Schramm, V.L.
登録日2014-11-25
公開日2015-08-19
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.
Biochemistry, 54, 2015
4YML
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BU of 4yml by Molmil
Crystal structure of Escherichia coli 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3S,4R)-methylthio-DADMe-Immucillin-A
分子名称: (3S,4R)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, PHOSPHATE ION
著者Cameron, S.A, Thomas, K, Almo, S.C, Schramm, V.L.
登録日2015-03-06
公開日2015-08-26
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Tight binding enantiomers of pre-clinical drug candidates.
Bioorg.Med.Chem., 23, 2015
6GVC
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BU of 6gvc by Molmil
Structure of ArhGAP12 bound to G-Actin
分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
著者Mouilleron, S, Treisman, R, Diring, J.
登録日2018-06-20
公開日2019-03-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability.
Nat.Cell Biol., 21, 2019
5TC5
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BU of 5tc5 by Molmil
Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with butylthio-DADMe-Immucillin-A and chloride
分子名称: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol, CHLORIDE ION, S-methyl-5'-thioadenosine phosphorylase
著者Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C.
登録日2016-09-14
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献TBA
To be published
6HOJ
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BU of 6hoj by Molmil
Structure of Beclin1 LIR motif bound to GABARAP
分子名称: 1,2-ETHANEDIOL, Beclin-1,Gamma-aminobutyric acid receptor-associated protein, SULFATE ION
著者Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
登録日2018-09-17
公開日2019-02-27
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
6HYO
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BU of 6hyo by Molmil
Structure of ULK1 LIR motif bound to GABARAP
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Mouilleron, S, Wirth, M, Zhang, W, O'Reilly, N, Tooze, S, Johansen, T, Razi, M, Nyoni, L, Joshi, D.
登録日2018-10-22
公開日2019-05-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.07 Å)
主引用文献Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Nat Commun, 10, 2019
6HYN
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BU of 6hyn by Molmil
Structure of ATG13 LIR motif bound to GABARAP
分子名称: Autophagy-related protein 13,Gamma-aminobutyric acid receptor-associated protein
著者Mouilleron, S, Wirth, M, Zhang, W, O'Reilly, N, Tooze, S, Johansen, T, Razi, M, Nyoni, L, Joshi, D.
登録日2018-10-22
公開日2019-05-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.14 Å)
主引用文献Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Nat Commun, 10, 2019
6HOI
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BU of 6hoi by Molmil
Structure of Beclin1 LIR motif bound to GABARAPL1
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Beclin-1, ...
著者Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
登録日2018-09-17
公開日2019-02-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.14 Å)
主引用文献Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
6HYM
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BU of 6hym by Molmil
Structure of PCM1 LIR motif bound to GABARAP
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Pericentriolar material 1 protein,Gamma-aminobutyric acid receptor-associated protein
著者Mouilleron, S, Wirth, M, Zhang, W, O'Reilly, N, Tooze, S, Johansen, T, Razi, M, Nyoni, L, Joshi, D.
登録日2018-10-22
公開日2019-05-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Nat Commun, 10, 2019
6HOH
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BU of 6hoh by Molmil
Structure of VPS34 LIR motif (S249E) bound to GABARAP
分子名称: Phosphatidylinositol 3-kinase catalytic subunit type 3,Gamma-aminobutyric acid receptor-associated protein, TRIETHYLENE GLYCOL
著者Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
登録日2018-09-17
公開日2019-02-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
5TC8
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BU of 5tc8 by Molmil
Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with methylthio-DADMe-Immucillin-A
分子名称: (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C.
登録日2016-09-14
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献TBA
To be published
5TC6
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BU of 5tc6 by Molmil
Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with propylthio-immucillin-A
分子名称: (2S,3S,4R,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(propylsulfanyl)methyl]pyrrolidine-3,4-diol, CHLORIDE ION, GLYCEROL, ...
著者Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C.
登録日2016-09-14
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献TBA
To be published
5TC7
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BU of 5tc7 by Molmil
Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 5'-methylthiotubercidin at 1.75 angstrom
分子名称: 2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-METHYLSULFANYLMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, CHLORIDE ION, PHOSPHATE ION, ...
著者Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C.
登録日2016-09-14
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献TBA
To be published
6HYL
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BU of 6hyl by Molmil
Structure of PCM1 LIR motif bound to GABARAP
分子名称: Pericentriolar material 1 protein,Gamma-aminobutyric acid receptor-associated protein
著者Mouilleron, S, Wirth, M, Zhang, W, O'Reilly, N, Tooze, S, Johansen, T, Razi, M, Nyoni, L, Joshi, D.
登録日2018-10-22
公開日2019-05-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.559 Å)
主引用文献Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Nat Commun, 10, 2019
6HOL
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BU of 6hol by Molmil
Structure of ATG14 LIR motif bound to GABARAPL1
分子名称: Beclin 1-associated autophagy-related key regulator, GLYCEROL, Gamma-aminobutyric acid receptor-associated protein-like 1, ...
著者Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
登録日2018-09-17
公開日2019-02-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
6HOG
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BU of 6hog by Molmil
Structure of VPS34 LIR motif bound to GABARAP
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Phosphatidylinositol 3-kinase catalytic subunit type 3,Gamma-aminobutyric acid receptor-associated protein, ...
著者Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
登録日2018-09-17
公開日2019-02-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
6HOK
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BU of 6hok by Molmil
Structure of Beclin1 LIR (S96E) motif bound to GABARAP
分子名称: 1,2-ETHANEDIOL, Beclin-1,Gamma-aminobutyric acid receptor-associated protein
著者Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
登録日2018-09-17
公開日2019-02-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
6G86
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BU of 6g86 by Molmil
Structure of Cdc14 bound to SIC1 PxL motif
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, ...
著者Mouilleron, S, Kataria, M, Uhlmann, F.
登録日2018-04-07
公開日2018-10-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase.
Nat. Struct. Mol. Biol., 25, 2018
2YJE
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BU of 2yje by Molmil
Oligomeric assembly of actin bound to MRTF-A
分子名称: ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Mouilleron, S, Langer, C.A, Guettler, S, McDonald, N.Q, Treisman, R.
登録日2011-05-19
公開日2011-07-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.
Sci Signal, 4, 2011
2YJF
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BU of 2yjf by Molmil
Oligomeric assembly of actin bound to MRTF-A
分子名称: ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Mouilleron, S, Langer, C.A, Guettler, S, McDonald, N.Q, Treisman, R.
登録日2011-05-19
公開日2011-07-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.
Sci Signal, 4, 2011
6G84
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BU of 6g84 by Molmil
Structure of Cdc14 bound to CBK1 PxL motif
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CBK1, ...
著者Mouilleron, S, Kataria, M, Uhlmann, F.
登録日2018-04-07
公開日2018-10-10
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase.
Nat. Struct. Mol. Biol., 25, 2018
6G85
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BU of 6g85 by Molmil
Structure of Cdc14 bound to CBK1 PxL motif
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CBK1, ...
著者Mouilleron, S, Kataria, M, Uhlmann, F.
登録日2018-04-07
公開日2018-10-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.528 Å)
主引用文献A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase.
Nat. Struct. Mol. Biol., 25, 2018
3OOJ
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BU of 3ooj by Molmil
C1A mutant of E. coli GlmS in complex with glucose-6P and glutamate
分子名称: 6-O-phosphono-alpha-D-glucopyranose, GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, ...
著者Mouilleron, S, Golinelli-Pimpaneau, B.
登録日2010-08-31
公開日2011-10-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for morpheein-type allosteric regulation of Escherichia coli glucosamine-6-phosphate synthase: equilibrium between inactive hexamer and active dimer.
J.Biol.Chem., 287, 2012
2V6U
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BU of 2v6u by Molmil
High resolution crystal structure of pterin-4a-carbinolamine dehydratase from Toxoplasma gondii
分子名称: PTERIN-4A-CARBINOLAMINE DEHYDRATASE, SODIUM ION
著者Cameron, S, Goldie, S.P, Hunter, W.N.
登録日2007-07-20
公開日2008-07-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structures of Toxoplasma Gondii Pterin-4A-Carbinolamine Dehydratase and Comparisons with Mammalian and Parasite Orthologues.
Mol.Biochem.Parasitol., 158, 2008

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