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4X24

Crystal structure of Vibrio cholerae 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with methylthio-DADMe-Immucillin-A

Summary for 4X24
Entry DOI10.2210/pdb4x24/pdb
Related3DP9 4WKB
Descriptor5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL, TRIETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywordshydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Total number of polymer chains2
Total formula weight53068.59
Authors
Cameron, S.A.,Thomas, K.,Almo, S.C.,Schramm, V.L. (deposition date: 2014-11-25, release date: 2015-08-19, Last modification date: 2023-09-27)
Primary citationThomas, K.,Cameron, S.A.,Almo, S.C.,Burgos, E.S.,Gulab, S.A.,Schramm, V.L.
Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.
Biochemistry, 54:2520-2529, 2015
Cited by
PubMed: 25806409
DOI: 10.1021/bi501487w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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