4X24
Crystal structure of Vibrio cholerae 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with methylthio-DADMe-Immucillin-A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | polymer | 244 | 26165.8 | 2 | UniProt (A5F5R2) Pfam (PF01048) In PDB | Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) | MTAN,5'-methylthioadenosine nucleosidase,MTA nucleosidase,S-adenosylhomocysteine nucleosidase,SRH nucleosidase |
2 | A, B | (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL | non-polymer | 293.4 | 2 | Chemie (TDI) | |||
3 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
4 | water | water | 18.0 | 360 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 231 (UniProt: A5F5R2)
PDB | External Database | Details |
---|---|---|
Pro 113 | Ala 113 | engineered mutation |
Ile 153 | Val 153 | engineered mutation |
Gly 158 | Arg 158 | engineered mutation |
Glu 232 | - | expression tag |
Asn 233 | - | expression tag |
Leu 234 | - | expression tag |
Tyr 235 | - | expression tag |
Phe 236 | - | expression tag |
Gln 237 | - | expression tag |
Gly 238 | - | expression tag |
His 239 | - | expression tag |
His 240 | - | expression tag |
His 241 | - | expression tag |
His 242 | - | expression tag |
His 243 | - | expression tag |
His 244 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 52331.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 736.9 | |
All* | Total formula weight | 53068.6 |