6NWD
 
 | | X-ray Crystallographic structure of Gloeobacter rhodopsin | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, DECANE, DODECANE, ... | | 著者 | Ernst, O.P, Morizumi, T, Ou, W.L. | | 登録日 | 2019-02-06 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | X-ray Crystallographic Structure and Oligomerization of Gloeobacter Rhodopsin.
Sci Rep, 9, 2019
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4ZWJ
 | | Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser | | 分子名称: | Chimera protein of human Rhodopsin, mouse S-arrestin, and T4 Endolysin | | 著者 | Kang, Y, Zhou, X.E, Gao, X, He, Y, Liu, W, Ishchenko, A, Barty, A, White, T.A, Yefanov, O, Han, G.W, Xu, Q, de Waal, P.W, Ke, J, Tan, M.H.E, Zhang, C, Moeller, A, West, G.M, Pascal, B, Eps, N.V, Caro, L.N, Vishnivetskiy, S.A, Lee, R.J, Suino-Powell, K.M, Gu, X, Pal, K, Ma, J, Zhi, X, Boutet, S, Williams, G.J, Messerschmidt, M, Gati, C, Zatsepin, N.A, Wang, D, James, D, Basu, S, Roy-Chowdhury, S, Conrad, C, Coe, J, Liu, H, Lisova, S, Kupitz, C, Grotjohann, I, Fromme, R, Jiang, Y, Tan, M, Yang, H, Li, J, Wang, M, Zheng, Z, Li, D, Howe, N, Zhao, Y, Standfuss, J, Diederichs, K, Dong, Y, Potter, C.S, Carragher, B, Caffrey, M, Jiang, H, Chapman, H.N, Spence, J.C.H, Fromme, P, Weierstall, U, Ernst, O.P, Katritch, V, Gurevich, V.V, Griffin, P.R, Hubbell, W.L, Stevens, R.C, Cherezov, V, Melcher, K, Xu, H.E, GPCR Network (GPCR) | | 登録日 | 2015-05-19 | | 公開日 | 2015-07-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.302 Å) | | 主引用文献 | Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.
Nature, 523, 2015
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6XL3
 | | Mastigocladopsis repens rhodopsin chloride pump | | 分子名称: | CHLORIDE ION, DECANE, Mastigocladopsis repens rhodopsin chloride pump, ... | | 著者 | Besaw, J.E, Ernst, O.P, Ou, W, Morizumi, T. | | 登録日 | 2020-06-28 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | The crystal structures of a chloride-pumping microbial rhodopsin and its proton-pumping mutant illuminate proton transfer determinants.
J.Biol.Chem., 295, 2020
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3DQB
 | | Crystal structure of the active G-protein-coupled receptor opsin in complex with a C-terminal peptide derived from the Galpha subunit of transducin | | 分子名称: | 11meric peptide form Guanine nucleotide-binding protein G(t) subunit alpha-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, ... | | 著者 | Scheerer, P, Park, J.H, Hildebrand, P.W, Kim, Y.J, Krauss, N, Choe, H.-W, Hofmann, K.P, Ernst, O.P. | | 登録日 | 2008-07-09 | | 公開日 | 2008-09-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal structure of opsin in its G-protein-interacting conformation
Nature, 455, 2008
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3CAP
 | | Crystal Structure of Native Opsin: the G Protein-Coupled Receptor Rhodopsin in its Ligand-free State | | 分子名称: | 2-O-octyl-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, ... | | 著者 | Park, J.H, Scheerer, P, Hofmann, K.P, Choe, H.-W, Ernst, O.P. | | 登録日 | 2008-02-20 | | 公開日 | 2008-06-24 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structure of the ligand-free G-protein-coupled receptor opsin
Nature, 454, 2008
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8EL2
 | | SARS-CoV-2 RBD bound to neutralizing antibody Fab ICO-hu23 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab ICO-hu23 Heavy Chain, Fab ICO-hu23 Light Chain, ... | | 著者 | Besaw, J.E, Kuo, A, Morizumi, T, Ernst, O.P. | | 登録日 | 2022-09-22 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates.
Plos Pathog., 19, 2023
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8ELJ
 | | SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 neutralizing antibody Fab fragment | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ICO-hu23 antibody Fab heavy chain, ... | | 著者 | Yee, A.W, Morizumi, T, Kim, K, Kuo, A, Ernst, O.P. | | 登録日 | 2022-09-24 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates.
Plos Pathog., 19, 2023
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4J4Q
 | | Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside | | 分子名称: | ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, PALMITIC ACID, ... | | 著者 | Park, J.H, Morizumi, T, Li, Y, Hong, J.E, Pai, E.F, Hofmann, K.P, Choe, H.W, Ernst, O.P. | | 登録日 | 2013-02-07 | | 公開日 | 2013-10-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Opsin, a structural model for olfactory receptors?
Angew.Chem.Int.Ed.Engl., 52, 2013
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5WKT
 | | 3.2-Angstrom In situ Mylar structure of bovine opsin at 100 K | | 分子名称: | Rhodopsin, SULFATE ION, Transducin Galpha peptide, ... | | 著者 | Broecker, J, Morizumi, T, Ou, W.-L, Ernst, O.P. | | 登録日 | 2017-07-25 | | 公開日 | 2017-12-13 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions.
Nat Protoc, 13, 2018
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5WJK
 | | 2.0-Angstrom In situ Mylar structure of sperm whale myoglobin (SWMb) at 293 K | | 分子名称: | CHLORIDE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Broecker, J, Ou, W.-L, Ernst, O.P. | | 登録日 | 2017-07-23 | | 公開日 | 2017-12-13 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions.
Nat Protoc, 13, 2018
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7F1W
 | | X-ray crystal structure of visual arrestin complexed with inositol hexaphosphate | | 分子名称: | INOSITOL HEXAKISPHOSPHATE, S-arrestin | | 著者 | Kang, M, Jang, K, Eger, B.T, Ernst, O.P, Choe, H.W, Kim, Y.J. | | 登録日 | 2021-06-10 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.097 Å) | | 主引用文献 | Structural evidence for visual arrestin priming via complexation of phosphoinositols.
Structure, 30, 2022
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7F1X
 | | X-ray crystal structure of visual arrestin complexed with inositol 1,4,5-triphosphate | | 分子名称: | 1,2-ETHANEDIOL, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, PENTANEDIAL, ... | | 著者 | Jang, K, Kang, M, Eger, B.T, Choe, H.W, Ernst, O.P, Kim, Y.J. | | 登録日 | 2021-06-10 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural evidence for visual arrestin priming via complexation of phosphoinositols.
Structure, 30, 2022
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6V51
 | | Spin-labeled T4 Lysozyme (9/131FnbY)-(4-Amino-TEMPO) | | 分子名称: | 4-amino-2,2,6,6-tetramethylpiperidin-1-ol, Endolysin | | 著者 | Liu, J, Morizumi, T, Ou, W.L, Wang, L, Ernst, O.P. | | 登録日 | 2019-12-02 | | 公開日 | 2020-10-07 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Genetically Encoded Quinone Methides Enabling Rapid, Site-Specific, and Photocontrolled Protein Modification with Amine Reagents.
J.Am.Chem.Soc., 142, 2020
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6WP8
 | | Proton-pumping mutant of Mastigocladopsis repens rhodopsin chloride pump | | 分子名称: | Proton-pumping rhodopsin chloride pump, RETINAL, octyl beta-D-glucopyranoside | | 著者 | Besaw, J.E, Ernst, O.P, Ou, W, Morizumi, T. | | 登録日 | 2020-04-26 | | 公開日 | 2020-07-29 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The crystal structures of a chloride-pumping microbial rhodopsin and its proton-pumping mutant illuminate proton transfer determinants.
J.Biol.Chem., 295, 2020
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7JJO
 | | Structural Basis of the Activation of Heterotrimeric Gs-protein by Isoproterenol-bound Beta1-Adrenergic Receptor | | 分子名称: | Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Su, M, Zhu, L, Zhang, Y, Paknejad, N, Dey, R, Huang, J, Lee, M.Y, Williams, D, Jordan, K.D, Eng, E.T, Ernst, O.P, Meyerson, J.R, Hite, R.K, Walz, T, Liu, W, Huang, X.Y. | | 登録日 | 2020-07-27 | | 公開日 | 2020-09-02 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound beta 1 -Adrenergic Receptor.
Mol.Cell, 80, 2020
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8GI9
 | | Cation channelrhodopsin from Hyphochytrium catenoides (HcCCR) embedded in peptidisc | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, Cation Channelrhodopsin, ... | | 著者 | Morizumi, T, Kim, K, Li, H, Spudich, J.L, Ernst, O.P. | | 登録日 | 2023-03-13 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Structures of channelrhodopsin paralogs in peptidiscs explain their contrasting K + and Na + selectivities.
Nat Commun, 14, 2023
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8GI8
 | | Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) embedded in peptidisc | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, Kalium Channelrhodopsin 1, ... | | 著者 | Morizumi, T, Kim, K, Li, H, Spudich, J.L, Ernst, O.P. | | 登録日 | 2023-03-13 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Structures of channelrhodopsin paralogs in peptidiscs explain their contrasting K + and Na + selectivities.
Nat Commun, 14, 2023
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7U55
 | | Crystal structure of Thermoplasmatales archaeon heliorhodopsin at pH 4.5 | | 分子名称: | CHLORIDE ION, DODECANE, Heliorhodopsin, ... | | 著者 | Besaw, J.E, De Guzman, P, Miller, R.J.D, Ernst, O.P. | | 登録日 | 2022-03-01 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Low pH structure of heliorhodopsin reveals chloride binding site and intramolecular signaling pathway.
Sci Rep, 12, 2022
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6BK9
 | | Crystal Structure of Squid Arrestin | | 分子名称: | CHLORIDE ION, Visual arrestin | | 著者 | Eger, B.T, Bandyopadhyay, A, Yedidi, R.S, Ernst, O.P. | | 登録日 | 2017-11-08 | | 公開日 | 2018-09-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.00005579 Å) | | 主引用文献 | A Novel Polar Core and Weakly Fixed C-Tail in Squid Arrestin Provide New Insight into Interaction with Rhodopsin.
J. Mol. Biol., 430, 2018
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3PXO
 | | Crystal structure of Metarhodopsin II | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, RETINAL, ... | | 著者 | Choe, H.-W, Kim, Y.J, Park, J.H, Morizumi, T, Pai, E.F, Krauss, N, Hofmann, K.P, Scheerer, P, Ernst, O.P. | | 登録日 | 2010-12-10 | | 公開日 | 2011-03-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structure of metarhodopsin II.
Nature, 471, 2011
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3PQR
 | | Crystal structure of Metarhodopsin II in complex with a C-terminal peptide derived from the Galpha subunit of transducin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, ... | | 著者 | Choe, H.-W, Kim, Y.J, Park, J.H, Morizumi, T, Pai, E.F, Krauss, N, Hofmann, K.P, Scheerer, P, Ernst, O.P. | | 登録日 | 2010-11-26 | | 公開日 | 2011-03-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Crystal structure of metarhodopsin II.
Nature, 471, 2011
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5V33
 | | R. sphaeroides photosythetic reaction center mutant - Residue L223, Ser to Trp - Room Temperature Structure Solved on X-ray Transparent Microfluidic Chip | | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, FE (III) ION, ... | | 著者 | Schieferstein, J.M, Pawate, A.S, Sun, C, Wan, F, Broecker, J, Ernst, O.P, Gennis, R.B, Kenis, P.J.A. | | 登録日 | 2017-03-06 | | 公開日 | 2017-04-12 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.487 Å) | | 主引用文献 | X-ray transparent microfluidic chips for high-throughput screening and optimization of in meso membrane protein crystallization.
Biomicrofluidics, 11, 2017
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5VRA
 | | 2.35-Angstrom In situ Mylar structure of human A2A adenosine receptor at 100 K | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ... | | 著者 | Broecker, J, Morizumi, T, Ou, W.-L, Klingel, V, Kuo, A, Kissick, D.J, Ishchenko, A, Lee, M.-Y, Xu, S, Makarov, O, Cherezov, V, Ogata, C.M, Ernst, O.P. | | 登録日 | 2017-05-10 | | 公開日 | 2017-12-13 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions.
Nat Protoc, 13, 2018
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5W0P
 | | Crystal structure of rhodopsin bound to visual arrestin determined by X-ray free electron laser | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endolysin,Rhodopsin,S-arrestin | | 著者 | Zhou, X.E, He, Y, de Waal, P.W, Gao, X, Kang, Y, Van Eps, N, Yin, Y, Pal, K, Goswami, D, White, T.A, Barty, A, Latorraca, N.R, Chapman, H.N, Hubbell, W.L, Dror, R.O, Stevens, R.C, Cherezov, V, Gurevich, V.V, Griffin, P.R, Ernst, O.P, Melcher, K, Xu, H.E. | | 登録日 | 2017-05-31 | | 公開日 | 2017-08-09 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.013 Å) | | 主引用文献 | Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.
Cell, 170, 2017
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6OFJ
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