1U43
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![BU of 1u43 by Molmil](/molmil-images/mine/1u43) | IspF with 4-diphosphocytidyl-2c-methyl-D-erythritol 2-phosphate | 分子名称: | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL 2-PHOSPHATE | 著者 | Steinbacher, S, Kaiser, J, Wungsintaweekul, J, Hecht, S, Eisenreich, W, Gerhardt, S, Bacher, A, Rohdich, F. | 登録日 | 2004-07-23 | 公開日 | 2004-08-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure of 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase Involved in Mevalonate Independent Biosynthesis of Isoprenoids J.Mol.Biol., 316, 2002
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5AFW
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![BU of 5afw by Molmil](/molmil-images/mine/5afw) | Assembly of methylated LSD1 and CHD1 drives AR-dependent transcription and translocation | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, ... | 著者 | Metzger, E, Willmann, D, McMillan, J, Petroll, K, Metzger, P, Gerhardt, S, vonMaessenhausen, A, Schott, A.K, Espejo, A, Eberlin, A, Wohlwend, D, Schuele, K.M, Schleicher, M, Perner, S, Bedford, M.T, Dengjel, J, Flaig, R, Einsle, O, Schuele, R. | 登録日 | 2015-01-26 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Assembly of Methylated Kdm1A and Chd1 Drives Androgen Receptor-Dependent Transcription and Translocation. Nat.Struct.Mol.Biol., 23, 2016
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1JY8
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![BU of 1jy8 by Molmil](/molmil-images/mine/1jy8) | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) | 分子名称: | 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, CYTIDINE-5'-MONOPHOSPHATE, ... | 著者 | Steinbacher, S, Kaiser, J, Wungsintaweekul, J, Hecht, S, Eisenreich, W, Gerhardt, S, Bacher, A, Rohdich, F. | 登録日 | 2001-09-11 | 公開日 | 2002-01-30 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids. J.Mol.Biol., 316, 2002
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2A58
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![BU of 2a58 by Molmil](/molmil-images/mine/2a58) | Structure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound riboflavin | 分子名称: | 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION, RIBOFLAVIN | 著者 | Koch, M, Breithaupt, C, Gerhardt, S, Haase, I, Weber, S, Cushman, M, Huber, R, Bacher, A, Fischer, M. | 登録日 | 2005-06-30 | 公開日 | 2005-07-19 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase Eur.J.Biochem., 271, 2004
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2A57
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![BU of 2a57 by Molmil](/molmil-images/mine/2a57) | Structure of 6,7-Dimthyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 6-carboxyethyl-7-oxo-8-ribityllumazine | 分子名称: | 3-[8-((2S,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL)-2,4,7-TRIOXO-1,3,8-TRIHYDROPTERIDIN-6-YL]PROPANOIC ACID, 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | 著者 | Koch, M, Breithaupt, C, Gerhardt, S, Haase, I, Weber, S, Cushman, M, Huber, R, Bacher, A, Fischer, M. | 登録日 | 2005-06-30 | 公開日 | 2005-07-19 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase Eur.J.Biochem., 271, 2004
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2A59
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![BU of 2a59 by Molmil](/molmil-images/mine/2a59) | Structure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 5-nitroso-6-ribitylamino-2,4(1H,3H)-pyrimidinedione | 分子名称: | 5-NITROSO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE, 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | 著者 | Koch, M, Breithaupt, C, Gerhardt, S, Haase, I, Weber, S, Cushman, M, Huber, R, Bacher, A, Fischer, M. | 登録日 | 2005-06-30 | 公開日 | 2005-07-19 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase Eur.J.Biochem., 271, 2004
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5LC9
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5LPM
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![BU of 5lpm by Molmil](/molmil-images/mine/5lpm) | Crystal structure of the bromodomain of human Ep300 bound to the inhibitor XDM3d | 分子名称: | ACETATE ION, Histone acetyltransferase p300, ~{N}-[(1~{S},2~{S})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole -2-carboxamide | 著者 | Huegle, M, Wohlwend, D, Gerhardt, S. | 登録日 | 2016-08-13 | 公開日 | 2017-08-16 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew. Chem. Int. Ed. Engl., 56, 2017
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4IWV
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![BU of 4iwv by Molmil](/molmil-images/mine/4iwv) | Crystals structure of Human Glucokinase in complex with small molecule activator | 分子名称: | (2S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(5-chloropyridin-2-yl)-3-(2-hydroxyethoxy)propanamide, Glucokinase isoform 3, SODIUM ION, ... | 著者 | Ogg, D.J, Hargreaves, D, Gerhardt, S, Flavell, L, McAlister, M. | 登録日 | 2013-01-24 | 公開日 | 2013-04-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets the discovery of AZD3651 and AZD9485 To be Published
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4LYS
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![BU of 4lys by Molmil](/molmil-images/mine/4lys) | Crystal Structure of BRD4(1) bound to Colchiceine | 分子名称: | Bromodomain-containing protein 4, N-[(7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide, SODIUM ION | 著者 | Wohlwend, D, Gerhardt, S, Einsle, O. | 登録日 | 2013-07-31 | 公開日 | 2014-01-15 | 最終更新日 | 2014-01-29 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52, 2013
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4L4Q
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![BU of 4l4q by Molmil](/molmil-images/mine/4l4q) | Methionine Adenosyltransferase | 分子名称: | S-adenosylmethionine synthase | 著者 | Schlesier, J, Siegrist, J, Gerhardt, S, Andexer, J.N, Einsle, O. | 登録日 | 2013-06-09 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis. Bmc Struct.Biol., 13, 2013
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4LYW
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4LZR
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![BU of 4lzr by Molmil](/molmil-images/mine/4lzr) | Crystal Structure of BRD4(1) bound to Colchicine | 分子名称: | Bromodomain-containing protein 4, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide | 著者 | Wohlwend, D, Gerhardt, S, Einsle, O, Huegle, M. | 登録日 | 2013-08-01 | 公開日 | 2014-01-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52, 2013
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5O6M
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4LZS
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![BU of 4lzs by Molmil](/molmil-images/mine/4lzs) | Crystal Structure of BRD4(1) bound to inhibitor XD46 | 分子名称: | 4-acetyl-3-ethyl-N,5-dimethyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 | 著者 | Wohlwend, D, Huegle, M, Einsle, O, Gerhardt, S. | 登録日 | 2013-08-01 | 公開日 | 2014-01-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52, 2013
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8PFH
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![BU of 8pfh by Molmil](/molmil-images/mine/8pfh) | Crystal structure of the yeast septin complex Shs1-Cdc12-Cdc3-Cdc10 | 分子名称: | CDC10 isoform 1, CDC12 isoform 1, Cell division control protein 3, ... | 著者 | Grupp, B, Denkhaus, L, Gerhardt, S, Gronemeyer, T. | 登録日 | 2023-06-16 | 公開日 | 2023-12-06 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | The structure of a tetrameric septin complex reveals a hydrophobic element essential for NC-interface integrity. Commun Biol, 7, 2024
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5O6K
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6Q93
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![BU of 6q93 by Molmil](/molmil-images/mine/6q93) | MgADP-bound Fe protein of Vanadium nitrogenase from Azotobacter vinelandii | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | 著者 | Rohde, M, Gerhardt, S, Einsle, O. | 登録日 | 2018-12-17 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of VnfH, the iron protein component of vanadium nitrogenase. J. Biol. Inorg. Chem., 23, 2018
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4IXC
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5D25
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![BU of 5d25 by Molmil](/molmil-images/mine/5d25) | First bromodomain of BRD4 bound to inhibitor XD27 | 分子名称: | (R,R)-2,3-BUTANEDIOL, 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3,5-dimethyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4, ... | 著者 | Wohlwend, D, Huegle, M, Gerhardt, S. | 登録日 | 2015-08-05 | 公開日 | 2016-01-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
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5D24
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![BU of 5d24 by Molmil](/molmil-images/mine/5d24) | First bromodomain of BRD4 bound to inhibitor XD26 | 分子名称: | 1,2-ETHANEDIOL, 4-acetyl-N-[3-(2-amino-2-oxoethoxy)phenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 | 著者 | Wohlwend, D, Huegle, M, Gerhardt, S. | 登録日 | 2015-08-05 | 公開日 | 2016-01-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
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3JT1
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![BU of 3jt1 by Molmil](/molmil-images/mine/3jt1) | Legionella pneumophila glucosyltransferase Lgt1, UDP-bound form | 分子名称: | Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE | 著者 | Lu, W, Du, J, Belyi, Y, Stahl, M, Zivilikidis, T, Gerhardt, S, Aktories, K, Einsle, O. | 登録日 | 2009-09-11 | 公開日 | 2010-02-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila. J.Mol.Biol., 2009
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3JSZ
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![BU of 3jsz by Molmil](/molmil-images/mine/3jsz) | Legionella pneumophila glucosyltransferase Lgt1 N293A with UDP-Glc | 分子名称: | MAGNESIUM ION, Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE-GLUCOSE | 著者 | Lu, W, Du, J, Belyi, Y, Stahl, M, Zivilikidis, T, Gerhardt, S, Aktories, K, Einsle, O. | 登録日 | 2009-09-11 | 公開日 | 2010-02-02 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila. J.Mol.Biol., 2009
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5G4K
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![BU of 5g4k by Molmil](/molmil-images/mine/5g4k) | Phloroglucinol reductase from Clostridium sp. apo-form | 分子名称: | OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY PROTEIN | 著者 | Conradt, D, Hermann, B, Gerhardt, S, Einsle, O, Mueller, M. | 登録日 | 2016-05-13 | 公開日 | 2016-12-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Biocatalytic Properties and Structural Analysis of Phloroglucinol Reductases. Angew.Chem.Int.Ed.Engl., 55, 2016
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5G4L
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![BU of 5g4l by Molmil](/molmil-images/mine/5g4l) | Phloroglucinol reductase from Clostridium sp. with bound NADPH | 分子名称: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY PROTEIN | 著者 | Conradt, D, Hermann, B, Gerhardt, S, Einsle, O, Mueller, M. | 登録日 | 2016-05-13 | 公開日 | 2016-12-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Biocatalytic Properties and Structural Analysis of Phloroglucinol Reductases. Angew.Chem.Int.Ed.Engl., 55, 2016
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