5LPM

Crystal structure of the bromodomain of human Ep300 bound to the inhibitor XDM3d

Summary for 5LPM

Entry DOI	10.2210/pdb5lpm/pdb
Related	5NRW
Descriptor	Histone acetyltransferase p300, ~{N}-[(1~{S},2~{S})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide, ACETATE ION, ... (4 entities in total)
Functional Keywords	bromodomain, protein-inhibitor complex, epigenetics, transcription
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q09472
Total number of polymer chains	2
Total formula weight	29330.17
Authors	Huegle, M.,Wohlwend, D.,Gerhardt, S. (deposition date: 2016-08-13, release date: 2017-08-16, Last modification date: 2017-10-11)
Primary citation	Hugle, M.,Lucas, X.,Ostrovskyi, D.,Regenass, P.,Gerhardt, S.,Einsle, O.,Hau, M.,Jung, M.,Breit, B.,Gunther, S.,Wohlwend, D. Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew. Chem. Int. Ed. Engl., 56:12476-12480, 2017 Cited by PubMed: 28766825 DOI: 10.1002/anie.201705516 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation