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5LPM

Crystal structure of the bromodomain of human Ep300 bound to the inhibitor XDM3d

Functional Information from GO Data
ChainGOidnamespacecontents
A0004402molecular_functionhistone acetyltransferase activity
A0006355biological_processregulation of DNA-templated transcription
B0004402molecular_functionhistone acetyltransferase activity
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue 71Y A 1201
ChainResidue
ALEU1073
ATYR1131
AASN1132
A71Y1202
AHOH1304
AHOH1313
AHOH1388
APRO1074
AGLN1077
APRO1078
AVAL1079
AASP1080
ALEU1084
AILE1086
ATYR1089

site_idAC2
Number of Residues5
Detailsbinding site for residue ACT A 1203
ChainResidue
APRO1051
AARG1055
ATHR1108
AGLY1109
BGLN1082

site_idAC3
Number of Residues2
Detailsbinding site for residue ACT A 1204
ChainResidue
AARG1137
AHOH1366

site_idAC4
Number of Residues13
Detailsbinding site for residue 71Y B 1201
ChainResidue
AMET1059
APRO1060
ALEU1062
AGLU1063
ATYR1066
ALYS1103
AHOH1341
BTRP1115
BTRP1122
BASN1126
BGLU1150
BHOH1302
BHOH1343

site_idAC5
Number of Residues5
Detailsbinding site for residue ACT B 1203
ChainResidue
AARG1104
AHOH1425
BTHR1101
BARG1104
BHOH1301

site_idAC6
Number of Residues20
Detailsbinding site for residues 71Y A 1202 and 71Y B 1202
ChainResidue
ALEU1083
ALEU1084
A71Y1201
AHOH1304
AHOH1379
AHOH1426
BLEU1073
BPRO1074
BGLN1077
BPRO1078
BVAL1079
BASP1080
BLEU1084
BILE1086
BTYR1131
BASN1132
BARG1137
BHOH1316
BHOH1384
BHOH1390

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVkspMdlstIkrkldtgq..Yqepwqyvddiwl.MfnNAwlY
ChainResidueDetails
ASER1072-TYR1131

226707

PDB entries from 2024-10-30

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