5LPM
Crystal structure of the bromodomain of human Ep300 bound to the inhibitor XDM3d
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone acetyltransferase p300 | polymer | 116 | 13826.8 | 2 | UniProt (Q09472) Pfam (PF00439) | Homo sapiens (Human) | p300 HAT,E1A-associated protein p300 |
| 2 | C, D, G, H (A, B) | ~{N}-[(1~{S},2~{S})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole -2-carboxamide | non-polymer | 374.9 | 4 | Chemie (71Y) | |||
| 3 | E, F, I (A, B) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 332 | Chemie (HOH) |
Sequence modifications
A, B: 1048 - 1161 (UniProt: Q09472)
| PDB | External Database | Details |
|---|---|---|
| Ser 1046 | - | expression tag |
| Met 1047 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27653.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1676.6 | |
| All* | Total formula weight | 29330.2 |
