6UFR
 
 | | Structure of recombinantly assembled E46K alpha-synuclein fibrils | | 分子名称: | Alpha-synuclein | | 著者 | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Li, B, Jiang, L. | | 登録日 | 2019-09-24 | | 公開日 | 2020-02-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
2GLS
 | |
8DU2
 | | HnRNPA2 D290V LCD PM1 | | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | | 登録日 | 2022-07-26 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
|
|
8DUW
 | | HnRNPA2 D290V LCD PM2 | | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | | 登録日 | 2022-07-27 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
|
|
8EC7
 | | HnRNPA2 D290V LCD PM3 | | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | | 登録日 | 2022-09-01 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
|
|
2MLT
 | |
6NK4
 | |
6N4P
 | |
6ODG
 | | SVQIVY, Crystal Structure of a tau protein fragment | | 分子名称: | Microtubule-associated protein tau | | 著者 | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Seidler, P.M. | | 登録日 | 2019-03-26 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.
J.Biol.Chem., 294, 2019
|
|
4ZNN
 | | MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56 | | 分子名称: | Alpha-synuclein | | 著者 | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | | 登録日 | 2015-05-05 | | 公開日 | 2015-09-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.41 Å) | | 主引用文献 | Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
|
|
4UNU
 | | MCG - a dimer of lambda variable domains | | 分子名称: | IG LAMBDA CHAIN V-II REGION MGC, POLYETHYLENE GLYCOL (N=34), SULFATE ION | | 著者 | Brumshtein, B, Esswein, S.R, Landau, M, Ryan, C, Whitelegge, J, Casio, D, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2014-05-30 | | 公開日 | 2014-08-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | | 主引用文献 | Formation of Amyloid Fibers by Monomeric Light-Chain Variable Domains.
J.Biol.Chem., 289, 2014
|
|
4UNT
 | | Induced monomer of the Mcg variable domain | | 分子名称: | IG LAMBDA CHAIN V-II REGION MGC, SULFATE ION | | 著者 | Brumshtein, B, Esswein, S.R, Landau, M, Ryan, C.M, Whitelegge, J.P, Phillips, M.L, Cascio, D, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2014-05-30 | | 公開日 | 2014-08-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Formation of Amyloid Fibers by Monomeric Light-Chain Variable Domains.
J.Biol.Chem., 289, 2014
|
|
5W52
 | | MicroED structure of the segment, DLIIKGISVHI, from the RRM2 of TDP-43, residues 247-257 | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Guenther, E.L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | | 登録日 | 2017-06-13 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.4 Å) | | 主引用文献 | Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.
Nat. Struct. Mol. Biol., 25, 2018
|
|
5WKD
 | | Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43, residues 300-306 | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Guenther, E.L, Trinh, H, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | | 登録日 | 2017-07-25 | | 公開日 | 2018-04-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
|
|
2G38
 | | A PE/PPE Protein Complex from Mycobacterium tuberculosis | | 分子名称: | MANGANESE (II) ION, PE FAMILY PROTEIN, PPE FAMILY PROTEIN | | 著者 | Strong, M, Sawaya, M.R, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2006-02-17 | | 公開日 | 2006-03-14 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.Usa, 103, 2006
|
|
4PM4
 | | Structure of a putative periplasmic iron siderophore binding protein (Rv0265c) from Mycobacterium tuberculosis H37Rv | | 分子名称: | CHLORIDE ION, Iron complex transporter substrate-binding protein, SULFATE ION | | 著者 | Arbing, M.A, Chan, S, Tran, N, Kuo, E, Lu, J, Harris, L.R, Zhou, T.T, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2014-05-20 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of a putative periplasmic iron siderophore binding protein (Rv0265c) from Mycobacterium tuberculosis H37Rv
To Be Published
|
|
3MML
 | | Allophanate Hydrolase Complex from Mycobacterium smegmatis, Msmeg0435-Msmeg0436 | | 分子名称: | Allophanate hydrolase subunit 1, Allophanate hydrolase subunit 2, CHLORIDE ION | | 著者 | Kaufmann, M, Chernishof, I, Shin, A, Germano, D, Sawaya, M.R, Waldo, G.S, Arbing, M.A, Perry, J, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2010-04-20 | | 公開日 | 2010-04-28 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of Allphanate Hydrolase Complex from M. smegmatis, Msmeg0435-Msmeg0436
To be Published
|
|
5WKB
 | | MicroED structure of the segment, NFGEFS, from the A315E familial variant of the low complexity domain of TDP-43, residues 312-317 | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Guenther, E.L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | | 登録日 | 2017-07-24 | | 公開日 | 2018-05-23 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1 Å) | | 主引用文献 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
|
|
5IIW
 | | Corkscrew assembly of SOD1 residues 28-38 without potassium iodide | | 分子名称: | Superoxide dismutase [Cu-Zn] | | 著者 | Sangwan, S, Zhao, A, Sawaya, M.R, Eisenberg, D. | | 登録日 | 2016-03-01 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
6E73
 | | Structure of Human Transthyretin Val30Met Mutant in Complex with Diflunisal | | 分子名称: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, ACETATE ION, Transthyretin | | 著者 | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.797 Å) | | 主引用文献 | Structural Variants of Transthyretin
to be published
|
|
6E75
 | | Structure of Human Transthyretin Asp38Ala Mutant | | 分子名称: | ACETATE ION, Transthyretin | | 著者 | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural Variants of Transthyretin
To Be Published
|
|
6E6Z
 | | Structure of Wild Type Human Transthyretin in Complex with Tafamidis | | 分子名称: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | | 著者 | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural Variants of Transthyretin
To Be Published
|
|
6E77
 | | Structure of Human Transthyretin Asp38Ala Mutant in Complex with Tafamidis | | 分子名称: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | | 著者 | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural Variants of Transthyretin
To Be Published
|
|
1MDT
 | |
7SAS
 | | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | | 著者 | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2021-09-23 | | 公開日 | 2022-03-09 | | 最終更新日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
|
|
