6UFR
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![BU of 6ufr by Molmil](/molmil-images/mine/6ufr) | Structure of recombinantly assembled E46K alpha-synuclein fibrils | Descriptor: | Alpha-synuclein | Authors: | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Li, B, Jiang, L. | Deposit date: | 2019-09-24 | Release date: | 2020-02-19 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure. Proc.Natl.Acad.Sci.USA, 117, 2020
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2GLS
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![BU of 2gls by Molmil](/molmil-images/mine/2gls) | |
8DU2
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![BU of 8du2 by Molmil](/molmil-images/mine/8du2) | HnRNPA2 D290V LCD PM1 | Descriptor: | Heterogeneous nuclear ribonucleoproteins A2/B1 | Authors: | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | Deposit date: | 2022-07-26 | Release date: | 2023-08-02 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J.Biol.Chem., 300, 2023
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8DUW
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![BU of 8duw by Molmil](/molmil-images/mine/8duw) | HnRNPA2 D290V LCD PM2 | Descriptor: | Heterogeneous nuclear ribonucleoproteins A2/B1 | Authors: | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | Deposit date: | 2022-07-27 | Release date: | 2023-08-02 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J.Biol.Chem., 300, 2023
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8EC7
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![BU of 8ec7 by Molmil](/molmil-images/mine/8ec7) | HnRNPA2 D290V LCD PM3 | Descriptor: | Heterogeneous nuclear ribonucleoproteins A2/B1 | Authors: | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | Deposit date: | 2022-09-01 | Release date: | 2023-09-06 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J.Biol.Chem., 300, 2023
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6NK4
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![BU of 6nk4 by Molmil](/molmil-images/mine/6nk4) | |
6ODG
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![BU of 6odg by Molmil](/molmil-images/mine/6odg) | SVQIVY, Crystal Structure of a tau protein fragment | Descriptor: | Microtubule-associated protein tau | Authors: | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Seidler, P.M. | Deposit date: | 2019-03-26 | Release date: | 2019-10-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples. J.Biol.Chem., 294, 2019
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6N4P
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2MLT
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![BU of 2mlt by Molmil](/molmil-images/mine/2mlt) | |
5IIW
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![BU of 5iiw by Molmil](/molmil-images/mine/5iiw) | Corkscrew assembly of SOD1 residues 28-38 without potassium iodide | Descriptor: | Superoxide dismutase [Cu-Zn] | Authors: | Sangwan, S, Zhao, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2016-03-01 | Release date: | 2017-06-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4ZNN
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![BU of 4znn by Molmil](/molmil-images/mine/4znn) | MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56 | Descriptor: | Alpha-synuclein | Authors: | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | Deposit date: | 2015-05-05 | Release date: | 2015-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON CRYSTALLOGRAPHY (1.41 Å) | Cite: | Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525, 2015
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2G38
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![BU of 2g38 by Molmil](/molmil-images/mine/2g38) | A PE/PPE Protein Complex from Mycobacterium tuberculosis | Descriptor: | MANGANESE (II) ION, PE FAMILY PROTEIN, PPE FAMILY PROTEIN | Authors: | Strong, M, Sawaya, M.R, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2006-02-17 | Release date: | 2006-03-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.Usa, 103, 2006
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4PM4
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![BU of 4pm4 by Molmil](/molmil-images/mine/4pm4) | Structure of a putative periplasmic iron siderophore binding protein (Rv0265c) from Mycobacterium tuberculosis H37Rv | Descriptor: | CHLORIDE ION, Iron complex transporter substrate-binding protein, SULFATE ION | Authors: | Arbing, M.A, Chan, S, Tran, N, Kuo, E, Lu, J, Harris, L.R, Zhou, T.T, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2014-05-20 | Release date: | 2014-06-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of a putative periplasmic iron siderophore binding protein (Rv0265c) from Mycobacterium tuberculosis H37Rv To Be Published
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3MML
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![BU of 3mml by Molmil](/molmil-images/mine/3mml) | Allophanate Hydrolase Complex from Mycobacterium smegmatis, Msmeg0435-Msmeg0436 | Descriptor: | Allophanate hydrolase subunit 1, Allophanate hydrolase subunit 2, CHLORIDE ION | Authors: | Kaufmann, M, Chernishof, I, Shin, A, Germano, D, Sawaya, M.R, Waldo, G.S, Arbing, M.A, Perry, J, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2010-04-20 | Release date: | 2010-04-28 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of Allphanate Hydrolase Complex from M. smegmatis, Msmeg0435-Msmeg0436 To be Published
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1MDT
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7SAS
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![BU of 7sas by Molmil](/molmil-images/mine/7sas) | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-09-23 | Release date: | 2022-03-09 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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7SAQ
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![BU of 7saq by Molmil](/molmil-images/mine/7saq) | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-09-23 | Release date: | 2022-03-09 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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7SAR
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![BU of 7sar by Molmil](/molmil-images/mine/7sar) | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-09-23 | Release date: | 2022-03-09 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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5WMJ
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4UNU
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![BU of 4unu by Molmil](/molmil-images/mine/4unu) | MCG - a dimer of lambda variable domains | Descriptor: | IG LAMBDA CHAIN V-II REGION MGC, POLYETHYLENE GLYCOL (N=34), SULFATE ION | Authors: | Brumshtein, B, Esswein, S.R, Landau, M, Ryan, C, Whitelegge, J, Casio, D, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2014-05-30 | Release date: | 2014-08-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Formation of Amyloid Fibers by Monomeric Light-Chain Variable Domains. J.Biol.Chem., 289, 2014
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4UNT
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![BU of 4unt by Molmil](/molmil-images/mine/4unt) | Induced monomer of the Mcg variable domain | Descriptor: | IG LAMBDA CHAIN V-II REGION MGC, SULFATE ION | Authors: | Brumshtein, B, Esswein, S.R, Landau, M, Ryan, C.M, Whitelegge, J.P, Phillips, M.L, Cascio, D, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2014-05-30 | Release date: | 2014-08-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Formation of Amyloid Fibers by Monomeric Light-Chain Variable Domains. J.Biol.Chem., 289, 2014
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4UNV
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![BU of 4unv by Molmil](/molmil-images/mine/4unv) | Covalent dimer of lambda variable domains | Descriptor: | IG LAMBDA CHAIN V-II REGION MGC, SULFATE ION | Authors: | Brumshtein, B, Esswein, S, Landau, M, Ryan, C, Whitelegge, J, Sawaya, M, Eisenberg, D.S. | Deposit date: | 2014-05-30 | Release date: | 2014-08-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Formation of Amyloid Fibers by Monomeric Light-Chain Variable Domains. J.Biol.Chem., 289, 2014
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6E75
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![BU of 6e75 by Molmil](/molmil-images/mine/6e75) | Structure of Human Transthyretin Asp38Ala Mutant | Descriptor: | ACETATE ION, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E6Z
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![BU of 6e6z by Molmil](/molmil-images/mine/6e6z) | Structure of Wild Type Human Transthyretin in Complex with Tafamidis | Descriptor: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E77
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![BU of 6e77 by Molmil](/molmil-images/mine/6e77) | Structure of Human Transthyretin Asp38Ala Mutant in Complex with Tafamidis | Descriptor: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | Authors: | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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