4NFG
 
 | | K13R mutant of horse cytochrome c and yeast cytochrome c peroxidase complex | | 分子名称: | Cytochrome c, Cytochrome c peroxidase, mitochondrial, ... | | 著者 | Meulenbroek, E.M, Bashir, Q, Ubbink, M, Pannu, N.S. | | 登録日 | 2013-10-31 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Engineering specificity in a dynamic protein complex with a single conserved mutation.
Febs J., 281, 2014
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6YWM
 | | Crystal structure of SARS-CoV-2 (Covid-19) NSP3 macrodomain in complex with MES | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, ... | | 著者 | Ni, X, Schroeder, M, Olieric, V, Sharpe, E.M, Wojdyla, J.A, Wang, M, Knapp, S, Chaikuad, A, Structural Genomics Consortium (SGC) | | 登録日 | 2020-04-29 | | 公開日 | 2020-05-06 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain.
Acs Med.Chem.Lett., 12, 2021
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8EHK
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8EHM
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8EHL
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8EHJ
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5DR5
 | | Crystal structure of the sclerostin-neutralizing Fab AbD09097 | | 分子名称: | AbD09097 Fab heavy chain, AbD09097 Fab light chain | | 著者 | Mueller, T.D, Boschert, V, Weidauer, S.E, Muth, E.M, Knappik, A, Frisch, C. | | 登録日 | 2015-09-15 | | 公開日 | 2016-08-31 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Generation and Affinity Maturation of Neutralizing Anti-Sclerostin Antibodies
to be published
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8CQI
 | | Human heparanase in complex with inhibitor R3794 | | 分子名称: | (3~{S},4~{S})-4,5,5-tris(oxidanyl)piperidine-3-carboxylic acid, 1,2-ETHANEDIOL, 1,5-anhydro-D-arabinitol, ... | | 著者 | Moran, E.M, Davies, G.J, Chen, C, Nieuwendijk, E.V, Wu, L, Skoulikopoulou, F, Riet, V.V, Overkleeft, H.S, Armstrong, Z. | | 登録日 | 2023-03-06 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B.
J.Am.Chem.Soc., 146, 2024
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7ARE
 | | DNA origami pointer object v2 | | 分子名称: | SCAFFOLD STRAND, STAPLE STRAND | | 著者 | Thomas, M, Feigl, E, Kohler, F, Kube, M, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | | 登録日 | 2020-10-24 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | | 主引用文献 | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution.
Nat Commun, 11, 2020
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3PF1
 | | E. coli FadL Asp348Ala mutant | | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, LAURYL DIMETHYLAMINE-N-OXIDE, Long-chain fatty acid transport protein | | 著者 | Vandenberg, B, Lepore, B.W, Hearn, E.M, Indic, M, Patel, D. | | 登録日 | 2010-10-27 | | 公開日 | 2011-05-25 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | From the Cover: Ligand-gated diffusion across the bacterial outer membrane.
Proc.Natl.Acad.Sci.USA, 108, 2011
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7AS5
 | | 126 helix bundle DNA nanostructure | | 分子名称: | SCAFFOLD STRAND, STAPLE STRAND | | 著者 | Kube, M, Kohler, F, Feigl, E, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | | 登録日 | 2020-10-27 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (9.8 Å) | | 主引用文献 | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution.
Nat Commun, 11, 2020
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7ART
 | | 48 helix bundle DNA origami brick | | 分子名称: | SCAFFOLD STRAND, STAPLE STRAND | | 著者 | Feigl, E, Kube, M, Kohler, F, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | | 登録日 | 2020-10-26 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (10 Å) | | 主引用文献 | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution.
Nat Commun, 11, 2020
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3PG0
 | | Crystal structure of designed 3-fold symmetric protein, ThreeFoil | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, SODIUM ION, ... | | 著者 | Lobsanov, Y.D, Broom, A, Howell, P.L, Rose, D.R, Meiering, E.M. | | 登録日 | 2010-10-29 | | 公開日 | 2011-12-21 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Modular evolution and the origins of symmetry: reconstruction of a three-fold symmetric globular protein.
Structure, 20, 2012
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5FGG
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5FI3
 | | HETEROYOHIMBINE SYNTHASE THAS1 FROM CATHARANTHUS ROSEUS - COMPLEX WITH NADP+ | | 分子名称: | 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Tetrahydroalstonine synthase, ... | | 著者 | Stavrinides, A, Tatsis, E.C, Caputi, L, Foureau, E, Stevenson, C.E.M, Lawson, D.M, Courdavault, V, O'Connor, S.E. | | 登録日 | 2015-12-22 | | 公開日 | 2016-07-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity.
Nat Commun, 7, 2016
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4NY3
 | | Human PTPA in complex with peptide | | 分子名称: | GLYCEROL, SULFATE ION, Serine/threonine-protein phosphatase 2A activator, ... | | 著者 | Loew, C, Quistgaard, E.M, Nordlund, P. | | 登録日 | 2013-12-10 | | 公開日 | 2014-07-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.797 Å) | | 主引用文献 | Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
Biol.Chem., 395, 2014
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6EIA
 | | PepTSt in complex with HEPES (100 mM) | | 分子名称: | (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Martinez Molledo, M, Quistgaard, E.M, Loew, C. | | 登録日 | 2017-09-18 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter.
Structure, 26, 2018
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6E9Z
 | | DHF119 filament | | 分子名称: | DHF119 filament | | 著者 | Lynch, E.M, Shen, H, Fallas, J.A, Kollman, J.M, Baker, D. | | 登録日 | 2018-08-01 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | De novo design of self-assembling helical protein filaments.
Science, 362, 2018
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5FG7
 | | Yeast 20S proteasome beta2-T1A mutant | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... | | 著者 | Huber, E.M, Groll, M. | | 登録日 | 2015-12-20 | | 公開日 | 2016-03-23 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.
Nat Commun, 7, 2016
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3PGF
 | | Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB) | | 分子名称: | GLYCEROL, IMIDAZOLE, Maltose-binding periplasmic protein, ... | | 著者 | Kossiakoff, A.A, Duguid, E.M, Sandstrom, A. | | 登録日 | 2010-11-01 | | 公開日 | 2011-03-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.
Nat.Struct.Mol.Biol., 18, 2011
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5FGF
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5FI5
 | | HETEROYOHIMBINE SYNTHASE THAS1 FROM CATHARANTHUS ROSEUS - APO FORM | | 分子名称: | PHOSPHATE ION, Tetrahydroalstonine synthase, ZINC ION | | 著者 | Stavrinides, A, Tatsis, E.C, Caputi, L, Foureau, E, Stevenson, C.E.M, Lawson, D.M, Courdavault, V, O'Connor, S.E. | | 登録日 | 2015-12-22 | | 公開日 | 2016-07-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity.
Nat Commun, 7, 2016
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4NB3
 | | Crystal structure of RPA70N in complex with a 3,4 dichlorophenylalanine ATRIP derived peptide | | 分子名称: | 3,4 dichlorophenylalanine ATRIP derived peptide, Replication protein A 70 kDa DNA-binding subunit | | 著者 | Feldkamp, M.D, Frank, A.O, Vangamudi, B, Souza-Fagundes, E.M, Luzwik, J.W, Cortez, D, Olejniczak, O.T, Waterson, A.G, Rossanese, O.W, Fesik, S.W, Chazin, W.J. | | 登録日 | 2013-10-22 | | 公開日 | 2014-02-26 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A.
J.Med.Chem., 57, 2014
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6E9T
 | | DHF58 filament | | 分子名称: | DHF58 filament | | 著者 | Lynch, E.M, Shen, H, Fallas, J.A, Kollman, J.M, Baker, D. | | 登録日 | 2018-08-01 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | | 主引用文献 | De novo design of self-assembling helical protein filaments.
Science, 362, 2018
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5FBK
 | | Crystal structure of the extracellular domain of human calcium sensing receptor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHLORIDE ION, ... | | 著者 | Zhang, T, Zhang, C, Miller, C.L, Zou, J, Moremen, K.W, Brown, E.M, Yang, J.J, Hu, J. | | 登録日 | 2015-12-14 | | 公開日 | 2016-06-22 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.
Sci Adv, 2, 2016
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