4NB3

Crystal structure of RPA70N in complex with a 3,4 dichlorophenylalanine ATRIP derived peptide

Summary for 4NB3

Entry DOI	10.2210/pdb4nb3/pdb
Descriptor	Replication protein A 70 kDa DNA-binding subunit, 3,4 dichlorophenylalanine ATRIP derived peptide (3 entities in total)
Functional Keywords	ob fold, protein-protein interaction, 3, 4 dichlorophenylalanine, peptide binding protein
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P27694
Total number of polymer chains	4
Total formula weight	31395.78
Authors	Feldkamp, M.D.,Frank, A.O.,Vangamudi, B.,Souza-Fagundes, E.M.,Luzwik, J.W.,Cortez, D.,Olejniczak, O.T.,Waterson, A.G.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (deposition date: 2013-10-22, release date: 2014-02-26, Last modification date: 2023-09-20)
Primary citation	Frank, A.O.,Vangamudi, B.,Feldkamp, M.D.,Souza-Fagundes, E.M.,Luzwick, J.W.,Cortez, D.,Olejniczak, E.T.,Waterson, A.G.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W. Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A. J.Med.Chem., 57:2455-2461, 2014 Cited by PubMed: 24491171 DOI: 10.1021/jm401730y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation