8STX
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6O9M
| Structure of the human apo TFIIH | 分子名称: | CDK-activating kinase assembly factor MAT1, General transcription factor IIH subunit 1, General transcription factor IIH subunit 2, ... | 著者 | Yan, C.L, Dodd, T, He, Y, Tainer, J.A, Tsutakawa, S.E, Ivanov, I. | 登録日 | 2019-03-14 | 公開日 | 2019-05-29 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Transcription preinitiation complex structure and dynamics provide insight into genetic diseases. Nat.Struct.Mol.Biol., 26, 2019
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4TRD
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4TRT
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6UI4
| Crystal structure of phenamacril-bound F. graminearum myosin I | 分子名称: | Calmodulin, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Zhou, Y, Zhou, X.E, Gong, Y, Zhu, Y, Xu, H.E, Zhou, M, Melcher, K, Zhang, F. | 登録日 | 2019-09-30 | 公開日 | 2020-03-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural basis of Fusarium myosin I inhibition by phenamacril. Plos Pathog., 16, 2020
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6OH1
| IgA1 Protease G5 domain structure | 分子名称: | Immunoglobulin A1 protease | 著者 | Eisenmesser, E.Z, Chi, Y.C, Paukovich, N, Redzic, J.S, Rahkola, J.T, Janoff, E.N. | 登録日 | 2019-04-04 | 公開日 | 2020-02-26 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Streptococcus pneumoniae G5 domains bind different ligands. Protein Sci., 28, 2019
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6QPJ
| Human CLOCK PAS-A domain | 分子名称: | Circadian locomoter output cycles protein kaput | 著者 | Kwon, H, Freeman, S.L, Moody, P.C.E, Raven, E.L, Basran, J. | 登録日 | 2019-02-14 | 公開日 | 2019-09-25 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.315 Å) | 主引用文献 | Heme binding to human CLOCK affects interactions with the E-box. Proc.Natl.Acad.Sci.USA, 116, 2019
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8BY4
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8SGO
| Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Legesse, D.H, Fan, C, Teng, J, Zhuang, Y, Howard, R.J, Noviello, C.M, Lindahl, E, Hibbs, R.E. | 登録日 | 2023-04-12 | 公開日 | 2023-08-30 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Structural insights into opposing actions of neurosteroids on GABA A receptors. Nat Commun, 14, 2023
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8G9Q
| Tricomplex of Compound-1, KRAS G12C, and CypA | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | 登録日 | 2023-02-21 | 公開日 | 2023-08-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS. Science, 381, 2023
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8G9P
| Tricomplex of RMC-4998, KRAS G12C, and CypA | 分子名称: | (2S)-2-{(5S)-7-[(2E)-4-(dimethylamino)-4-methylpent-2-enoyl]-1-oxo-2,7-diazaspiro[4.4]nonan-2-yl}-N-[(1P,8S,10R,14S,21M)-22-ethyl-21-{2-[(1S)-1-methoxyethyl]pyridin-3-yl}-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.1~2,6~.1~10,14~.0~23,27~]nonacosa-1(25),2(29),3,5,20,23,26-heptaen-8-yl]-3-methylbutanamide (non-preferred name), CHLORIDE ION, GTPase KRas, ... | 著者 | Tomlinson, A.C.A, Saldajeno-Concar, M, Knox, J.E, Yano, J.K. | 登録日 | 2023-02-21 | 公開日 | 2023-08-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS. Science, 381, 2023
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4TYE
| Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase | 分子名称: | Fibroblast growth factor receptor 4, PHOSPHATE ION | 著者 | Lesca, E, Lammens, A, Huber, R, Augustin, M. | 登録日 | 2014-07-08 | 公開日 | 2014-09-24 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural analysis of the human fibroblast growth factor receptor 4 kinase. J.Mol.Biol., 426, 2014
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4TXY
| Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog | 分子名称: | Cyclic AMP-GMP synthase, MAGNESIUM ION | 著者 | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | 登録日 | 2014-07-07 | 公開日 | 2014-08-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.0001 Å) | 主引用文献 | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
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4TYH
| Ternary complex of P38 and MK2 with a P38 inhibitor | 分子名称: | MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | 著者 | Cumming, J.G, Debreczeni, J.E, Edfeldt, F, Evertsson, F, Harrison, M, Holdgate, G, James, M, Lamont, S, Oldham, K, Sullivan, J.E, Wells, S. | 登録日 | 2014-07-08 | 公開日 | 2015-07-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Discovery of substrate selective, ATP-competitive P38 alpha MAP kinase inhibitors To Be Published
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6UH3
| Crystal structure of bacterial heliorhodopsin 48C12 | 分子名称: | DI(HYDROXYETHYL)ETHER, Heliorhodopsin, PALMITIC ACID, ... | 著者 | Lu, Y, Zhou, X.E, Gao, X, Xia, R, Xu, Z, Wang, N, Leng, Y, Melcher, K, Xu, H.E, He, Y. | 登録日 | 2019-09-26 | 公開日 | 2019-12-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of heliorhodopsin 48C12. Cell Res., 30, 2020
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8E9A
| Crystal structure of AsfvPolX in complex with 10-23 DNAzyme and Mg | 分子名称: | DNA/RNA (52-MER), MAGNESIUM ION, Repair DNA polymerase X, ... | 著者 | Cramer, E.R, Robart, A.R, Kaya, A.I. | 登録日 | 2022-08-26 | 公開日 | 2023-06-21 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Structure of a 10-23 deoxyribozyme exhibiting a homodimer conformation. Commun Chem, 6, 2023
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6TVE
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8SEB
| Cryo-EM structure of a single loaded human UBA7-UBE2L6-ISG15 adenylate complex | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | 著者 | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | 登録日 | 2023-04-08 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
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7SHQ
| Structure of a functional construct of eukaryotic elongation factor 2 kinase in complex with calmodulin. | 分子名称: | CALCIUM ION, Calmodulin-1, Eukaryotic elongation factor 2 kinase,Eukaryotic elongation factor 2 kinase, ... | 著者 | Piserchio, A, Isiorho, E.A, Jeruzalmi, D, Dalby, K.N, Ghose, R. | 登録日 | 2021-10-11 | 公開日 | 2022-04-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase. Sci Adv, 8, 2022
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5I7M
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4TXD
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4U28
| Crystal structure of apo Phosphoribosyl isomerase A from Streptomyces sviceus ATCC 29083 | 分子名称: | PHOSPHATE ION, Phosphoribosyl isomerase A | 著者 | Chang, C, Verduzco-Castro, E.A, Endres, M, Barona-Gomez, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-07-16 | 公開日 | 2014-07-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Co-occurrence of analogous enzymes determines evolution of a novel ( beta alpha )8-isomerase sub-family after non-conserved mutations in flexible loop. Biochem. J., 473, 2016
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8OFN
| Structure of the yellow fever virus (Asibi strain) dimeric envelope protein | 分子名称: | Envelope glycoprotein, SULFATE ION | 著者 | Covernton, E, Vaney, M.C, Barba-Spaeth, G, Rey, F.A. | 登録日 | 2023-03-16 | 公開日 | 2023-08-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.48 Å) | 主引用文献 | New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex. Mbio, 14, 2023
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4TZI
| Structure of unliganded Lyn SH2 domain | 分子名称: | Tyrosine-protein kinase Lyn | 著者 | Wybenga-Groot, L.E. | 登録日 | 2014-07-10 | 公開日 | 2015-01-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity. Mol.Cell Proteomics, 14, 2015
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5IG3
| Crystal structure of the human CaMKII-alpha hub | 分子名称: | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 著者 | McSpadden, E, Cao, Y.M, Bhattacharyya, M, Gee, C.L, Barros, T, Kuriyan, J. | 登録日 | 2016-02-26 | 公開日 | 2016-03-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II. Elife, 5, 2016
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