4M7T
| Crystal structure of BtrN in complex with AdoMet and 2-DOIA | Descriptor: | (1R,2S,3S,4R,5S)-5-aminocyclohexane-1,2,3,4-tetrol, BtrN, GLYCEROL, ... | Authors: | Drennan, C.L, Goldman, P.J. | Deposit date: | 2013-08-12 | Release date: | 2013-10-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry. Proc.Natl.Acad.Sci.USA, 110, 2013
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3SCH
| Co(II)-HppE with R-HPP | Descriptor: | COBALT (II) ION, Epoxidase, [(2R)-2-hydroxypropyl]phosphonic acid | Authors: | Drennan, C.L. | Deposit date: | 2011-06-07 | Release date: | 2011-07-06 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis. J.Am.Chem.Soc., 133, 2011
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3SCG
| Fe(II)-HppE with R-HPP | Descriptor: | Epoxidase, FE (II) ION, [(2R)-2-hydroxypropyl]phosphonic acid | Authors: | Drennan, C.L. | Deposit date: | 2011-06-07 | Release date: | 2011-07-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis. J.Am.Chem.Soc., 133, 2011
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3SCF
| Fe(II)-HppE with S-HPP and NO | Descriptor: | (S)-2-HYDROXYPROPYLPHOSPHONIC ACID, Epoxidase, FE (II) ION, ... | Authors: | Drennan, C.L. | Deposit date: | 2011-06-07 | Release date: | 2011-07-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis. J.Am.Chem.Soc., 133, 2011
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1JQK
| Crystal structure of carbon monoxide dehydrogenase from Rhodospirillum rubrum | Descriptor: | FE (II) ION, FE(3)-NI(1)-S(4) CLUSTER, IRON/SULFUR CLUSTER, ... | Authors: | Drennan, C.L, Heo, J, Sintchak, M.D, Schreiter, E, Ludden, P.W. | Deposit date: | 2001-08-07 | Release date: | 2001-10-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase. Proc.Natl.Acad.Sci.USA, 98, 2001
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4XJK
| Crystal structure of Mn(II) Ca(II) Na(I) bound calprotectin | Descriptor: | CALCIUM ION, MANGANESE (II) ION, Protein S100-A8, ... | Authors: | Drennan, C.L, Bowman, S.E.J. | Deposit date: | 2015-01-08 | Release date: | 2015-04-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Manganese Binding Properties of Human Calprotectin under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced Electron Paramagnetic Resonance Spectroscopic Analysis. J.Am.Chem.Soc., 137, 2015
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1BMT
| HOW A PROTEIN BINDS B12: A 3.O ANGSTROM X-RAY STRUCTURE OF THE B12-BINDING DOMAINS OF METHIONINE SYNTHASE | Descriptor: | CO-METHYLCOBALAMIN, METHIONINE SYNTHASE | Authors: | Drennan, C.L, Huang, S, Drummond, J.T, Matthews, R.G, Ludwig, M.L. | Deposit date: | 1994-09-02 | Release date: | 1995-06-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase. Science, 266, 1994
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4J1X
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4J1W
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1CZU
| REFINED STRUCTURES OF OXIDIZED FLAVODOXIN FROM ANACYSTIS NIDULANS | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVODOXIN | Authors: | Drennan, C.L, Pattridge, K.A, Weber, C.H, Metzger, A.L, Hoover, D.M, Ludwig, M.L. | Deposit date: | 1999-09-07 | Release date: | 1999-12-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Refined structures of oxidized flavodoxin from Anacystis nidulans. J.Mol.Biol., 294, 1999
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1D03
| REFINED STRUCTURES OF OXIDIZED FLAVODOXIN FROM ANACYSTIS NIDULANS | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVODOXIN | Authors: | Drennan, C.L, Pattridge, K.A, Weber, C.H, Metzger, A.L, Hoover, D.M, Ludwig, M.L. | Deposit date: | 1999-09-08 | Release date: | 1999-12-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Refined structures of oxidized flavodoxin from Anacystis nidulans. J.Mol.Biol., 294, 1999
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4DJD
| Crystal structure of folate-free corrinoid iron-sulfur protein (CFeSP) in complex with its methyltransferase (MeTr) | Descriptor: | 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase, CALCIUM ION, COBALAMIN, ... | Authors: | Kung, Y, Doukov, T.I, Blasiak, L.C, Drennan, C.L. | Deposit date: | 2012-02-01 | Release date: | 2012-03-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Visualizing molecular juggling within a B12-dependent methyltransferase complex. Nature, 484, 2012
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4DJF
| Crystal structure of folate-bound corrinoid iron-sulfur protein (CFeSP) in complex with its methyltransferase (MeTr), co-crystallized with folate and Ti(III) citrate reductant | Descriptor: | 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase, CALCIUM ION, ... | Authors: | Kung, Y, Drennan, C.L. | Deposit date: | 2012-02-01 | Release date: | 2012-03-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Visualizing molecular juggling within a B12-dependent methyltransferase complex. Nature, 484, 2012
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6EFN
| Structure of a RiPP maturase, SkfB | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | Authors: | Grell, T.A.J, Drennan, C.L. | Deposit date: | 2018-08-16 | Release date: | 2018-10-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.291 Å) | Cite: | Structure of a RiPP maturase, SkfB J.Biol.Chem., 2018
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6UO0
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8DPB
| MeaB in complex with the cobalamin-binding domain of its target mutase with GMPPCP bound | Descriptor: | GLYCEROL, MAGNESIUM ION, Methylmalonyl-CoA mutase accessory protein, ... | Authors: | Vaccaro, F.A, Born, D.A, Drennan, C.L. | Deposit date: | 2022-07-15 | Release date: | 2023-03-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Structure of metallochaperone in complex with the cobalamin-binding domain of its target mutase provides insight into cofactor delivery. Proc.Natl.Acad.Sci.USA, 120, 2023
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7MDI
| Structure of the Neisseria gonorrhoeae ribonucleotide reductase in the inactive state | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Levitz, T.S, Drennan, C.L, Brignole, E.J. | Deposit date: | 2021-04-05 | Release date: | 2022-01-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Effects of chameleon dispense-to-plunge speed on particle concentration, complex formation, and final resolution: A case study using the Neisseria gonorrhoeae ribonucleotide reductase inactive complex. J.Struct.Biol., 214, 2021
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6OND
| Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase produced without CooC, reduced | Descriptor: | CHLORIDE ION, Carbon monoxide dehydrogenase, FE (III) ION, ... | Authors: | Wittenborn, E.C, Cohen, S.E, Drennan, C.L. | Deposit date: | 2019-04-21 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.723 Å) | Cite: | Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase. J.Biol.Chem., 294, 2019
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2E4G
| RebH with bound L-Trp | Descriptor: | TRYPTOPHAN, Tryptophan halogenase | Authors: | Blasiak, L.C, Drennan, C.L. | Deposit date: | 2006-12-07 | Release date: | 2007-02-13 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases Biochemistry, 46, 2007
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2E7F
| 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 Angsrom resolution | Descriptor: | 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase, CALCIUM ION | Authors: | Doukov, T.I, Drennan, C.L, Hemmi, H, Ragsdale, S.W. | Deposit date: | 2007-01-09 | Release date: | 2007-01-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases. J.Biol.Chem., 282, 2007
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6AUI
| Human ribonucleotide reductase large subunit (alpha) with dATP and CDP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Brignole, E.J, Drennan, C.L, Asturias, F.J, Tsai, K.L, Penczek, P.A. | Deposit date: | 2017-09-01 | Release date: | 2018-04-18 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | 3.3- angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife, 7, 2018
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6B6X
| Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase, dithionite-reduced (protein batch 2), canonical C-cluster | Descriptor: | CHLORIDE ION, Carbon monoxide dehydrogenase, FE(4)-NI(1)-S(4) CLUSTER, ... | Authors: | Wittenborn, E.C, Drennan, C.L. | Deposit date: | 2017-10-03 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase. Elife, 7, 2018
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2Z8Y
| Xenon-bound structure of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase(CODH/ACS) from Moorella thermoacetica | Descriptor: | COPPER (I) ION, Carbon monoxide dehydrogenase/acetyl CoA synthase subunit alpha, Carbon monoxide dehydrogenase/acetyl CoA synthase subunit beta, ... | Authors: | Doukov, T.I, Blasiak, L.C, Drennan, C.L. | Deposit date: | 2007-09-12 | Release date: | 2008-03-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Xenon in and at the End of the Tunnel of Bifunctional Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase Biochemistry, 47, 2008
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8V9I
| 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Deinococcus radiodurans with D-phenylalanine-derived triazole acetylphosphonate (D-PheTrAP) bound | Descriptor: | 1-deoxy-D-xylulose-5-phosphate synthase, 2-HYDROXY BUTANE-1,4-DIOL, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1S)-1-[(S)-(2-{1-[(1R)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-4-yl}ethoxy)(hydroxy)phosphoryl]-1-hydroxyethyl}-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, ... | Authors: | Chen, P.Y.-T, Drennan, C.L. | Deposit date: | 2023-12-08 | Release date: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.981 Å) | Cite: | Potent Inhibition of E. coli DXP Synthase by a gem -Diaryl Bisubstrate Analog. Acs Infect Dis., 10, 2024
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4XC7
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