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PDB: 214 results

1EKG
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BU of 1ekg by Molmil
MATURE HUMAN FRATAXIN
Descriptor: FRATAXIN
Authors:Dhe-Paganon, S, Shigeta, R, Chi, Y.I, Ristow, M, Shoelson, S.E.
Deposit date:2000-03-08
Release date:2000-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human frataxin.
J.Biol.Chem., 275, 2000
1M7W
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BU of 1m7w by Molmil
HNF4a ligand binding domain with bound fatty acid
Descriptor: Hepatocyte nuclear factor 4-alpha, LAURIC ACID
Authors:Dhe-Paganon, S, Duda, K, Iwamoto, M, Chi, Y.I, Shoelson, S.E.
Deposit date:2002-07-22
Release date:2003-07-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand
J.Biol.Chem., 277, 2002
1IFR
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Structure of Lamin A/C Globular Domain
Descriptor: GLYCEROL, Lamin A/C
Authors:Dhe-Paganon, S, Werner, E.D, Shoelson, S.E.
Deposit date:2001-04-13
Release date:2002-07-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of the globular tail of nuclear lamin.
J.Biol.Chem., 277, 2002
1QQG
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BU of 1qqg by Molmil
CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1
Descriptor: INSULIN RECEPTOR SUBSTRATE 1
Authors:Dhe-Paganon, S, Shoelson, S.E.
Deposit date:1999-06-04
Release date:1999-08-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Proc.Natl.Acad.Sci.USA, 96, 1999
1Q2H
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BU of 1q2h by Molmil
Phenylalanine Zipper Mediates APS Dimerization
Descriptor: adaptor protein with pleckstrin homology and src homology 2 domains
Authors:Dhe-Paganon, S, Werner, E.D, Nishi, M, Chi, Y.-I, Shoelson, S.E.
Deposit date:2003-07-24
Release date:2004-08-03
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A phenylalanine zipper mediates APS dimerization.
Nat.Struct.Mol.Biol., 11, 2004
6P38
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BU of 6p38 by Molmil
Crystal Structure Analysis of TAF1 Bromodomain
Descriptor: 4-{[(3R)-4-cyclopentyl-1,3-dimethyl-2-oxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl]amino}-N-(1-methylpiperidin-4-yl)-3-[(propan-2-yl)oxy]benzamide, Transcription initiation factor TFIID subunit 1
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2019-05-23
Release date:2020-05-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold.
Acs Med.Chem.Lett., 10, 2019
3F0N
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Mus Musculus Mevalonate Pyrophosphate Decarboxylase
Descriptor: MEVALONATE PYROPHOSPHATE DECARBOXYLASE, PHOSPHATE ION
Authors:Walker, J.R, Davis, T, Vesterberg, A, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2008-10-25
Release date:2008-11-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Mus Musculus Mevalonate Pyrophosphate Decarboxylase
To be Published
5TWL
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BU of 5twl by Molmil
Structure of Maternal Embryonic Leucine Zipper Kinase
Descriptor: 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3,4-dihydropyrimido[5,4-c]quinolin-2(1H)-one, Maternal embryonic leucine zipper kinase
Authors:Seo, H.-S, Huang, H.-T, Gray, N.S, Dhe-Paganon, S.
Deposit date:2016-11-14
Release date:2017-11-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:MELK is not necessary for the proliferation of basal-like breast cancer cells.
Elife, 6, 2017
5TWZ
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BU of 5twz by Molmil
Structure of Maternal Embryonic Leucine Zipper Kinase
Descriptor: 7-{[2-methoxy-4-(1H-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1H-3-benzazepinium, Maternal embryonic leucine zipper kinase
Authors:Seo, H.-Y, Dhe-Paganon, S.
Deposit date:2016-11-15
Release date:2017-11-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.631 Å)
Cite:MELK is not necessary for the proliferation of basal-like breast cancer cells.
Elife, 6, 2017
7SZC
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BU of 7szc by Molmil
Crystal Structure Analysis of human PRPK complex with a compound
Descriptor: 4-hydroxy-2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione, D(-)-TARTARIC ACID, EKC/KEOPS complex subunit TP53RK, ...
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2021-11-27
Release date:2022-12-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Development of PRPK Directed Phthalimides
Biorxiv, 2021
7SZD
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Crystal Structure Analysis of human PRPK complex with a compound
Descriptor: 2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid, EKC/KEOPS complex subunit TP53RK, EKC/KEOPS complex subunit TPRKB
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2021-11-27
Release date:2022-12-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Development of PRPK Directed Phthalimides
Biorxiv, 2021
7SZB
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Crystal Structure Analysis of human PRPK complex with a compound
Descriptor: 5-amino-2-[(3R)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione, CITRATE ANION, EKC/KEOPS complex subunit TP53RK, ...
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2021-11-27
Release date:2023-01-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Development of PRPK Directed Phthalimides
Biorxiv, 2021
7SZA
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Crystal Structure Analysis of human PRPK complex with a compound
Descriptor: 4-amino-2-[(3R)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione, CITRATE ANION, EKC/KEOPS complex subunit TP53RK, ...
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2021-11-27
Release date:2023-01-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Development of PRPK Directed Phthalimides
Biorxiv, 2021
4WVL
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BU of 4wvl by Molmil
Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Histone-lysine N-methyltransferase, ...
Authors:Xu, X, Dhe-Paganon, S, Blacklow, S.
Deposit date:2014-11-06
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement.
Acs Chem.Biol., 10, 2015
7S7G
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BU of 7s7g by Molmil
Crystal Structure Analysis of Human VLCAD
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2021-09-15
Release date:2022-09-28
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency.
Nat Commun, 13, 2022
6DUN
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BU of 6dun by Molmil
Crystal Structure Analysis of PIN1
Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, TRIHYDROXYARSENITE(III)
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2018-06-21
Release date:2019-03-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.
Nat Commun, 9, 2018
4WJL
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BU of 4wjl by Molmil
Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Inactive dipeptidyl peptidase 10, ...
Authors:Bezerra, G.A, Dobrovetsky, E, Seitova, A, Fedosyuk, S, Dhe-Paganon, S, Gruber, K.
Deposit date:2014-09-30
Release date:2015-03-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels.
Sci Rep, 5, 2015
1Y6L
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BU of 1y6l by Molmil
Human ubiquitin conjugating enzyme E2E2
Descriptor: Ubiquitin-conjugating enzyme E2E2
Authors:Walker, J.R, Avvakumov, G.V, Newman, E.M, Mackenzie, F, Kozieradzki, I, Bochkarev, A, Sundstrom, M, Arrowsmith, C, Edwards, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2004-12-06
Release date:2005-01-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
Mol Cell Proteomics, 11, 2012
8ECM
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BU of 8ecm by Molmil
Crystal Structure Analysis of Acetyl-CoA acetyltransferase from Firmicutes bacterium
Descriptor: Acetyl-CoA acetyltransferase
Authors:Seo, H.S, Dhe-Paganon, S.
Deposit date:2022-09-02
Release date:2023-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease.
Nat Med, 29, 2023
5JWM
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BU of 5jwm by Molmil
Bivalent BET Bromodomain Inhibition
Descriptor: 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]ethanamide, Bromodomain-containing protein 4
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2016-05-12
Release date:2016-07-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Design and characterization of bivalent BET inhibitors.
Nat.Chem.Biol., 12, 2016
8CUC
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BU of 8cuc by Molmil
Crystal structure analysis of SALL4 zinc finger domain in complex with DNA
Descriptor: DNA (5'-D(P*CP*GP*AP*AP*AP*TP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*TP*AP*TP*TP*TP*CP*G)-3'), Sal-like protein 4, ...
Authors:Seo, H.S, Dhe-Paganon, S.
Deposit date:2022-05-17
Release date:2023-05-24
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal Structure Analysis of SALL4 Zinc Finger domain in complex with DNA
To Be Published
7LI5
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BU of 7li5 by Molmil
Crystal Structure Analysis of human TEAD1
Descriptor: 1-[(3R,4R)-3-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]-4-{[4-(trifluoromethyl)phenyl]methoxy}pyrrolidin-1-yl]prop-2-en-1-one, SULFATE ION, Transcriptional enhancer factor TEF-1
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2021-01-26
Release date:2022-02-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Crystal Structure Analysis of human TEAD1
To Be Published
7MKX
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Crystal Structure Analysis of human CDK2 and CCNA2 complex
Descriptor: 2-[(5-bromo-2-{4-[(cyanomethyl)sulfamoyl]anilino}pyrimidin-4-yl)amino]-6-fluorobenzamide, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2021-04-27
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Crystal Structure Analysis of human CDK2 and CCNA2 complex
To Be Published
8EBK
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Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog
Descriptor: ACE-LEU-THR-PHE-0EH-GLU-TYR-TRP-ALA-GLN-LEU-MK8-SER-ALA-ALA, HDMX
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2022-08-31
Release date:2023-10-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog
To Be Published
6MBW
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Structure of Transcription Factor
Descriptor: Signal transducer and activator of transcription 5B
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2018-08-30
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Structural and functional consequences of the STAT5BN642H driver mutation.
Nat Commun, 10, 2019

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