5VSK

Structure of DUB complex

Summary for 5VSK

Entry DOI	10.2210/pdb5vsk/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase 7, 7-chloro-3-({4-hydroxy-1-[(3S)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one, ZINC ION, ... (4 entities in total)
Functional Keywords	deubiquitinase, inhibitor, protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q93009
Total number of polymer chains	2
Total formula weight	83150.19
Authors	Seo, H.-Y.,Dhe-Paganon, S. (deposition date: 2017-05-11, release date: 2017-12-20, Last modification date: 2018-01-03)
Primary citation	Lamberto, I.,Liu, X.,Seo, H.S.,Schauer, N.J.,Iacob, R.E.,Hu, W.,Das, D.,Mikhailova, T.,Weisberg, E.L.,Engen, J.R.,Anderson, K.C.,Chauhan, D.,Dhe-Paganon, S.,Buhrlage, S.J. Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7. Cell Chem Biol, 24:1490-1500.e11, 2017 Cited by PubMed: 29056421 DOI: 10.1016/j.chembiol.2017.09.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.33 Å)

Structure validation