5VS6
Structure of DUB complex
Summary for 5VS6
Entry DOI | 10.2210/pdb5vs6/pdb |
Related | 5VSB |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 7, N-[3-({4-hydroxy-1-[(3R)-3-phenylbutanoyl]piperidin-4-yl}methyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-3-(4-methylpiperazin-1-yl)propanamide, ACETATE ION, ... (5 entities in total) |
Functional Keywords | deubiquitinase, inhibitor, protein-inhibitor complex, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q93009 |
Total number of polymer chains | 2 |
Total formula weight | 83368.29 |
Authors | Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2017-05-11, release date: 2017-12-20, Last modification date: 2018-01-03) |
Primary citation | Lamberto, I.,Liu, X.,Seo, H.S.,Schauer, N.J.,Iacob, R.E.,Hu, W.,Das, D.,Mikhailova, T.,Weisberg, E.L.,Engen, J.R.,Anderson, K.C.,Chauhan, D.,Dhe-Paganon, S.,Buhrlage, S.J. Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7. Cell Chem Biol, 24:1490-1500.e11, 2017 Cited by PubMed: 29056421DOI: 10.1016/j.chembiol.2017.09.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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