8RIH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8rih by Molmil](/molmil-images/mine/8rih) | Crystal structure of the Saccharomyces cerevisiae URH1p riboside hydrolase | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Uridine ribohydrolase | Authors: | Degano, M, Carriles, A.A. | Deposit date: | 2023-12-18 | Release date: | 2024-07-03 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Structure-Function Insights into the Dual Role in Nucleobase and Nicotinamide Metabolism and a Possible Use in Cancer Gene Therapy of the URH1p Riboside Hydrolase. Int J Mol Sci, 25, 2024
|
|
1MAS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mas by Molmil](/molmil-images/mine/1mas) | PURINE NUCLEOSIDE HYDROLASE | Descriptor: | INOSINE-URIDINE NUCLEOSIDE N-RIBOHYDROLASE, POTASSIUM ION | Authors: | Degano, M, Gopaul, D.N, Scapin, G, Schramm, V.L, Sacchettini, J.C. | Deposit date: | 1995-12-18 | Release date: | 1996-08-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata. Biochemistry, 35, 1996
|
|
1G6R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1g6r by Molmil](/molmil-images/mine/1g6r) | A FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEX | Descriptor: | ALPHA T CELL RECEPTOR, BETA T CELL RECEPTOR, BETA-2 MICROGLOBULIN, ... | Authors: | Degano, M, Garcia, K.C, Apostolopoulos, V, Rudolph, M.G, Teyton, L, Wilson, I.A. | Deposit date: | 2000-11-07 | Release date: | 2000-11-15 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. Immunity, 12, 2000
|
|
6S81
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6s81 by Molmil](/molmil-images/mine/6s81) | Crystal structure of methionine adenosyltransferase from Pyrococcus furiosus | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MANGANESE (II) ION, ... | Authors: | Degano, M, Minici, C, Porcelli, M. | Deposit date: | 2019-07-08 | Release date: | 2020-02-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.784 Å) | Cite: | Structures of catalytic cycle intermediates of the Pyrococcus furiosus methionine adenosyltransferase demonstrate negative cooperativity in the archaeal orthologues. J.Struct.Biol., 210, 2020
|
|
2MAS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mas by Molmil](/molmil-images/mine/2mas) | PURINE NUCLEOSIDE HYDROLASE WITH A TRANSITION STATE INHIBITOR | Descriptor: | 2-(4-AMINO-PHENYL)-5-HYDROXYMETHYL-PYRROLIDINE-3,4-DIOL, CALCIUM ION, INOSINE-URIDINE NUCLEOSIDE N-RIBOHYDROLASE | Authors: | Degano, M, Schramm, V.L, Sacchettini, J.C. | Deposit date: | 1996-10-17 | Release date: | 1997-08-12 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor. Biochemistry, 37, 1998
|
|
6S83
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6s83 by Molmil](/molmil-images/mine/6s83) | Crystal structure of methionine adenosyltransferase from Pyrococcus furiosus in complex with AMPPCP, SAM, and PCP | Descriptor: | MAGNESIUM ION, METHYLENEDIPHOSPHONIC ACID, PHOSPHATE ION, ... | Authors: | Degano, M, Minici, C, Porcelli, M. | Deposit date: | 2019-07-08 | Release date: | 2020-02-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.336 Å) | Cite: | Structures of catalytic cycle intermediates of the Pyrococcus furiosus methionine adenosyltransferase demonstrate negative cooperativity in the archaeal orthologues. J.Struct.Biol., 210, 2020
|
|
6RMJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6rmj by Molmil](/molmil-images/mine/6rmj) | Crystal structure of human NGR-TNF | Descriptor: | Tumor necrosis factor | Authors: | Degano, M, Garau, G. | Deposit date: | 2019-05-07 | Release date: | 2019-10-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Mechanism of Action of the Tumor Vessel Targeting Agent NGR-hTNF: Role of Both NGR Peptide and hTNF in Cell Binding and Signaling. Int J Mol Sci, 20, 2019
|
|
6ZTD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ztd by Molmil](/molmil-images/mine/6ztd) | Crystal structure of the BCR Fab fragment from subset #169 case P6540 | Descriptor: | Heavy chain of the Fab fragment from BCR derived from the P6540 CLL clone, Light chain of the Fab fragment from BCR derived from the P6540 CLL clone | Authors: | Carriles, A.A, Minici, C, Degano, M. | Deposit date: | 2020-07-18 | Release date: | 2021-05-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.43 Å) | Cite: | Higher-order immunoglobulin repertoire restrictions in CLL: the illustrative case of stereotyped subsets 2 and 169. Blood, 137, 2021
|
|
3B9X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3b9x by Molmil](/molmil-images/mine/3b9x) | |
2CKB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ckb by Molmil](/molmil-images/mine/2ckb) | STRUCTURE OF THE 2C/KB/DEV8 COMPLEX | Descriptor: | ALPHA, BETA T CELL RECEPTOR, BETA-2 MICROGLOBULIN, ... | Authors: | Garcia, K.C, Degano, M, Wilson, I.A. | Deposit date: | 1998-01-14 | Release date: | 1998-04-29 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science, 279, 1998
|
|
5IFH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ifh by Molmil](/molmil-images/mine/5ifh) | Crystal structure of the BCR Fab fragment from subset #2 case P11475 | Descriptor: | Heavy chain of the Fab fragment from BCR derived from the P11475 CLL clone, Light chain of the Fab fragment from BCR derived from the P11475 CLL clone | Authors: | Minici, C, Degano, M. | Deposit date: | 2016-02-26 | Release date: | 2017-03-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.293 Å) | Cite: | Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia. Nat Commun, 8, 2017
|
|
3MKM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mkm by Molmil](/molmil-images/mine/3mkm) | Crystal structure of the E. coli pyrimidine nucleoside hydrolase YeiK (Apo-form) | Descriptor: | CALCIUM ION, Putative uncharacterized protein YeiK | Authors: | Garau, G, Fornili, A, Giabbai, B, Degano, M. | Deposit date: | 2010-04-15 | Release date: | 2010-12-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Energy Landscapes Associated with Macromolecular Conformational Changes from Endpoint Structures J.Am.Chem.Soc., 132, 2010
|
|
1Q8F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1q8f by Molmil](/molmil-images/mine/1q8f) | |
8OIC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8oic by Molmil](/molmil-images/mine/8oic) | Trichomonas vaginalis riboside hydrolase (His-tagged) | Descriptor: | BICINE, CALCIUM ION, Inosine-uridine preferring nucleoside hydrolase family protein | Authors: | Patrone, M, Stockman, B.J, Degano, M. | Deposit date: | 2023-03-22 | Release date: | 2023-08-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis. J.Biol.Chem., 299, 2023
|
|
3G5I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3g5i by Molmil](/molmil-images/mine/3g5i) | Crystal Structure of the E.coli RihA pyrimidine nucleosidase bound to a iminoribitol-based inhibitor | Descriptor: | (2S,3S,4R,5R)-2-(3,4-diaminophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol, BETA-MERCAPTOETHANOL, CALCIUM ION, ... | Authors: | Garau, G, Muzzolini, L, Tornaghi, P, Degano, M. | Deposit date: | 2009-02-05 | Release date: | 2010-02-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Active site plasticity revealed from the structure of the enterobacterial N-ribohydrolase RihA bound to a competitive inhibitor. Bmc Struct.Biol., 10, 2010
|
|
5DRX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5drx by Molmil](/molmil-images/mine/5drx) | |
3MKN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mkn by Molmil](/molmil-images/mine/3mkn) | Crystal structure of the E. coli pyrimidine nucleosidase YeiK bound to a competitive inhibitor | Descriptor: | (2S,3S,4R,5R)-2-(3,4-diaminophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol, CALCIUM ION, Putative uncharacterized protein YeiK | Authors: | Garau, G, Fornili, A, Giabbai, B, Degano, M. | Deposit date: | 2010-04-15 | Release date: | 2010-12-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Energy Landscapes Associated with Macromolecular Conformational Changes from Endpoint Structures J.Am.Chem.Soc., 132, 2010
|
|
5DRW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5drw by Molmil](/molmil-images/mine/5drw) | |
8OI7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8oi7 by Molmil](/molmil-images/mine/8oi7) | Trichomonas vaginalis riboside hydrolase | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Inosine-uridine preferring nucleoside hydrolase family protein, ... | Authors: | Patrone, M, Stockman, B.J, Degano, M. | Deposit date: | 2023-03-22 | Release date: | 2023-08-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis. J.Biol.Chem., 299, 2023
|
|
8OI9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8oi9 by Molmil](/molmil-images/mine/8oi9) | Trichomonas vaginalis riboside hydrolase in complex with 5-methyluridine | Descriptor: | 5-methyluridine, CALCIUM ION, Inosine-uridine preferring nucleoside hydrolase family protein, ... | Authors: | Patrone, M, Stockman, B.J, Degano, M. | Deposit date: | 2023-03-22 | Release date: | 2023-08-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis. J.Biol.Chem., 299, 2023
|
|
8OIA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8oia by Molmil](/molmil-images/mine/8oia) | Trichomonas vaginalis riboside hydrolase in complex with D-ribose | Descriptor: | CALCIUM ION, GLYCEROL, Inosine-uridine preferring nucleoside hydrolase family protein, ... | Authors: | Patrone, M, Stockman, B.J, Degano, M. | Deposit date: | 2023-03-22 | Release date: | 2023-08-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis. J.Biol.Chem., 299, 2023
|
|
8OIB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8oib by Molmil](/molmil-images/mine/8oib) | |
1YOE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yoe by Molmil](/molmil-images/mine/1yoe) | |
3T8I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3t8i by Molmil](/molmil-images/mine/3t8i) | Structural analysis of thermostable S. solfataricus purine-specific nucleoside hydrolase | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Minici, C, Cacciapuoti, G, De Leo, E, Porcelli, M, Degano, M. | Deposit date: | 2011-08-01 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | New Determinants in the Catalytic Mechanism of Nucleoside Hydrolases from the Structures of Two Isozymes from Sulfolobus solfataricus. Biochemistry, 51, 2012
|
|
1ZHN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zhn by Molmil](/molmil-images/mine/1zhn) | Crystal Structure of mouse CD1d bound to the self ligand phosphatidylcholine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-[(DODECANOYLOXY)METHYL]-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-3,5,8-TRIOXA-4-PHOSPHADOTRIACONTAN-1-AMINIUM 4-OXIDE, CD1d1 antigen, ... | Authors: | Giabbai, B, Sidobre, S, Crispin, M.M.D, Sanchez Ruiz, Y, Bachi, A, Kronenberg, M, Wilson, I.A, Degano, M. | Deposit date: | 2005-04-26 | Release date: | 2005-07-19 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation J.Immunol., 175, 2005
|
|