5DRX

Crystal structure of the BCR Fab fragment from subset #4 case CLL240

Summary for 5DRX

Entry DOI	10.2210/pdb5drx/pdb
Descriptor	CLL240 heavy chain (VH and CH1 domains), CLL240 BCR light chain, GLYCEROL, ... (4 entities in total)
Functional Keywords	immunoglobulin fold, b cell receptor, chronic lymphocytic leukemia, immune system, receptor-ligand complex
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	98371.67
Authors	Minici, C.,Degano, M. (deposition date: 2015-09-16, release date: 2016-09-28, Last modification date: 2022-10-26)
Primary citation	Minici, C.,Gounari, M.,Ubelhart, R.,Scarfo, L.,Duhren-von Minden, M.,Schneider, D.,Tasdogan, A.,Alkhatib, A.,Agathangelidis, A.,Ntoufa, S.,Chiorazzi, N.,Jumaa, H.,Stamatopoulos, K.,Ghia, P.,Degano, M. Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia. Nat Commun, 8:15746-15746, 2017 Cited by PubMed: 28598442 DOI: 10.1038/ncomms15746 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.104 Å)

Structure validation