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PDB: 21 件
3EL7
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BU of 3el7 by Molmil
Crystal structure of c-Src in complex with pyrazolopyrimidine 3
分子名称: 1-{3-[(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea, Proto-oncogene tyrosine-protein kinase Src
著者Dar, A.C, Lopez, M.S, Shokat, K.M.
登録日2008-09-20
公開日2008-10-28
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Small molecule recognition of c-Src via the Imatinib-binding conformation.
Chem.Biol., 15, 2008
3EL8
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BU of 3el8 by Molmil
Crystal structure of c-Src in complex with pyrazolopyrimidine 5
分子名称: 1-{4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea, Proto-oncogene tyrosine-protein kinase Src
著者Dar, A.C, Lopez, M.S, Shokat, K.M.
登録日2008-09-20
公開日2008-10-28
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Small molecule recognition of c-Src via the Imatinib-binding conformation.
Chem.Biol., 15, 2008
2A19
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BU of 2a19 by Molmil
PKR kinase domain- eIF2alpha- AMP-PNP complex.
分子名称: Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase, ...
著者Dar, A.C, Dever, T.E, Sicheri, F.
登録日2005-06-19
公開日2005-09-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR.
Cell(Cambridge,Mass.), 122, 2005
2A1A
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BU of 2a1a by Molmil
PKR kinase domain-eIF2alpha Complex
分子名称: Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase
著者Dar, A.C, Dever, T.E, Sicheri, F.
登録日2005-06-19
公開日2005-09-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR.
Cell(Cambridge,Mass.), 122, 2005
1LUZ
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BU of 1luz by Molmil
Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)
分子名称: Protein K3
著者Dar, A.C, Sicheri, F.
登録日2002-05-23
公開日2002-08-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition.
Mol.Cell, 10, 2002
5KKR
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BU of 5kkr by Molmil
KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79
分子名称: 6,7-dimethoxy-~{N}-(2-methyl-4-phenoxy-phenyl)quinazolin-4-amine, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2
著者Dhawan, N.S, Scopton, A.P, Dar, A.C.
登録日2016-06-22
公開日2016-08-31
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.509 Å)
主引用文献Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling.
Nature, 537, 2016
7UMB
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BU of 7umb by Molmil
NanoBRET tracer Tram-bo bound to a KSR2-MEK1 complex
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Marsiglia, W.M, Khan, K.M, Dar, A.C.
登録日2022-04-06
公開日2023-09-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.231 Å)
主引用文献Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes.
Nat.Chem.Biol., 20, 2024
4LGH
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BU of 4lgh by Molmil
Crystal structure of 1NM-PP1 bound to analog-sensitive Src kinase
分子名称: 1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
著者Lopez, M.S, Dar, A.C, Shokat, K.M.
登録日2013-06-27
公開日2013-08-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.
Acs Chem.Biol., 8, 2013
4LGG
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BU of 4lgg by Molmil
Structure of 3MB-PP1 bound to analog-sensitive Src kinase
分子名称: 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
著者Lopez, M.S, Dar, A.C, Shokat, K.M.
登録日2013-06-27
公開日2013-08-07
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.
Acs Chem.Biol., 8, 2013
7JUQ
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BU of 7juq by Molmil
Crystal Structure of KSR2:MEK1 in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUR
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BU of 7jur by Molmil
Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUX
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BU of 7jux by Molmil
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.34 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUV
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BU of 7juv by Molmil
Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C, Scopton, A.P.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.36 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUT
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BU of 7jut by Molmil
Crystal Structure of KSR2:MEK1 in complex with ANP-PNP, and allosteric MEK inhibitor Selumetinib
分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.09 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUS
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BU of 7jus by Molmil
Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib
分子名称: Cobimetinib, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JV0
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BU of 7jv0 by Molmil
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.63 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUW
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BU of 7juw by Molmil
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JV1
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BU of 7jv1 by Molmil
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C, Scopton, A.P.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.62 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUZ
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BU of 7juz by Molmil
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Selumetinib
分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUU
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BU of 7juu by Molmil
Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUY
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BU of 7juy by Molmil
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-10-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.096 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020

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件を2024-07-24に公開中

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