2DHN
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![BU of 2dhn by Molmil](/molmil-images/mine/2dhn) | COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION | Descriptor: | 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 7,8-DIHYDRONEOPTERIN ALDOLASE | Authors: | Hennig, M, D'Arcy, A, Hampele, I.C, Page, M.G.P, Oefner, C.H, Dale, G. | Deposit date: | 1998-03-31 | Release date: | 1999-04-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus. Nat.Struct.Biol., 5, 1998
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1CBK
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![BU of 1cbk by Molmil](/molmil-images/mine/1cbk) | 7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE FROM HAEMOPHILUS INFLUENZAE | Descriptor: | 7,8-DIHYDRO-7,7-DIMETHYL-6-HYDROXYPTERIN, PROTEIN (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE), SULFATE ION | Authors: | Hennig, M, D'Arcy, A, Dale, G, Oefner, C. | Deposit date: | 1999-02-26 | Release date: | 2000-03-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae. J.Mol.Biol., 287, 1999
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1Y8J
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![BU of 1y8j by Molmil](/molmil-images/mine/1y8j) | Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor | Descriptor: | 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | Authors: | Sahli, S, Frank, B, Schweizer, W.B, Diederich, F, Blum-Kaelin, D, Aebi, J.D, Bohm, H.J, Oefner, C, Dale, G.E. | Deposit date: | 2004-12-13 | Release date: | 2005-06-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Second-Generation Inhibitors for the Metalloprotease Neprilysin Based on Bicyclic Heteroaromatic Scaffolds: Synthesis, Biological Activity, and X-ray Crystal Structure Analysis HELV.CHIM.ACTA, 88, 2005
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2QPJ
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![BU of 2qpj by Molmil](/molmil-images/mine/2qpj) | Human NEP complexed with a bifunctional NEP/DPP IV inhibitor | Descriptor: | (2S)-2-({(2S)-3-[(R)-[(1R)-1-({(4S)-4-amino-5-[(2S)-2-cyanopyrrolidin-1-yl]-5-oxopentanoyl}amino)ethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}amino)propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Neprilysin, ... | Authors: | Oefner, C, Dale, G.E. | Deposit date: | 2007-07-24 | Release date: | 2007-11-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV. Acta Crystallogr.,Sect.D, 63, 2007
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1F97
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![BU of 1f97 by Molmil](/molmil-images/mine/1f97) | SOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSE | Descriptor: | JUNCTION ADHESION MOLECULE, MAGNESIUM ION | Authors: | Kostrewa, D, Brockhaus, M, D'Arcy, A, Dale, G, Bazzoni, G, Dejana, E, Winkler, F, Hennig, M. | Deposit date: | 2000-07-07 | Release date: | 2001-01-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif. EMBO J., 20, 2001
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1DHN
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![BU of 1dhn by Molmil](/molmil-images/mine/1dhn) | 1.65 ANGSTROM RESOLUTION STRUCTURE OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS | Descriptor: | 7,8-DIHYDRONEOPTERIN ALDOLASE | Authors: | Hennig, M, D'Arcy, A, Hampele, I.C, Page, M.G.P, Oefner, C.H, Dale, G. | Deposit date: | 1998-03-31 | Release date: | 1999-04-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus. Nat.Struct.Biol., 5, 1998
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1PFQ
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![BU of 1pfq by Molmil](/molmil-images/mine/1pfq) | crystal structure of human apo dipeptidyl peptidase IV / CD26 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase IV soluble form | Authors: | Oefner, C, D'Arcy, A, Mac Sweeney, A, Pierau, S, Gardiner, R, Dale, G.E. | Deposit date: | 2003-05-27 | Release date: | 2003-07-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine. Acta Crystallogr.,Sect.D, 59, 2003
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1DMT
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![BU of 1dmt by Molmil](/molmil-images/mine/1dmt) | STRUCTURE OF HUMAN NEUTRAL ENDOPEPTIDASE COMPLEXED WITH PHOSPHORAMIDON | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN, ... | Authors: | Oefner, C, D'Arcy, A, Hennig, M, Winkler, F.K, Dale, G.E. | Deposit date: | 1999-12-15 | Release date: | 2000-12-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon. J.Mol.Biol., 296, 2000
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1QXW
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![BU of 1qxw by Molmil](/molmil-images/mine/1qxw) | Crystal structure of Staphyloccocus aureus in complex with an aminoketone inhibitor 54135. | Descriptor: | (3S)-3-AMINO-1-(CYCLOPROPYLAMINO)HEPTANE-2,2-DIOL, ACETATE ION, COBALT (II) ION, ... | Authors: | Douangamath, A, Dale, G.E, D'Arcy, A, Oefner, C. | Deposit date: | 2003-09-09 | Release date: | 2004-03-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate. J.Med.Chem., 47, 2004
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1QXY
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![BU of 1qxy by Molmil](/molmil-images/mine/1qxy) | Crystal structure of S. aureus methionine aminopeptidase in complex with a ketoheterocycle 618 | Descriptor: | (2S)-2-AMINO-4-(METHYLSULFANYL)-1-PYRIDIN-2-YLBUTANE-1,1-DIOL, ACETATE ION, COBALT (II) ION, ... | Authors: | Douangamath, A, Dale, G.E, D'Arcy, A, Oefner, C. | Deposit date: | 2003-09-09 | Release date: | 2004-03-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate. J.Med.Chem., 47, 2004
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1R1I
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![BU of 1r1i by Molmil](/molmil-images/mine/1r1i) | STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Neprilysin, ZINC ION, ... | Authors: | Oefner, C, Roques, B.P, Fournie-Zaluski, M.C, Dale, G.E. | Deposit date: | 2003-09-24 | Release date: | 2004-09-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural analysis of neprilysin with various specific and potent inhibitors. Acta Crystallogr.,Sect.D, 60, 2004
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1R1H
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![BU of 1r1h by Molmil](/molmil-images/mine/1r1h) | STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[3-[(1-AMINOETHYL)(HYDROXY)PHOSPHORYL]-2-(1,1'-BIPHENYL-4-YLMETHYL)PROPANOYL]ALANINE, Neprilysin, ... | Authors: | Oefner, C, Roques, B.P, Fournie-Zaluski, M.C, Dale, G.E. | Deposit date: | 2003-09-24 | Release date: | 2004-09-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural analysis of neprilysin with various specific and potent inhibitors. Acta Crystallogr.,Sect.D, 60, 2004
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1R1J
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![BU of 1r1j by Molmil](/molmil-images/mine/1r1j) | STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, N-(3-PHENYL-2-SULFANYLPROPANOYL)PHENYLALANYLALANINE, Neprilysin, ... | Authors: | Oefner, C, Roques, B.P, Fournie-Zaluski, M.C, Dale, G.E. | Deposit date: | 2003-09-24 | Release date: | 2004-09-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural analysis of neprilysin with various specific and potent inhibitors. Acta Crystallogr.,Sect.D, 60, 2004
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1QXZ
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![BU of 1qxz by Molmil](/molmil-images/mine/1qxz) | Crystal structure of S. aureus methionine aminopeptidase in complex with a ketoheterocycle inhibitor 119 | Descriptor: | (2S)-2-AMINO-4-(METHYLSULFANYL)-1-(1,3-THIAZOL-2-YL)BUTANE-1,1-DIOL, COBALT (II) ION, methionyl aminopeptidase | Authors: | Douangamath, A, Dale, G.E, D'Arcy, A, Oefner, C. | Deposit date: | 2003-09-09 | Release date: | 2004-03-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate. J.Med.Chem., 47, 2004
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3FY8
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![BU of 3fy8 by Molmil](/molmil-images/mine/3fy8) | Crystal Structure of Staph. aureus DHFR complexed with NADPH and AR-101 | Descriptor: | 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Oefner, C, Dale, G.E. | Deposit date: | 2009-01-22 | Release date: | 2009-08-04 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus Acta Crystallogr.,Sect.D, 65, 2009
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4GNY
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![BU of 4gny by Molmil](/molmil-images/mine/4gny) | Bovine beta-lactoglobulin complex with dodecyl sulfate | Descriptor: | Beta-lactoglobulin, DODECYL SULFATE, GLYCEROL | Authors: | Gutierrez-Magdaleno, G, Torres-Rivera, A, Garcia-Hernandez, E, Rodriguez-Romero, A. | Deposit date: | 2012-08-17 | Release date: | 2013-02-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.6367 Å) | Cite: | Ligand-binding and self-association cooperativity of beta-lactoglobulin J.Mol.Recognit., 26, 2013
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2OQX
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![BU of 2oqx by Molmil](/molmil-images/mine/2oqx) | Crystal Structure of the apo form of E. coli tryptophanase at 1.9 A resolution | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Goldgur, Y, Kogan, A, Gdalevsky, G, Parola, A, Cohen-Luria, R, Almog, O. | Deposit date: | 2007-02-01 | Release date: | 2007-02-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structure of apo tryptophanase from Escherichia coli reveals a wide-open conformation. Acta Crystallogr.,Sect.D, 63, 2007
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3DQW
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![BU of 3dqw by Molmil](/molmil-images/mine/3dqw) | c-Src kinase domain Thr338Ile mutant in complex with ATPgS | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Proto-oncogene tyrosine-protein kinase Src | Authors: | Azam, M, Seeliger, M.A, Gray, N, Kuriyan, J, Daley, G.Q. | Deposit date: | 2008-07-09 | Release date: | 2008-09-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.017 Å) | Cite: | Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat.Struct.Mol.Biol., 15, 2008
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3DQX
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![BU of 3dqx by Molmil](/molmil-images/mine/3dqx) | chicken c-Src kinase domain in complex with ATPgS | Descriptor: | ADENOSINE MONOPHOSPHATE, Proto-oncogene tyrosine-protein kinase Src | Authors: | Azam, M, Seeliger, M.A, Gray, N, Kuriyan, J, Daley, G.Q. | Deposit date: | 2008-07-09 | Release date: | 2008-09-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat.Struct.Mol.Biol., 15, 2008
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2V0Y
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![BU of 2v0y by Molmil](/molmil-images/mine/2v0y) | Crystal structure of apo C298S tryptophanase from E.coli | Descriptor: | CHLORIDE ION, MAGNESIUM ION, TRYPTOPHANASE | Authors: | Kogan, A, Gdalevsky, G.Y, Cohen-Luria, R, Goldgur, Y, Parola, A.H, Almog, O. | Deposit date: | 2007-05-21 | Release date: | 2008-06-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformational Changes and Loose Packing Promote E. Coli Tryptophanase Cold Lability. Bmc Struct.Biol., 9, 2009
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2V1P
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![BU of 2v1p by Molmil](/molmil-images/mine/2v1p) | Crystal Structure of the apo form of Y74F mutant E. coli tryptophanase | Descriptor: | CHLORIDE ION, MAGNESIUM ION, TRYPTHOPANASE | Authors: | Kogan, A, Gdalevsky, G.Y, Cohen-Luria, R, Goldgur, Y, Parola, A.H, Almog, O. | Deposit date: | 2007-05-28 | Release date: | 2008-06-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Conformational Changes and Loose Packing Promote E. Coli Tryptophanase Cold Lability. Bmc Struct.Biol., 9, 2009
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