2QPJ
Human NEP complexed with a bifunctional NEP/DPP IV inhibitor
Summary for 2QPJ
| Entry DOI | 10.2210/pdb2qpj/pdb |
| Descriptor | Neprilysin, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total) |
| Functional Keywords | zinc-dependent metalloprotease, glycoprotein, hydrolase, membrane, metal-binding, signal-anchor, transmembrane, lt3_9 |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane; Single-pass type II membrane protein: P08473 |
| Total number of polymer chains | 1 |
| Total formula weight | 80804.10 |
| Authors | Oefner, C.,Dale, G.E. (deposition date: 2007-07-24, release date: 2007-11-27, Last modification date: 2023-08-30) |
| Primary citation | Oefner, C.,Pierau, S.,Schulz, H.,Dale, G.E. Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV. Acta Crystallogr.,Sect.D, 63:975-981, 2007 Cited by PubMed: 17704566DOI: 10.1107/S0907444907036281 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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