2QPJ
Human NEP complexed with a bifunctional NEP/DPP IV inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Neprilysin | polymer | 696 | 79525.5 | 1 | UniProt (P08473) Pfam (PF05649) Pfam (PF01431) | Homo sapiens (human) | Neutral endopeptidase, NEP, Enkephalinase, Neutral endopeptidase 24.11, Atriopeptidase, Common acute lymphocytic leukemia antigen, CALLA, CD10 antigen |
| 2 | B, C, D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 3 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | F (A) | (2S)-2-({(2S)-3-[(R)-[(1R)-1-({(4S)-4-amino-5-[(2S)-2-cyanopyrrolidin-1-yl]-5-oxopentanoyl}amino)ethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}amino)propanoic acid | non-polymer | 549.6 | 1 | Chemie (I20) | |||
| 5 | G (A) | water | water | 18.0 | 291 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 79525.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1278.6 | |
| All* | Total formula weight | 80804.1 |
