3A3W
| Structure of OpdA mutant (G60A/A80V/S92A/R118Q/K185R/Q206P/D208G/I260T/G273S) with diethyl 4-methoxyphenyl phosphate bound in the active site | 分子名称: | COBALT (II) ION, DIETHYL 4-METHOXYPHENYL PHOSPHATE, Phosphotriesterase | 著者 | Ollis, D.L, Tawfik, D.S, Schenk, G, Jackson, C.J, Foo, J.L, Tokuriki, N, Afriat, L, Carr, P.D, Kim, H.K. | 登録日 | 2009-06-23 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase Proc.Natl.Acad.Sci.USA, 2009
|
|
2ZOA
| Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) COLLECTED AT 1.280 ANGSTROM | 分子名称: | FE (II) ION, MALONATE ION, Phosphohydrolase | 著者 | Ollis, D.L, Jackson, C.J, Carr, P.D. | 登録日 | 2008-05-07 | 公開日 | 2008-10-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference. Acta Crystallogr.,Sect.F, 64, 2008
|
|
3A60
| Crystal structure of unphosphorylated p70S6K1 (Form I) | 分子名称: | Ribosomal protein S6 kinase beta-1, STAUROSPORINE | 著者 | Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. | 登録日 | 2009-08-17 | 公開日 | 2009-10-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
|
|
3A4J
| arPTE (K185R/D208G/N265D/T274N) | 分子名称: | 1,2-ETHANEDIOL, COBALT (II) ION, Phosphotriesterase | 著者 | Foo, J.L, Jackson, C.J, Carr, P.D, Ollis, D.L. | 登録日 | 2009-07-07 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase Proc.Natl.Acad.Sci.USA, 2009
|
|
3A61
| Crystal structure of unphosphorylated p70S6K1 (Form II) | 分子名称: | Ribosomal protein S6 kinase beta-1, STAUROSPORINE | 著者 | Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. | 登録日 | 2009-08-18 | 公開日 | 2009-10-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.43 Å) | 主引用文献 | Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
|
|
3A62
| Crystal structure of phosphorylated p70S6K1 | 分子名称: | MANGANESE (II) ION, Ribosomal protein S6 kinase beta-1, STAUROSPORINE | 著者 | Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. | 登録日 | 2009-08-18 | 公開日 | 2009-10-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
|
|
3A3X
| Structure of OpdA mutant (G60A/A80V/R118Q/K185R/Q206P/D208G/I260T/G273S) | 分子名称: | COBALT (II) ION, Phosphotriesterase | 著者 | Ollis, D.L, Tawfik, D.S, Schenk, G, Jackson, C.J, Foo, J.L, Tokuriki, N, Afriat, L, Carr, P.D, Kim, H.K. | 登録日 | 2009-06-23 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase Proc.Natl.Acad.Sci.USA, 2009
|
|
3C86
| OpdA from agrobacterium radiobacter with bound product diethyl thiophosphate from crystal soaking with tetraethyl dithiopyrophosphate- 1.8 A | 分子名称: | 1,2-ETHANEDIOL, COBALT (II) ION, FE (II) ION, ... | 著者 | Ollis, D.L, Jackson, C.J, Foo, J.L, Kim, H.K, Carr, P.D, Liu, J.W, Salem, G. | 登録日 | 2008-02-10 | 公開日 | 2008-02-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase J.Mol.Biol., 375, 2008
|
|
6EIT
| |
6ESB
| |
6EDG
| Pseudomonas exotoxin A domain III T18H477L | 分子名称: | Exotoxin, N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE | 著者 | Moss, D.L, Park, H.W, Mettu, R.R, Landry, S.J. | 登録日 | 2018-08-09 | 公開日 | 2019-02-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Deimmunizing substitutions in Pseudomonasexotoxin domain III perturb antigen processing without eliminating T-cell epitopes. J.Biol.Chem., 294, 2019
|
|
2BPN
| SOLUTION STRUCTURE OF DESULFOVIBRIO VULGARIS (HILDENBOROUGH) FERRICYTOCHROME C3, NMR, 20 STRUCTURES | 分子名称: | CYTOCHROME C3, HEME C | 著者 | Messias, A.C, Aguiar, A.P, Brennan, L, Xavier, A.V, Turner, D.L. | 登録日 | 2005-04-21 | 公開日 | 2006-03-15 | 最終更新日 | 2011-07-13 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structures of Tetrahaem Ferricytochrome C(3) from Desulfovibrio Vulgaris (Hildenborough) and its K45Q Mutant: The Molecular Basis of Cooperativity. Biochim.Biophys.Acta, 1757, 2006
|
|
6EZM
| Imidazoleglycerol-phosphate dehydratase from Saccharomyces cerevisiae | 分子名称: | Imidazoleglycerol-phosphate dehydratase, MANGANESE (II) ION, [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid | 著者 | Rawson, S, Bisson, C, Hurdiss, D.L, Muench, S.P. | 登録日 | 2017-11-15 | 公開日 | 2018-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
6EZJ
| Imidazoleglycerol-phosphate dehydratase | 分子名称: | Imidazoleglycerol-phosphate dehydratase 2, chloroplastic, MANGANESE (II) ION, ... | 著者 | Rawson, S, Bisson, C, Hurdiss, D.L, Muench, S.P. | 登録日 | 2017-11-15 | 公開日 | 2018-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
6FP4
| Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 1,8-Naphthyridine-2-carboxylic acid | 分子名称: | (2R)-2-hydroxy-3-[4-(2-hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid, 1,8-naphthyridine-2-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Silvestri, I, Fata, F, MIele, A.E, Boumis, G, Williams, D.L, Angelucci, F. | 登録日 | 2018-02-09 | 公開日 | 2018-06-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. ACS Chem. Biol., 13, 2018
|
|
2DXN
| |
6FMU
| Thioredoxin glutathione reductase from Schistosome mansoni in complex with 2-[4-(4-amino-butyl)-piperazin-1-yl]-ethanol | 分子名称: | 2-[4-(4-azanylbutyl)piperazin-1-yl]ethanol, FLAVIN-ADENINE DINUCLEOTIDE, TRIETHYLENE GLYCOL, ... | 著者 | Silvestri, I, Fata, F, MIele, A.E, Boumis, G, Williams, D.L, Angelucci, F. | 登録日 | 2018-02-02 | 公開日 | 2018-06-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. ACS Chem. Biol., 13, 2018
|
|
6FTC
| Thioredoxin glutathione reductase from Schistosoma mansoni in complex with HEPES | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Silvestri, I, Fata, F, MIele, A.E, Boumis, G, Williams, D.L, Angelucci, F. | 登録日 | 2018-02-21 | 公開日 | 2018-06-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. ACS Chem. Biol., 13, 2018
|
|
6FMZ
| Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 1,4-Bis(2-hydroxyethyl)piperazine | 分子名称: | 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanol, FLAVIN-ADENINE DINUCLEOTIDE, Thioredoxin glutathione reductase | 著者 | Silvestri, I, Fata, F, MIele, A.E, Boumis, G, Williams, D.L, Angelucci, F. | 登録日 | 2018-02-02 | 公開日 | 2018-06-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. ACS Chem. Biol., 13, 2018
|
|
2DXL
| |
2EIA
| |
1MCH
| PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS | 分子名称: | IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN), PEPTIDE N-ACETYL-L-GLN-D-PHE-L-HIS-D-PRO-B-ALA-B-ALA-OH | 著者 | Edmundson, A.B, Harris, D.L, Fan, Z.-C, Guddat, L.W. | 登録日 | 1993-02-25 | 公開日 | 1994-01-31 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Principles and pitfalls in designing site-directed peptide ligands. Proteins, 16, 1993
|
|
1MCQ
| PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS | 分子名称: | IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN), PEPTIDE N-ACETYL-L-HIS-D-PRO-NH2 | 著者 | Edmundson, A.B, Harris, D.L, Fan, Z.-C, Guddat, L.W. | 登録日 | 1993-02-25 | 公開日 | 1994-01-31 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Principles and pitfalls in designing site-directed peptide ligands. Proteins, 16, 1993
|
|
1MEJ
| Human Glycinamide Ribonucleotide Transformylase domain at pH 8.5 | 分子名称: | GLYCEROL, PHOSPHATE ION, Phosphoribosylglycinamide formyltransferase | 著者 | Zhang, Y, Desharnais, J, Greasley, S.E, Beardsley, G.P, Boger, D.L, Wilson, I.A. | 登録日 | 2002-08-08 | 公開日 | 2002-12-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of human GAR Tfase of low and high pH and with substrate beta-GAR Biochemistry, 41, 2002
|
|
1MCB
| PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS | 分子名称: | IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN), PEPTIDE N-ACETYL-L-GLN-D-PHE-L-HIS-D-PRO-OH | 著者 | Edmundson, A.B, Harris, D.L, Fan, Z.-C, Guddat, L.W. | 登録日 | 1993-02-25 | 公開日 | 1994-01-31 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Principles and pitfalls in designing site-directed peptide ligands. Proteins, 16, 1993
|
|