4DLA
 
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4GJH
 | | Crystal Structure of the TRAF domain of TRAF5 | | Descriptor: | TNF receptor-associated factor 5 | | Authors: | Zhang, P, Reichardt, A, Liang, H, Wang, Y, Cheng, D, Aliyari, R, Cheng, G, Liu, Y. | | Deposit date: | 2012-08-09 | | Release date: | 2012-11-28 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.805 Å) | | Cite: | Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5
Sci.Signal., 5, 2012
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4DSN
 | | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | | Descriptor: | 1,2-ETHANEDIOL, GTPase KRas, isoform 2B, ... | | Authors: | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | | Deposit date: | 2012-02-19 | | Release date: | 2012-04-25 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4GKG
 | | Crystal structure of the S-Helix Linker | | Descriptor: | C4-dicarboxylate transport sensor protein dctB, PHOSPHATE ION | | Authors: | Liu, J.W, Lu, D, Sun, Y.J, Wen, J, Yang, Y, Yang, J.G, Wei, X.L, Zhang, X.D, Wang, Y.P. | | Deposit date: | 2012-08-11 | | Release date: | 2013-08-28 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.695 Å) | | Cite: | Crystal structure of the S-Helix Linker
To be Published
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4DNW
 | | Crystal structure of UVB-resistance protein UVR8 | | Descriptor: | AT5g63860/MGI19_6 | | Authors: | Wu, D, Hu, Q, Yan, Z, Chen, W, Yan, C, Wang, J, Shi, Y. | | Deposit date: | 2012-02-09 | | Release date: | 2012-03-07 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.773 Å) | | Cite: | Structural basis of ultraviolet-B perception by UVR8.
Nature, 484, 2012
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4GLH
 | | DNA dodecamer containing 5-hydroxymethyl cytosine | | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(5HC)P*GP*CP*G)-3'), POTASSIUM ION | | Authors: | Spingler, B, Renciuk, D, Vorlickova, M. | | Deposit date: | 2012-08-14 | | Release date: | 2013-08-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.662 Å) | | Cite: | Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine.
Nucleic Acids Res., 41, 2013
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4DOG
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4BK4
 | | crystal structure of the human EphA4 ectodomain | | Descriptor: | EPHRIN TYPE-A RECEPTOR 4 | | Authors: | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | | Deposit date: | 2013-04-22 | | Release date: | 2013-07-03 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.65 Å) | | Cite: | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses
Nat.Struct.Mol.Biol., 20, 2013
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4BLF
 | | Variable internal flexibility characterizes the helical capsid formed by Agrobacterium VirE2 protein on single-stranded DNA. | | Descriptor: | SINGLE-STRAND DNA-BINDING PROTEIN | | Authors: | Bharat, T.A.M, Zbaida, D, Eisenstein, M, Frankenstein, Z, Mehlman, T, Weiner, L, Sorzano, C.O.S, Barak, Y, Albeck, S, Briggs, J.A.G, Wolf, S.G, Elbaum, M. | | Deposit date: | 2013-05-02 | | Release date: | 2013-06-26 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (20 Å) | | Cite: | Variable Internal Flexibility Characterizes the Helical Capsid Formed by Agrobacterium Vire2 Protein on Single-Stranded DNA.
Structure, 21, 2013
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4BLP
 | | P4 PROTEIN FROM BACTERIOPHAGE PHI13 | | Descriptor: | CITRATE ANION, GLYCEROL, PACKAGING ENZYME P4 | | Authors: | El Omari, K, Meier, C, Kainov, D, Sutton, G, Grimes, J.M, Poranen, M.M, Bamford, D.H, Tuma, R, Stuart, D.I, Mancini, E.J. | | Deposit date: | 2013-05-04 | | Release date: | 2013-08-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Tracking in Atomic Detail the Functional Specializations in Viral Reca Helicases that Occur During Evolution.
Nucleic Acids Res., 41, 2013
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4BEA
 | | Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative | | Descriptor: | Eukaryotic translation initiation factor 4E, STAPLED EIF4E INTERACTING PEPTIDE | | Authors: | Quah, S.T, Lama, D, Verma, C.S, Lane, D.P, Brown, C.J. | | Deposit date: | 2013-03-07 | | Release date: | 2013-12-11 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Rational Optimization of Conformational Effects Induced by Hydrocarbon Staples in Peptides and Their Binding Interfaces.
Sci.Rep., 3, 2013
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4BIT
 | | solution structure of cerebral dopamine neurotrophic factor (CDNF) | | Descriptor: | CEREBRAL DOPAMINE NEUROTROPHIC FACTOR | | Authors: | Latge, C, Cabral, K.M.S, Raymundo, D.P, Foguel, D, Herrmann, T, Almeida, M.S. | | Deposit date: | 2013-04-13 | | Release date: | 2014-04-23 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | The Solution Structure and Dynamics of Full-Length Human Cerebral Dopamine Neurotrophic Factor and its Neuroprotective Role Against Alpha-Synuclein Oligomers.
J.Biol.Chem., 290, 2015
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4H4P
 | | Crystal Structure of Ferredoxin reductase, BphA4 E175Q/Q177K mutant (oxidized form) | | Descriptor: | Biphenyl dioxygenase ferredoxin reductase subunit, FLAVIN-ADENINE DINUCLEOTIDE, FORMIC ACID, ... | | Authors: | Nishizawa, A, Harada, A, Senda, M, Tachihara, Y, Muramatsu, D, Kishigami, S, Mori, S, Sugiyama, K, Senda, T, Kimura, S. | | Deposit date: | 2012-09-18 | | Release date: | 2013-10-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.502 Å) | | Cite: | Random Mutagenesis with the Project Assessment for Complete Conversion of Co-Factor Specificity of a Ferredoxin Reductase BphA4
To be Published
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4H4X
 | | Crystal Structure of Ferredoxin reductase, BphA4 E175A/T176R/Q177G mutant (oxidized form) | | Descriptor: | Biphenyl dioxygenase ferredoxin reductase subunit, FLAVIN-ADENINE DINUCLEOTIDE, FORMIC ACID, ... | | Authors: | Nishizawa, A, Harada, A, Senda, M, Tachihara, Y, Muramatsu, D, Kishigami, S, Mori, S, Sugiyama, K, Senda, T, Kimura, S. | | Deposit date: | 2012-09-18 | | Release date: | 2013-10-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Random Mutagenesis with the Project Assessment for Complete Conversion of Co-Factor Specificity of a Ferredoxin Reductase BphA4
To be Published
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4AU5
 | | Structure of the NhaA dimer, crystallised at low pH | | Descriptor: | DODECYL-ALPHA-D-MALTOSIDE, NA(+)/H(+) ANTIPORTER NHAA, SULFATE ION | | Authors: | Drew, D, Lee, C, Iwata, S, Cameron, A.D. | | Deposit date: | 2012-05-14 | | Release date: | 2013-07-10 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.696 Å) | | Cite: | Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights.
J. Gen. Physiol., 144, 2014
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4AWL
 | | The NF-Y transcription factor is structurally and functionally a sequence specific histone | | Descriptor: | HSP70 PROMOTER FRAGMENT, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT ALPHA, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA, ... | | Authors: | Nardini, M, Gnesutta, N, Donati, G, Gatta, R, Forni, C, Fossati, A, Vonrhein, C, Moras, D, Romier, C, Mantovani, R, Bolognesi, M. | | Deposit date: | 2012-06-04 | | Release date: | 2013-01-30 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.08 Å) | | Cite: | Sequence-Specific Transcription Factor NF-Y Displays Histone-Like DNA Binding and H2B-Like Ubiquitination.
Cell(Cambridge,Mass.), 152, 2013
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4AZP
 | | Murine epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid anandamide | | Descriptor: | CHLORIDE ION, FATTY ACID-BINDING PROTEIN, EPIDERMAL, ... | | Authors: | Sanson, B, Wang, T, Sun, J, Kaczocha, M, Ojima, I, Deutsch, D, Li, H. | | Deposit date: | 2012-06-26 | | Release date: | 2013-08-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystallographic Study of Fabp5 as an Intracellular Endocannabinoid Transporter.
Acta Crystallogr.,Sect.D, 70, 2014
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4AYM
 | | Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 P106A mutant | | Descriptor: | COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN | | Authors: | Johnson, S, Tan, L, van der Veen, S, Caesar, J, Goicoechea De Jorge, E, Everett, R.J, Bai, X, Exley, R.M, Ward, P.N, Ruivo, N, Trivedi, K, Cumber, E, Jones, R, Newham, L, Staunton, D, Borrow, R, Pickering, M, Lea, S.M, Tang, C.M. | | Deposit date: | 2012-06-21 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
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4AZR
 | | Human epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid anandamide | | Descriptor: | CHLORIDE ION, FATTY ACID-BINDING PROTEIN, EPIDERMAL, ... | | Authors: | Sanson, B, Wang, T, Sun, J, Kaczocha, M, Ojima, I, Deutsch, D, Li, H. | | Deposit date: | 2012-06-26 | | Release date: | 2013-08-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Crystallographic Study of Fabp5 as an Intracellular Endocannabinoid Transporter.
Acta Crystallogr.,Sect.D, 70, 2014
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4B54
 | | The Structure of the inactive mutant G153R of LptC from E. coli | | Descriptor: | ACETATE ION, LIPOPOLYSACCHARIDE EXPORT SYSTEM PROTEIN LPTC | | Authors: | Villa, R, Martorana, A.M, Sperandeo, P, Kahne, D, Okuda, S, Gourlay, L.J, Nardini, M, Bolognesi, M, Polissi, A. | | Deposit date: | 2012-08-02 | | Release date: | 2013-01-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The Escherichia Coli Lpt Transenvelope Protein Complex for Lipopolysaccharide Export is Assembled Via Conserved Structurally Homologous Domains.
J.Bacteriol., 195, 2013
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4BCD
 | | PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor | | Descriptor: | 1-[(2S,4S)-4-[4-(4-fluorophenyl)-1,2,3-triazol-1-yl]-2-pyrrolidin-1-ylcarbonyl-pyrrolidin-1-yl]-4-phenyl-butan-1-one, GLYCEROL, PROLYL ENDOPEPTIDASE, ... | | Authors: | VanDerVeken, P, Fulop, V, Rea, D, Gerard, M, VanElzen, R, Joossens, J, Cheng, J.D, Baekelandt, V, DeMeester, I, Lambeir, A.M, Augustyns, K. | | Deposit date: | 2012-10-01 | | Release date: | 2013-03-13 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy.
J.Med.Chem., 55, 2012
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4BEN
 | | R39-imipenem Acyl-enzyme crystal structure | | Descriptor: | (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, ... | | Authors: | Van Elder, D, Sauvage, E, Herman, R, Kerff, F, Rocaboy, M, Charlier, P. | | Deposit date: | 2013-03-11 | | Release date: | 2013-03-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal Structures of R39-Imipenem Acyl-Enzyme.
To be Published
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4ASJ
 | | Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor | | Descriptor: | CHLORIDE ION, GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide, ... | | Authors: | Alphey, M.S, Pirrie, L, Torrie, L.S, Gardiner, M, Westwood, N.J, Gray, D, Naismith, J.H. | | Deposit date: | 2012-05-01 | | Release date: | 2012-10-31 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
ACS Chem. Biol., 8, 2013
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4AX4
 | | PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, H680A MUTANT | | Descriptor: | GLYCEROL, PROLYL OLIGOPEPTIDASE | | Authors: | Szeltner, Z, Juhasz, T, Szamosi, I, Rea, D, Fulop, V, Modos, K, Juliano, L, Polgar, L. | | Deposit date: | 2012-06-08 | | Release date: | 2012-09-26 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The Loops Facing the Active Site of Prolyl Oligopeptidase are Crucial Components in Substrate Gating and Specificity.
Biochim.Biophys.Acta, 1834, 2012
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4BCB
 | | PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2- substituted N-acyl-prolylpyrrolidine inhibitor | | Descriptor: | (5R,6R,8S)-8-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-5-CYCLOHEXYL-6-HYDROXY-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC ACID 6-OXIDE, GLYCEROL, PROLYL ENDOPEPTIDASE, ... | | Authors: | VanDerVeken, P, Fulop, V, Rea, D, Gerard, M, VanElzen, R, Joossens, J, Cheng, J.D, Baekelandt, V, DeMeester, I, Lambeir, A.M, Augustyns, K. | | Deposit date: | 2012-10-01 | | Release date: | 2013-03-13 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy.
J.Med.Chem., 55, 2012
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