4BCB

PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2- substituted N-acyl-prolylpyrrolidine inhibitor

Summary for 4BCB

• Entry DOI: 10.2210/pdb4bcb/pdb
• Related: 1E5T 1E8M 1E8N 1H2W 1H2X 1H2Y 1H2Z 1O6F 1O6G 1QFM 1QFS 1UOO 1UOP 1UOQ 1VZ2 1VZ3 2XDW 4AMY 4AMZ 4AN0 4AN1 4AX4 4BCC 4BCD
• Related PRD ID: PRD_002042
• Descriptor: PROLYL ENDOPEPTIDASE, (5R,6R,8S)-8-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-5-CYCLOHEXYL-6-HYDROXY-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC ACID 6-OXIDE, TRIS(HYDROXYETHYL)AMINOMETHANE, ... (5 entities in total)
• Functional Keywords: alpha-beta-hydrolase, amnesia, beta-propeller, hydrolase, parkinsons disease, alzheimers disease
• Biological source: SUS SCROFA (PIG)
• Cellular location: Cytoplasm: P23687
• Total number of polymer chains: 1
• Total formula weight: 82255.87

Authors

VanDerVeken, P.,Fulop, V.,Rea, D.,Gerard, M.,VanElzen, R.,Joossens, J.,Cheng, J.D.,Baekelandt, V.,DeMeester, I.,Lambeir, A.M.,Augustyns, K. (deposition date: 2012-10-01, release date: 2013-03-13, Last modification date: 2023-12-20)

• Primary citation: Van Der Veken, P.,Fulop, V.,Rea, D.,Gerard, M.,Van Elzen, R.,Joossens, J.,Cheng, J.D.,Baekelandt, V.,De Meester, I.,Lambeir, A.M.,Augustyns, K.; P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy.; J.Med.Chem., 55:9856-, 2012; PubMed: 23121075; DOI: 10.1021/JM301060G

Experimental method

X-RAY DIFFRACTION (1.7 Å)