4BCC
PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2- substituted N-acyl-prolylpyrrolidine inhibitor
Summary for 4BCC
Entry DOI | 10.2210/pdb4bcc/pdb |
Related | 1E5T 1E8M 1E8N 1H2W 1H2X 1H2Y 1H2Z 1O6F 1O6G 1QFM 1QFS 1UOO 1UOP 1UOQ 1VZ2 1VZ3 2XDW 4AMY 4AMZ 4AN0 4AN1 4AX4 4BCB 4BCD |
Related PRD ID | PRD_002070 |
Descriptor | PROLYL ENDOPEPTIDASE, tert-butyl N-[[1-[(3S,5S)-5-[(2S)-2-[azanyl(oxidanyl)methyl]pyrrolidin-1-yl]carbonyl-1-(4-phenylbutanoyl)pyrrolidin-3-yl]-1,2,3-triazol-4-yl]methyl]carbamate, TRIS(HYDROXYETHYL)AMINOMETHANE, ... (5 entities in total) |
Functional Keywords | alpha-beta-hydrolase, amnesia, hydrolase, parkinsons disease, alzheimers disease, inhibitor |
Biological source | SUS SCROFA (PIG) |
Cellular location | Cytoplasm: P23687 |
Total number of polymer chains | 1 |
Total formula weight | 82412.07 |
Authors | VanDerVeken, P.,Fulop, V.,Rea, D.,Gerard, M.,VanElzen, R.,Joossens, J.,Cheng, J.D.,Baekelandt, V.,DeMeester, I.,Lambeir, A.M.,Augustyns, K. (deposition date: 2012-10-01, release date: 2013-03-13, Last modification date: 2023-12-20) |
Primary citation | Van Der Veken, P.,Fulop, V.,Rea, D.,Gerard, M.,Van Elzen, R.,Joossens, J.,Cheng, J.D.,Baekelandt, V.,De Meester, I.,Lambeir, A.M.,Augustyns, K. P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy. J.Med.Chem., 55:9856-, 2012 Cited by PubMed: 23121075DOI: 10.1021/JM301060G PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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