4BCD

PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor

Summary for 4BCD

Entry DOI	10.2210/pdb4bcd/pdb
Related	1E5T 1E8M 1E8N 1H2W 1H2X 1H2Y 1H2Z 1O6F 1O6G 1QFM 1QFS 1UOO 1UOP 1UOQ 1VZ2 1VZ3 2XDW 4AMY 4AMZ 4AN0 4AN1 4AX4 4BCB 4BCC
Related PRD ID	PRD_002071
Descriptor	PROLYL ENDOPEPTIDASE, 1-[(2S,4S)-4-[4-(4-fluorophenyl)-1,2,3-triazol-1-yl]-2-pyrrolidin-1-ylcarbonyl-pyrrolidin-1-yl]-4-phenyl-butan-1-one, TRIS(HYDROXYETHYL)AMINOMETHANE, ... (5 entities in total)
Functional Keywords	alpha-beta-hydrolase, amnesia, hydrolase, parkinsons disease, alzheimers disease, inhibitor
Biological source	SUS SCROFA (PIG)
Cellular location	Cytoplasm: P23687
Total number of polymer chains	1
Total formula weight	82331.96
Authors	VanDerVeken, P.,Fulop, V.,Rea, D.,Gerard, M.,VanElzen, R.,Joossens, J.,Cheng, J.D.,Baekelandt, V.,DeMeester, I.,Lambeir, A.M.,Augustyns, K. (deposition date: 2012-10-01, release date: 2013-03-13, Last modification date: 2023-12-20)
Primary citation	Van Der Veken, P.,Fulop, V.,Rea, D.,Gerard, M.,Van Elzen, R.,Joossens, J.,Cheng, J.D.,Baekelandt, V.,De Meester, I.,Lambeir, A.M.,Augustyns, K. P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy. J.Med.Chem., 55:9856-, 2012 Cited by PubMed: 23121075 DOI: 10.1021/JM301060G PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation