8P1U
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![BU of 8p1u by Molmil](/molmil-images/mine/8p1u) | Structure of divisome complex FtsWIQLB | 分子名称: | Cell division protein FtsB, Cell division protein FtsL, Cell division protein FtsQ, ... | 著者 | Yang, L, Chang, S, Tang, D, Dong, H. | 登録日 | 2023-05-12 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into the activation of the divisome complex FtsWIQLB. Cell Discov, 10, 2024
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8CBM
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![BU of 8cbm by Molmil](/molmil-images/mine/8cbm) | Structure of human mitochondrial CCA-adding enzyme in complex with mitochondrial pre-tRNA-Ile | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase type-2, CCA tRNA nucleotidyltransferase 1, mitochondrial, ... | 著者 | MEYNIER, V, HARDWICK, S, CATALA, M, ROSKE, J, OERUM, S, CHIRGADZE, D, BARRAUD, P, LUISI, B, TISNE, C. | 登録日 | 2023-01-25 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Structural basis for human mitochondrial tRNA maturation. Nat Commun, 15, 2024
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8CBO
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![BU of 8cbo by Molmil](/molmil-images/mine/8cbo) | Structure of human mitochondrial MRPP1-MRPP2 in complex with mitochondrial pre-tRNA-Ile | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase type-2, Mitochondrial Precursor tRNA-Ile(5,4), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | MEYNIER, V, HARDWICK, S, CATALA, M, ROSKE, J, OERUM, S, CHIRGADZE, D, BARRAUD, P, LUISI, B, TISNE, C. | 登録日 | 2023-01-25 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for human mitochondrial tRNA maturation. Nat Commun, 15, 2024
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8CBK
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![BU of 8cbk by Molmil](/molmil-images/mine/8cbk) | Structure of human mitochondrial RNase P in complex with mitochondrial pre-tRNA-His(5,Ser) | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase type-2, MAGNESIUM ION, Mitochondrial Precursor tRNA-His(5,Ser), ... | 著者 | MEYNIER, V, HARDWICK, S, CATALA, M, ROSKE, J, OERUM, S, CHIRGADZE, D, BARRAUD, P, LUISI, B, TISNE, C. | 登録日 | 2023-01-25 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Structural basis for human mitochondrial tRNA maturation. Nat Commun, 15, 2024
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8CBL
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![BU of 8cbl by Molmil](/molmil-images/mine/8cbl) | Structure of human mitochondrial RNase Z in complex with mitochondrial pre-tRNA-His(0,Ser) | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase type-2, Mitochondrial Precursor tRNA-His(0,Ser), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | MEYNIER, V, HARDWICK, S, CATALA, M, ROSKE, J, OERUM, S, CHIRGADZE, D, BARRAUD, P, YU, W, LUISI, B, TISNE, C. | 登録日 | 2023-01-25 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Structural basis for human mitochondrial tRNA maturation. Nat Commun, 15, 2024
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7POA
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![BU of 7poa by Molmil](/molmil-images/mine/7poa) | An Irreversible, Promiscuous and Highly Thermostable Claisen-Condensation Biocatalyst Drives the Synthesis of Substituted Pyrroles | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Basle, A, Ashley, B, Campopiano, D, Marles-Wright, J. | 登録日 | 2021-09-08 | 公開日 | 2022-09-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Versatile Chemo-Biocatalytic Cascade Driven by a Thermophilic and Irreversible C-C Bond-Forming alpha-Oxoamine Synthase. Acs Sustain Chem Eng, 11, 2023
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7POB
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![BU of 7pob by Molmil](/molmil-images/mine/7pob) | An Irreversible, Promiscuous and Highly Thermostable Claisen-Condensation Biocatalyst Drives the Synthesis of Substituted Pyrroles | 分子名称: | 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION | 著者 | Basle, A, Ashley, B, Campopiano, D, Marles-Wright, J. | 登録日 | 2021-09-08 | 公開日 | 2022-09-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Versatile Chemo-Biocatalytic Cascade Driven by a Thermophilic and Irreversible C-C Bond-Forming alpha-Oxoamine Synthase. Acs Sustain Chem Eng, 11, 2023
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7POC
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![BU of 7poc by Molmil](/molmil-images/mine/7poc) | An Irreversible, Promiscuous and Highly Thermostable Claisen-Condensation Biocatalyst Drives the Synthesis of Substituted Pyrroles | 分子名称: | 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Basle, A, Ashley, B, Campopiano, D, Marles-Wright, J. | 登録日 | 2021-09-08 | 公開日 | 2022-09-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Versatile Chemo-Biocatalytic Cascade Driven by a Thermophilic and Irreversible C-C Bond-Forming alpha-Oxoamine Synthase. Acs Sustain Chem Eng, 11, 2023
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7PQ1
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![BU of 7pq1 by Molmil](/molmil-images/mine/7pq1) | Ligand-free crystal structure of a staphylococcal orthologue of CYP134A1 | 分子名称: | Cytochrome P450 protein, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Snee, M, Levy, C, Leys, D, Katariya, M, Munro, A.W. | 登録日 | 2021-09-15 | 公開日 | 2022-09-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Crystal structure of a staphylococcal orthologue of CYP134A1 (CYPX) in complex with Cyclo-L-leucyl-L-leucine To Be Published
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8PSV
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![BU of 8psv by Molmil](/molmil-images/mine/8psv) | 2.7 A cryo-EM structure of in vitro assembled type 1 pilus rod | 分子名称: | Type-1 fimbrial protein, A chain | 著者 | Hospenthal, M, Zyla, D, Glockshuber, R, Waksman, G. | 登録日 | 2023-07-13 | 公開日 | 2024-04-10 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili. Nat Commun, 15, 2024
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8DKR
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![BU of 8dkr by Molmil](/molmil-images/mine/8dkr) | |
8POA
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![BU of 8poa by Molmil](/molmil-images/mine/8poa) | Structure of Coxsackievirus A16 (G-10) 2A protease | 分子名称: | GLYCEROL, Protease 2A, ZINC ION | 著者 | Lithgo, R.M, Fairhead, M, Koekemoer, L, Aschenbrenner, J.C, Balcomb, B.H, Godoy, A.S, Marples, P.G, Ni, X, Tomlinson, C.W.E, Thompson, W, Wild, C, Fearon, D, Walsh, M.A, von Delft, F. | 登録日 | 2023-07-04 | 公開日 | 2023-08-02 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of EV A71 2A protease - to be published To Be Published
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7B0N
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7W2Z
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![BU of 7w2z by Molmil](/molmil-images/mine/7w2z) | Cryo-EM structure of the ghrelin-bound human ghrelin receptor-Go complex | 分子名称: | Appetite-regulating hormone, CHOLESTEROL, Growth hormone secretagogue receptor type 1, ... | 著者 | Qin, J, Ming, Q, Ji, S, Mao, C, Shen, D, Zhang, Y. | 登録日 | 2021-11-24 | 公開日 | 2022-01-19 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular mechanism of agonism and inverse agonism in ghrelin receptor. Nat Commun, 13, 2022
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7AWA
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![BU of 7awa by Molmil](/molmil-images/mine/7awa) | SctV (SsaV) cytoplasmic domain | 分子名称: | Secretion system apparatus protein SsaV | 著者 | Matthews-Palmer, T.R.S, Gonzalez-Rodriguez, N, Calcraft, T, Lagercrantz, S, Zachs, T, Yu, X.J, Grabe, G, Holden, D, Nans, A, Rosenthal, P, Rouse, S, Beeby, M. | 登録日 | 2020-11-06 | 公開日 | 2021-04-14 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the cytoplasmic domain of SctV (SsaV) from the Salmonella SPI-2 injectisome and implications for a pH sensing mechanism. J.Struct.Biol., 213, 2021
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8PX1
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![BU of 8px1 by Molmil](/molmil-images/mine/8px1) | Structure of salmonella effector SseK3, solved at wavelength 2.75 A | 分子名称: | Non-LEE encoded effector protein NleB | 著者 | El Omari, K, Duman, R, Mykhaylyk, V, Orr, C.M, Esposito, D, Rittinger, K, Wagner, A. | 登録日 | 2023-07-22 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Experimental phasing opportunities for macromolecular crystallography at very long wavelengths. Commun Chem, 6, 2023
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8D0A
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![BU of 8d0a by Molmil](/molmil-images/mine/8d0a) | Crystal structure of human USP30 in complex with a covalent inhibitor 829 and a Fab | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION, mouse anti-huUSP30 Fab heavy chain, ... | 著者 | Song, X, Butler, J, Li, C, Zhang, K, Zhang, D, Hao, Y. | 登録日 | 2022-05-25 | 公開日 | 2023-02-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | TBD To Be Published
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8D1W
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![BU of 8d1w by Molmil](/molmil-images/mine/8d1w) | Crystal structure of Plasmodium falciparum GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | 分子名称: | 8-{[(2-chlorophenyl)methyl]amino}adenosine, Chaperone DnaK, SULFATE ION | 著者 | Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W, Smil, D, Zepeda, C.A.V. | 登録日 | 2022-05-27 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Targeting Plasmodium falciparum GRP78: nucleoside analogues as agents against the malaria chaperone Frontiers in Molecular Bioscience, 2022
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6AR4
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7AMH
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![BU of 7amh by Molmil](/molmil-images/mine/7amh) | SmBRD3(2), Second Bromodomain of Bromodomain 3 from Schistosoma mansoni in complex with DM-A-33, an iBET726 analogue | 分子名称: | 4-{(2S, 4R)-1-acetyl-4-[(1-benzothiophen-6-yl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl}benzoic acid, Putative bromodomain-containing protein 3, ... | 著者 | McArdle, D, Schiedel, M, McDonough, M.A, Conway, S.J. | 登録日 | 2020-10-08 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.863 Å) | 主引用文献 | SBM3_2, Second Bromodomain of Bromodomain 3 from Schistosoma mansoni in complex with DM1, an iBET726 analogue To Be Published
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7WBN
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![BU of 7wbn by Molmil](/molmil-images/mine/7wbn) | PDB structure of RevCC | 分子名称: | RevCC | 著者 | Han, S, Kim, D, Kaur, M, Lim, Y.B, Barnwal, R.P. | 登録日 | 2021-12-17 | 公開日 | 2022-10-26 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Pseudo-Isolated alpha-Helix Platform for the Recognition of Deep and Narrow Targets. J.Am.Chem.Soc., 144, 2022
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8PTU
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![BU of 8ptu by Molmil](/molmil-images/mine/8ptu) | 2.5 A cryo-EM structure of the in vitro FimD-catalyzed assembly of type 1 pilus rod | 分子名称: | Type-1 fimbrial protein, A chain | 著者 | Zyla, D, Hospenthal, M, Glockshuber, R, Waksman, G. | 登録日 | 2023-07-14 | 公開日 | 2024-04-10 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | 主引用文献 | The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili. Nat Commun, 15, 2024
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6B7E
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![BU of 6b7e by Molmil](/molmil-images/mine/6b7e) | Crystal structure of E.coli Phosphopantetheine Adenylyltransferase (PPAT/CoaD) in complex with (R)-4-(5-(difluoromethyl)-1H-imidazol-1-yl)-3,3-dimethylisochroman-1-one | 分子名称: | (4R)-4-[5-(difluoromethyl)-1H-imidazol-1-yl]-3,3-dimethyl-3,4-dihydro-1H-2-benzopyran-1-one, DIMETHYL SULFOXIDE, Phosphopantetheine adenylyltransferase, ... | 著者 | Proudfoot, A.W, Bussiere, D, Lingel, A. | 登録日 | 2017-10-03 | 公開日 | 2017-12-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.104 Å) | 主引用文献 | High-Confidence Protein-Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization. J. Am. Chem. Soc., 139, 2017
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7QH1
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![BU of 7qh1 by Molmil](/molmil-images/mine/7qh1) | Discovery and development of a novel inhaled antivirulence therapy for the treatment of Pseudomonas aeruginosa infections in patients with chronic respiratory disease | 分子名称: | 2-[2-[[5-[3-[bis(2-hydroxyethyl)-methyl-$l^{4}-azanyl]propoxy]-6-methoxy-1,3-benzothiazol-2-yl]methylcarbamoyl]-5,6-bis(fluoranyl)-1,3-dihydroinden-2-yl]ethanoic acid, CALCIUM ION, Keratinase KP2, ... | 著者 | Leonard, P.M, Davies, D, Pallin, T.D. | 登録日 | 2021-12-10 | 公開日 | 2022-12-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1 beta in Cellular and Animal Infection Models. Acs Infect Dis., 9, 2023
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6B7F
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![BU of 6b7f by Molmil](/molmil-images/mine/6b7f) | Crystal structure of E.coli Phosphopantetheine Adenylyltransferase (PPAT/CoaD) in complex with (R)-3,3-dimethyl-4-(5-vinyl-1H-imidazol-1-yl)isochroman-1-one | 分子名称: | (4R)-4-(5-ethenyl-1H-imidazol-1-yl)-3,3-dimethyl-3,4-dihydro-1H-2-benzopyran-1-one, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYL SULFOXIDE, ... | 著者 | Proudfoot, A.W, Bussiere, D, Lingel, A. | 登録日 | 2017-10-03 | 公開日 | 2017-12-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.562 Å) | 主引用文献 | High-Confidence Protein-Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization. J. Am. Chem. Soc., 139, 2017
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