7POA

An Irreversible, Promiscuous and Highly Thermostable Claisen-Condensation Biocatalyst Drives the Synthesis of Substituted Pyrroles

Summary for 7POA

Entry DOI	10.2210/pdb7poa/pdb
Descriptor	8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase, PYRIDOXAL-5'-PHOSPHATE, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
Functional Keywords	biocatalyst, cascade, chemo-enzymatic, thermophilic, promiscuous, alpha-oxoamine synthase, pyrrole, synthase
Biological source	Thermus thermophilus
Total number of polymer chains	2
Total formula weight	93996.98
Authors	Basle, A.,Ashley, B.,Campopiano, D.,Marles-Wright, J. (deposition date: 2021-09-08, release date: 2022-09-21, Last modification date: 2024-02-28)
Primary citation	Ashley, B.,Basle, A.,Sajjad, M.,El Ashram, A.,Kelis, P.,Marles-Wright, J.,Campopiano, D.J. Versatile Chemo-Biocatalytic Cascade Driven by a Thermophilic and Irreversible C-C Bond-Forming alpha-Oxoamine Synthase. Acs Sustain Chem Eng, 11:7997-8002, 2023 Cited by PubMed: 37266354 DOI: 10.1021/acssuschemeng.3c00243 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation