6WNX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wnx by Molmil](/molmil-images/mine/6wnx) | FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide | 分子名称: | Catenin beta-1, F-box/WD repeat-containing protein 11, GLYCEROL, ... | 著者 | Ivanochko, D, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Boettcher, J, Structural Genomics Consortium (SGC) | 登録日 | 2020-04-23 | 公開日 | 2020-05-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide To Be Published
|
|
8VSA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8vsa by Molmil](/molmil-images/mine/8vsa) | Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site of E. coli 70S ribosome | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Teran, D, Zhang, Y, Korostelev, A.A. | 登録日 | 2024-01-23 | 公開日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Endogenous trans-translation structure visualizes the decoding of the first tmRNA alanine codon. Front Microbiol, 15, 2024
|
|
1RYX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ryx by Molmil](/molmil-images/mine/1ryx) | |
5J8I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5j8i by Molmil](/molmil-images/mine/5j8i) | Crystal structure of TL11-113 bound to TAK1-TAB1 | 分子名称: | Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera, N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | 著者 | Gurbani, D, Westover, K.D. | 登録日 | 2016-04-07 | 公開日 | 2017-02-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.404 Å) | 主引用文献 | Structure-guided development of covalent TAK1 inhibitors. Bioorg. Med. Chem., 25, 2017
|
|
6WP6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wp6 by Molmil](/molmil-images/mine/6wp6) | Pyruvate Kinase M2 mutant-S37E K433E | 分子名称: | GLYCEROL, MAGNESIUM ION, NITRATE ION, ... | 著者 | Nandi, S, Razzaghi, M, Srivastava, D, Dey, M. | 登録日 | 2020-04-26 | 公開日 | 2020-10-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation. J.Biol.Chem., 295, 2020
|
|
8VS9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8vs9 by Molmil](/molmil-images/mine/8vs9) | Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site and deacyl-tRNA in the E site of E. coli 70S ribosome | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Teran, D, Zhang, Y, Korostelev, A.A. | 登録日 | 2024-01-23 | 公開日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Endogenous trans-translation structure visualizes the decoding of the first tmRNA alanine codon. Front Microbiol, 15, 2024
|
|
6WVT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wvt by Molmil](/molmil-images/mine/6wvt) | Structural basis of alphaE-catenin - F-actin catch bond behavior | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Xu, X.P, Pokutta, S, Torres, M, Swift, M.F, Hanein, D, Volkmann, N, Weis, W.I. | 登録日 | 2020-05-06 | 公開日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | 主引用文献 | Structural basis of alpha E-catenin-F-actin catch bond behavior. Elife, 9, 2020
|
|
8V9M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v9m by Molmil](/molmil-images/mine/8v9m) | Human Ornithine Aminotransferase cocrystallized with its inhibitor, (R)-3-amino-5,5-difluorocyclohex-1-ene-1-carboxylic acid. | 分子名称: | 3-fluoro-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]benzoic acid, GLYCEROL, Ornithine aminotransferase, ... | 著者 | Vargas, A.L, Devitt, A, Kaley, N, Silverman, R, Liu, D. | 登録日 | 2023-12-08 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. Acs Chem.Biol., 19, 2024
|
|
5J9L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5j9l by Molmil](/molmil-images/mine/5j9l) | Crystal structure of CPT1691 bound to TAK1-TAB1 | 分子名称: | Mitogen-activated protein kinase kinase kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, N-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide | 著者 | Gurbani, D, Westover, K.D. | 登録日 | 2016-04-10 | 公開日 | 2017-02-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7515 Å) | 主引用文献 | Structure-guided development of covalent TAK1 inhibitors. Bioorg. Med. Chem., 25, 2017
|
|
5J9Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5j9z by Molmil](/molmil-images/mine/5j9z) | EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1a | 分子名称: | (R)-1-(3-(4-amino-3-(1-methyl-1H-indol-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, Epidermal growth factor receptor | 著者 | Becker, C, Engel, J, Rauh, D. | 登録日 | 2016-04-11 | 公開日 | 2016-08-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR. Angew.Chem.Int.Ed.Engl., 55, 2016
|
|
8WO0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wo0 by Molmil](/molmil-images/mine/8wo0) | CryoEM structure of ZIKV rsNS1 filament | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Non-structural protein 1 | 著者 | Chew, B.L.A, Luo, D. | 登録日 | 2023-10-06 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (8 Å) | 主引用文献 | Structural basis of Zika virus NS1 multimerization and human antibody recognition Npj Viruses, 2, 2024
|
|
8WN8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wn8 by Molmil](/molmil-images/mine/8wn8) | CryoEM structure of ZIKV rsNS1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Non-structural protein 1 | 著者 | Chew, B.L.A, Luo, D. | 登録日 | 2023-10-05 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of Zika virus NS1 multimerization and human antibody recognition Npj Viruses, 2, 2024
|
|
8WO4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wo4 by Molmil](/molmil-images/mine/8wo4) | |
6XKV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xkv by Molmil](/molmil-images/mine/6xkv) | R. capsulatus cyt bc1 with both FeS proteins in b position (CIII2 b-b) | 分子名称: | Cytochrome b, Cytochrome c1, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F. | 登録日 | 2020-06-27 | 公開日 | 2020-12-30 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes. Nat Commun, 12, 2021
|
|
8WNP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wnp by Molmil](/molmil-images/mine/8wnp) | |
1S5J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1s5j by Molmil](/molmil-images/mine/1s5j) | Insight in DNA Replication: The crystal structure of DNA Polymerase B1 from the archaeon Sulfolobus solfataricus | 分子名称: | DNA polymerase I, MAGNESIUM ION, SULFATE ION | 著者 | Savino, C, Federici, L, Nastopoulos, V, Johnson, K.A, Pisani, F.M, Rossi, M, Tsernoglou, D. | 登録日 | 2004-01-21 | 公開日 | 2004-11-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Insights into DNA replication: the crystal structure of DNA polymerase B1 from the archaeon Sulfolobus solfataricus Structure, 12, 2004
|
|
8WNU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wnu by Molmil](/molmil-images/mine/8wnu) | |
5JMF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jmf by Molmil](/molmil-images/mine/5jmf) | Heparinase III-BT4657 gene product | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Heparinase III protein, ... | 著者 | Ulaganathan, T.S, Shi, R, Yao, D, Garron, M.-L, Cherney, M, Cygler, M. | 登録日 | 2016-04-28 | 公開日 | 2016-05-25 | 最終更新日 | 2018-01-17 | 実験手法 | X-RAY DIFFRACTION (1.854 Å) | 主引用文献 | Conformational flexibility of PL12 family heparinases: structure and substrate specificity of heparinase III from Bacteroides thetaiotaomicron (BT4657). Glycobiology, 27, 2017
|
|
5IUB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5iub by Molmil](/molmil-images/mine/5iub) | Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12x at 2.1A resolution | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, ... | 著者 | Segala, E, Guo, D, Cheng, R.K.Y, Bortolato, A, Deflorian, F, Dore, A.S, Errey, J.C, Heitman, L.H, Ijzerman, A.P, Marshall, F.H, Cooke, R.M. | 登録日 | 2016-03-17 | 公開日 | 2016-06-29 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength. J.Med.Chem., 59, 2016
|
|
6YLA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yla by Molmil](/molmil-images/mine/6yla) | Crystal structure of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | 著者 | Huo, J, Zhao, Y, Ren, J, Zhou, D, Ginn, H.M, Fry, E.E, Owens, R, Stuart, D.I. | 登録日 | 2020-04-06 | 公開日 | 2020-04-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike. Cell Host Microbe, 28, 2020
|
|
6YQ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yq1 by Molmil](/molmil-images/mine/6yq1) | FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(3-{[2-(2-oxo-1,2,3,4-tetrahydro-quinolin-6-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide | 分子名称: | Focal adhesion kinase 1, SODIUM ION, SULFATE ION, ... | 著者 | Musil, D, Heinrich, T, Amaral, M. | 登録日 | 2020-04-16 | 公開日 | 2021-02-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.784 Å) | 主引用文献 | Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Cell Chem Biol, 28, 2021
|
|
6YR9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yr9 by Molmil](/molmil-images/mine/6yr9) | |
1D5A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1d5a by Molmil](/molmil-images/mine/1d5a) | CRYSTAL STRUCTURE OF AN ARCHAEBACTERIAL DNA POLYMERASE D.TOK. DEPOSITION OF SECOND NATIVE STRUCTURE AT 2.4 ANGSTROM | 分子名称: | MAGNESIUM ION, PROTEIN (DNA POLYMERASE), SULFATE ION | 著者 | Zhao, Y, Jeruzalmi, D, Leighton, L, Lasken, R, Kuriyan, J. | 登録日 | 1999-10-06 | 公開日 | 2000-03-24 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of an archaebacterial DNA polymerase. Structure Fold.Des., 7, 1999
|
|
6YOJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yoj by Molmil](/molmil-images/mine/6yoj) | |
6YK8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yk8 by Molmil](/molmil-images/mine/6yk8) | |