6YR9

FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide

Summary for 6YR9

• Entry DOI: 10.2210/pdb6yr9/pdb
• Descriptor: Focal adhesion kinase 1, N-Methyl-N-(2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide (3 entities in total)
• Functional Keywords: protein tyrosine kinase, atp binding, transferase, transferase-inhibitor complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 131234.82

Authors

Musil, D.,Amaral, M. (deposition date: 2020-04-19, release date: 2021-02-10, Last modification date: 2024-01-24)

• Primary citation: Berger, B.T.,Amaral, M.,Kokh, D.B.,Nunes-Alves, A.,Musil, D.,Heinrich, T.,Schroder, M.,Neil, R.,Wang, J.,Navratilova, I.,Bomke, J.,Elkins, J.M.,Muller, S.,Frech, M.,Wade, R.C.,Knapp, S.; Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.; Cell Chem Biol, 28:686-, 2021; PubMed: 33497606; DOI: 10.1016/j.chembiol.2021.01.003

Experimental method

X-RAY DIFFRACTION (1.925 Å)