6YOJ

FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one

Summary for 6YOJ

Entry DOI	10.2210/pdb6yoj/pdb
Descriptor	Focal adhesion kinase 1, 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1~{H}-quinolin-2-one (3 entities in total)
Functional Keywords	protein tyrosine kinase, atp binding, transferase, transferase-inhibitor complex
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32795.71
Authors	Musil, D.,Heinrich, T. (deposition date: 2020-04-14, release date: 2021-02-10, Last modification date: 2024-01-24)
Primary citation	Berger, B.T.,Amaral, M.,Kokh, D.B.,Nunes-Alves, A.,Musil, D.,Heinrich, T.,Schroder, M.,Neil, R.,Wang, J.,Navratilova, I.,Bomke, J.,Elkins, J.M.,Muller, S.,Frech, M.,Wade, R.C.,Knapp, S. Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Cell Chem Biol, 28:686-, 2021 Cited by PubMed: 33497606 DOI: 10.1016/j.chembiol.2021.01.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.361 Å)

Structure validation