6YOJ
FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Focal adhesion kinase 1 | polymer | 282 | 32304.2 | 1 | UniProt (Q05397) Pfam (PF07714) In PDB | Homo sapiens (Human) | FADK 1,Focal adhesion kinase-related nonkinase,FRNK,Protein phosphatase 1 regulatory subunit 71,PPP1R71,Protein-tyrosine kinase 2,p125FAK,pp125FAK |
| 2 | A | 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1~{H}-quinolin-2-one | non-polymer | 491.5 | 1 | Chemie (P4N) | |||
| 3 | water | water | 18.0 | 364 | Chemie (HOH) |
Sequence modifications
A: 411 - 689 (UniProt: Q05397)
| PDB | External Database | Details |
|---|---|---|
| Gly 408 | - | expression tag |
| Ser 409 | - | expression tag |
| Gly 410 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32304.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 491.5 | |
| All* | Total formula weight | 32795.7 |
