8CGI
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![BU of 8cgi by Molmil](/molmil-images/mine/8cgi) | Pentacycline TP038 bound to the 30S head | Descriptor: | 16S rRNA, 30S ribosomal protein S7, Large ribosomal subunit protein bL31A, ... | Authors: | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | Deposit date: | 2023-02-04 | Release date: | 2023-07-26 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (1.89 Å) | Cite: | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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5JQT
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![BU of 5jqt by Molmil](/molmil-images/mine/5jqt) | Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH 7.4 | Descriptor: | 1,1-dihydroxy-1,3-dihydro-2,1-benzoxaborol-1-ium, 2,1-benzoxaborol-1(3H)-ol, 4-(HYDROXYMERCURY)BENZOIC ACID, ... | Authors: | Alterio, V, Esposito, D, Di Fiore, A, De Simone, G. | Deposit date: | 2016-05-05 | Release date: | 2016-10-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Benzoxaborole as a new chemotype for carbonic anhydrase inhibition. Chem.Commun.(Camb.), 52, 2016
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6EYN
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![BU of 6eyn by Molmil](/molmil-images/mine/6eyn) | Structure of the 8D6 (anti-IgE) Fab | Descriptor: | 1,2-ETHANEDIOL, 8D6 Fab heavy chain, 8D6 Fab light chain, ... | Authors: | Chen, J.B, Ramadani, F, Pang, M.O.Y, Beavil, R.L, Holdom, M.D, Mitropoulou, A.N, Beavil, A.J, Gould, H.J, Chang, T.W, Sutton, B.J, McDonnell, J.M, Davies, A.M. | Deposit date: | 2017-11-13 | Release date: | 2018-08-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody. Sci Rep, 8, 2018
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5UF4
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![BU of 5uf4 by Molmil](/molmil-images/mine/5uf4) | Crystal Structure of Variable Lymphocyte Receptor (VLR) O13 with LNnT bound | Descriptor: | O13, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Gunn, R.J, Collins, B.C, McKitrick, T.R, Cummings, R.D, Cooper, M.D, Herrin, B.R, Wilson, I.A. | Deposit date: | 2017-01-03 | Release date: | 2017-10-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structural Insights into VLR Fine Specificity for Blood Group Carbohydrates. Structure, 25, 2017
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8CF1
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![BU of 8cf1 by Molmil](/molmil-images/mine/8cf1) | Tetracycline bound to the 30S head | Descriptor: | 16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S7, ... | Authors: | Paternoga, H, Crowe-McAuliffe, C, Beckert, B, Wilson, D.N. | Deposit date: | 2023-02-02 | Release date: | 2023-07-26 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (1.82 Å) | Cite: | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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6FEA
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![BU of 6fea by Molmil](/molmil-images/mine/6fea) | A. vinelandii vanadium nitrogenase, turnover state | Descriptor: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, CARBONATE ION, FE(8)-S(7) CLUSTER, ... | Authors: | Sippel, D, Einsle, O. | Deposit date: | 2017-12-31 | Release date: | 2018-03-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | A bound reaction intermediate sheds light on the mechanism of nitrogenase. Science, 359, 2018
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6S53
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![BU of 6s53 by Molmil](/molmil-images/mine/6s53) | Crystal structure of TRIM21 RING domain in complex with an isopeptide-linked Ube2N~ubiquitin conjugate | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, ... | Authors: | Kiss, L, Boland, A, Neuhaus, D, James, L.C. | Deposit date: | 2019-06-30 | Release date: | 2019-09-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases. Nat Commun, 10, 2019
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8SQ8
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![BU of 8sq8 by Molmil](/molmil-images/mine/8sq8) | X-ray crystal structure of Acinetobacter baumanii beta-lactamase variant OXA-109 in complex with doripenem | Descriptor: | (4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase OXA-109 | Authors: | Powers, R.A, Leonard, D.A, June, C.M, Szarecka, A, Wawrzak, Z. | Deposit date: | 2023-05-04 | Release date: | 2024-05-22 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structural and Dynamic Features of Acinetobacter baumannii OXA-66 beta-Lactamase Explain Its Stability and Evolution of Novel Variants. J.Mol.Biol., 436, 2024
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8HB3
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![BU of 8hb3 by Molmil](/molmil-images/mine/8hb3) | Crystal structure of NAD-II riboswitch (two strands) with NR | Descriptor: | Nicotinamide riboside, RNA (31-MER), RNA (5'-R(*AP*GP*AP*GP*CP*GP*UP*UP*GP*CP*GP*UP*CP*CP*GP*AP*AP*AP*GP*UP*(CBV)P*GP*CP*C)-3') | Authors: | Peng, X, Lilley, D.M.J, Huang, L. | Deposit date: | 2022-10-27 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Crystal structures of the NAD+-II riboswitch reveal two distinct ligand-binding pockets. Nucleic Acids Res., 51, 2023
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7KTX
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![BU of 7ktx by Molmil](/molmil-images/mine/7ktx) | Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to a Fab in DDM detergent | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ER membrane protein complex subunit 2, ... | Authors: | Miller-Vedam, L.E, Schirle Oakdale, N.S, Braeuning, B, Boydston, E.A, Sevillano, N, Popova, K.D, Bonnar, J.L, Shurtleff, M.J, Prabu, J.R, Stroud, R.M, Craik, C.S, Schulman, B.A, Weissman, J.S, Frost, A. | Deposit date: | 2020-11-24 | Release date: | 2020-12-02 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife, 9, 2020
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8T14
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![BU of 8t14 by Molmil](/molmil-images/mine/8t14) | ADP-bound Bcs1 (C7 symmetrized) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Mitochondrial chaperone BCS1 | Authors: | Zhan, J, Xia, D. | Deposit date: | 2023-06-01 | Release date: | 2024-06-05 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate. Nat Commun, 15, 2024
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7W3T
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![BU of 7w3t by Molmil](/molmil-images/mine/7w3t) | Cryo-EM structure of plant receptor like kinase NbBAK1 in RXEG1-BAK1-XEG1 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Brassinosteroid insensitive 1-associated receptor kinase 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Sun, Y, Wang, Y, Zhang, X.X, Chen, Z.D, Xia, Y.Q, Sun, Y.J, Zhang, M.M, Xiao, Y, Han, Z.F, Wang, Y.C, Chai, J.J. | Deposit date: | 2021-11-26 | Release date: | 2022-06-22 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Plant receptor-like protein activation by a microbial glycoside hydrolase. Nature, 610, 2022
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6UWD
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![BU of 6uwd by Molmil](/molmil-images/mine/6uwd) | Crystal structure of Apo AtmM | Descriptor: | ACETATE ION, D-glucose O-methyltransferase, MAGNESIUM ION | Authors: | Alvarado, S.K, Wang, Z, Miller, M.D, Thorson, J.S, Phillips Jr, G.N. | Deposit date: | 2019-11-05 | Release date: | 2020-11-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structure of Apo AtmM To Be Published
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7KMG
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![BU of 7kmg by Molmil](/molmil-images/mine/7kmg) | LY-CoV555 neutralizing antibody against SARS-CoV-2 | Descriptor: | GLYCEROL, LY-CoV555 Fab heavy chain, LY-CoV555 Fab light chain, ... | Authors: | Hendle, J, Pustilnik, A, Sauder, J.M, Coleman, K.A, Boyles, J.S, Dickinson, C.D. | Deposit date: | 2020-11-02 | Release date: | 2021-01-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates. Sci Transl Med, 13, 2021
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8CAM
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![BU of 8cam by Molmil](/molmil-images/mine/8cam) | Evernimicin bound to the 50S subunit | Descriptor: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | Authors: | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | Deposit date: | 2023-01-24 | Release date: | 2023-07-26 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (1.86 Å) | Cite: | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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8T5U
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![BU of 8t5u by Molmil](/molmil-images/mine/8t5u) | ATP-1 state of Bcs1 (C7 symmetrized) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mitochondrial chaperone BCS1 | Authors: | Zhan, J, Xia, D. | Deposit date: | 2023-06-14 | Release date: | 2024-06-05 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate. Nat Commun, 15, 2024
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5CDN
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![BU of 5cdn by Molmil](/molmil-images/mine/5cdn) | 2.8A structure of etoposide with S.aureus DNA gyrase and DNA | Descriptor: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*GP*AP*GP*CP*GP*TP*AP**GP*GP*CP*CP*GP*TP*AP*CP*GP*CP*TP*C)-3'), DNA (5'-D(P*GP*AP*GP*CP*GP*TP*AP*C*GP*GP*CP*CP*GP*TP*AP*CP*GP*CP*TP*C)-3'), ... | Authors: | Bax, B.D, Srikannathasan, V, Chan, P.F. | Deposit date: | 2015-07-04 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin. Nat Commun, 6, 2015
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5FRM
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![BU of 5frm by Molmil](/molmil-images/mine/5frm) | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ384 (compound 4a) | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-azanylidene-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', ... | Authors: | Maskell, D.P, Pye, V.E, Cherepanov, P. | Deposit date: | 2015-12-18 | Release date: | 2016-02-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. Acs Chem.Biol., 11, 2016
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5MJJ
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![BU of 5mjj by Molmil](/molmil-images/mine/5mjj) | |
5MKG
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![BU of 5mkg by Molmil](/molmil-images/mine/5mkg) | PA3825-EAL Ca-CdG Structure | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, Diguanylate phosphodiesterase | Authors: | Horrell, S, Bellini, D, Strange, R, Wagner, A, Walsh, M. | Deposit date: | 2016-12-04 | Release date: | 2016-12-14 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases. Sci Rep, 7, 2017
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8CA7
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![BU of 8ca7 by Molmil](/molmil-images/mine/8ca7) | Omadacycline and spectinomycin bound to the 30S ribosomal subunit head | Descriptor: | 16S rRNA, 30S ribosomal protein S7, MAGNESIUM ION, ... | Authors: | Paternoga, H, Crowe-McAuliffe, C, Wilson, D.N. | Deposit date: | 2023-01-24 | Release date: | 2023-08-02 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.06 Å) | Cite: | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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7KVB
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![BU of 7kvb by Molmil](/molmil-images/mine/7kvb) | Chimeric flavivirus between Binjari virus and Murray Valley encephalitis virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein E, Matrix protein M | Authors: | Hardy, J.M, Venugopal, H.V, Newton, N.D, Watterson, D, Coulibaly, F.J. | Deposit date: | 2020-11-27 | Release date: | 2020-12-23 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses. Nat Commun, 12, 2021
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6Y0N
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![BU of 6y0n by Molmil](/molmil-images/mine/6y0n) | Arginine hydroxylase VioC in complex with Arg, 2OG and Fe under anaerobic environment using FT-SSX methods | Descriptor: | 2-OXOGLUTARIC ACID, ARGININE, Alpha-ketoglutarate-dependent L-arginine hydroxylase, ... | Authors: | Rabe, P, Beale, J.H, Lang, P.A, Dirr, S.A, Leissing, T.M, Butryn, A, Aller, P, Kamps, J.J.A.G, Axford, D, McDonough, M.A, Orville, A.M, Owen, R, Schofield, C.J. | Deposit date: | 2020-02-10 | Release date: | 2020-09-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Anaerobic fixed-target serial crystallography. Iucrj, 7, 2020
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6N6K
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![BU of 6n6k by Molmil](/molmil-images/mine/6n6k) | Human REXO2 bound to pAG | Descriptor: | MALONATE ION, RNA (5'-R(P*AP*G)-3'), RNA exonuclease 2 homolog,Small fragment nuclease, ... | Authors: | Lormand, J.D, Sondermann, H. | Deposit date: | 2018-11-26 | Release date: | 2019-06-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.418 Å) | Cite: | A dedicated diribonucleotidase resolves a key bottleneck for the terminal step of RNA degradation. Elife, 8, 2019
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5CG0
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![BU of 5cg0 by Molmil](/molmil-images/mine/5cg0) | Crystal structure of Spodoptera frugiperda Beta-glycosidase | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Tamaki, F.K, Souza, D.P, Souza, V.P, Farah, S.C, Marana, S.R. | Deposit date: | 2015-07-08 | Release date: | 2015-12-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Using the Amino Acid Network to Modulate the Hydrolytic Activity of beta-Glycosidases. PLoS ONE, 11, 2016
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